Rationale: cluster all secreted proteins based on their structures

1. Clip pdb files to remove signal peptides

secreted<-read.delim2( "../analysis_and_temp_files/01_predicting_effectors/all_secreted_list.txt", sep = "\t",header = F)

signal<-read.delim2("../analysis_and_temp_files/01_predicting_effectors/GTX0501_signalp_prediction_results.txt",skip=1) %>% filter(Prediction!="OTHER") %>%
  mutate(TranscriptID = X..ID,
         last_position_in_SP = as.numeric(gsub("CS pos: ([0-9]+)-.*$", "\\1", CS.Position))) %>%
  select(TranscriptID,last_position_in_SP,CS.Position) %>%
  filter(TranscriptID %in% secreted$V1)
library(Rpdb)
## Loading required package: rgl
## This build of rgl does not include OpenGL functions.  Use
##  rglwidget() to display results, e.g. via options(rgl.printRglwidget = TRUE).
## 
## Attaching package: 'Rpdb'
## The following objects are masked from 'package:base':
## 
##     norm, replicate, unsplit
clip_SP <- function(input_file,output_file,residue){
pdb<-read.pdb(input_file)
pdb_subset<-subset(pdb,pdb$atoms$resid>residue)
write.pdb(pdb_subset,output_file)
rm(pdb,pdb_subset)}
df<-data.frame("input_file" = list.files("../analysis_and_temp_files/03_fold_secretome/colab_fold_best_model", pattern=".pdb",full.names = T)) %>%
  mutate(TranscriptID = gsub("../analysis_and_temp_files/03_fold_secretome/colab_fold_best_model/(.*)_unrelaxed.*$", "\\1", input_file)) %>%
         mutate(output_file = paste0("../analysis_and_temp_files/05_cluster_structures/pdb_signal_removed/",TranscriptID,"_clipped.pdb")) %>% left_join(signal)
mapply(clip_SP, df$input_file,df$output_file,df$last_position_in_SP)

2. SP removal -> Foldtree:

Compare the three trees

  • Foldtree produces three trees:

    • foldtree: based on the global structure alignment
    • lddt: based on the local structure alignment
    • alntm: based on the sequence alignment

  • The trees seem very different

  • Anecdotally comparing the trees. Took one protein model: FUN_009178-T1

    • In alntm tree it’s sister to FUN_009311-T1, but it doesn’t align at all in ChimeraX
    • In foldtree it’s sister to FUN_003873-T1, in ChimeraX it’s more similar but still doesn’t align well
    • In lddt it’s sister to FUN_010665-T1, and it matches great in Chimera X

  • Took another example: FUN_005200-T1

    • In alntm it’s sister to FUN_005151-T1, and it matches great in Chimera X
    • In foldtree it’s sister to FUN_000470-T1
    • In lddt it’s sister to FUN_005151-T1, and it matches great in Chimera X

  • In these examples, lddt works best

  • Results: the tree seems random. The proteins with identical or nearly identical sequences are grouped together, as expected. But beyond that, clades make no sense

3. SP removal -> Filtering -> Foldtree

Comparing the trees

  • Comparing the trees to each other and also to the previous run with the infiltered set of trees

  • The same anecdotal example: FUN_009178-T1

    • In foldtree it’s sister to FUN_004818-T1, doesn’t align in ChimeraX. Different from the full tree
    • In alntm tree it’s sister to FUN_8015-T1, aligns well in ChimeraX. Different from the full tree
    • In lddt it’s sister to (FUN_010665-T1 and FUN_8015-T1), and it matches great in Chimera X. Partially same as in the full tree

  • The same anecdotal example: FUN_005200-T1

    • In foldtree it’s sister to FUN_002283-T1, doesn’t align in ChimeraX. Different from the full tree
    • In alntm tree it’s sister to FUN_002910-T1, aligns well in ChimeraX. Different from the full tree
    • In dllt tree it’s sister to FUN_005151-T1, aligns well in ChimeraX. Same as in the full tree

  • Foldtree tree (pTM = global alignment) consistantly fails. Will use lDDT tree instead

  • On the large scale, all three trees are completely incongruent

library(ape)
library(treeio)
lddt<-treeio::read.newick("../analysis_and_temp_files/05_cluster_structures/pdb_SP_removed_filtered_da39a/lddt_struct_tree.nwk")
fold<-treeio::read.newick("../analysis_and_temp_files/05_cluster_structures/pdb_SP_removed_filtered_da39a/foldtree_struct_tree.nwk")
aln<-treeio::read.newick("../analysis_and_temp_files/05_cluster_structures/pdb_SP_removed_filtered_da39a/alntmscore_struct_tree.nwk")

assoc<-data.frame(fold$tip.label ,fold$tip.label)
cophyloplot(lddt,aln,assoc,space=400)

  • Went through the lDDT tree and annotated all potential clusters.
    • Annotation as an svg file is in analysis_and_temp_files/05_cluster_structures/pdb_SP_removed_filtered_da39a/lddt_struct_tree_annotated.svg
    • Tree mostly makes sense and many reasonable clusters can be derived from it
    • The lower part of the tree is very messy. I suspect the reason is that most of proteins there have long disordered regions that mess with the clustering
  • Conclusion: will try to remove all disrodered regions

4. SP removal -> Removing disordered regions -> Filtering -> Foldtree

library(jsonlite)
get_ptm<-function(jsonfile){
  ptm<-fromJSON(jsonfile)$ptm
  return(ptm)
}

df2<-data.frame("input_file" = list.files("../analysis_and_temp_files/03_fold_secretome/colab_fold_best_model", pattern=".json",full.names = T)) %>%
  mutate(TranscriptID = gsub("../analysis_and_temp_files/03_fold_secretome/colab_fold_best_model/(.*)_scores.*$", "\\1", input_file))
df2$ptm<-mapply(get_ptm, df2$input_file)        
get_avg_lddt<-function(input_file){
pdb<-read.pdb(input_file)
avg_lddt<-mean(pdb$atoms$temp)
return(avg_lddt)
}
df$avg_lddt<-mapply(get_avg_lddt, df$input_file) 

pdb_stats<-df2 %>% select(-input_file) %>% left_join(df) %>% select(TranscriptID,ptm,avg_lddt,input_file,last_position_in_SP)
write.table(pdb_stats,"../analysis_and_temp_files/05_cluster_structures/pdb_stats.txt",col.names = T,row.names = F,quote = F,sep="\t")
clip_lddt <- function(input_file,output_file,threshold){
pdb<-read.pdb(input_file)
pdb_subset<-subset(pdb,pdb$atoms$temp>threshold)
write.pdb(pdb_subset,output_file)
rm(pdb,pdb_subset)}

pdb_stats<-read.delim2("../analysis_and_temp_files/05_cluster_structures/pdb_stats.txt")

df3<-data.frame("input_file" = list.files("../analysis_and_temp_files/05_cluster_structures/pdb_signal_removed/", pattern=".pdb",full.names = T)) %>%
  mutate(TranscriptID = gsub("../analysis_and_temp_files/05_cluster_structures/pdb_signal_removed//(.*)_clipped.*$", "\\1", input_file)) %>%
         mutate(output_file = paste0("../analysis_and_temp_files/05_cluster_structures/pdb_SP_removed_clipped_filtered/",TranscriptID,".pdb")) %>%
  filter(TranscriptID %in% pdb_stats$TranscriptID[pdb_stats$ptm>=0.5])
mapply(clip_lddt, df3$input_file,df3$output_file,55)

Defined 83 clusters

  • One cluster (cl24) is split into two, where cl24a is nested within the cl24, which because of it is not monophyletic. Cl24a proteins are bigger than cl24 (maybe duplication?)
  • Most of them have only 2-3 proteins
clusters_df<-read.delim2("../analysis_and_temp_files/05_cluster_structures/clusterin_lddt_clipped_filtered.txt") %>% filter(cluster_id!="")
cluster_info<-clusters_df %>% group_by(cluster_id) %>% summarize(n_proteins=n()) %>% 
  left_join(clusters_df %>% select(-tip) %>% distinct())
cluster_info %>% group_by(n_proteins) %>%summarize(n=n())
## # A tibble: 12 × 2
##    n_proteins     n
##         <int> <int>
##  1          1     1
##  2          2    42
##  3          3    12
##  4          4     8
##  5          5     7
##  6          6     1
##  7          7     2
##  8          8     7
##  9          9     1
## 10         11     1
## 11         12     1
## 12         15     1
  • Visualize
ggplot(cluster_info)+
  geom_histogram(aes(x=n_proteins))

Clusters in different trees

  • Anecdotally, it appears that some ‘clusters’ that I defined based on the lddt tree are also present in the other two trees as monophyletic clades as well (although relationship within these clades and between different clades appear very different)
  • Need to find a way to do this comparison programmatically
  • Test run just one clade:
library(phytools)
lddt<-treeio::read.newick("../analysis_and_temp_files/05_cluster_structures/pdb_SP_removed_clipped_filtered_da39a_0/lddt_struct_tree.nwk")
fold<-treeio::read.newick("../analysis_and_temp_files/05_cluster_structures/pdb_SP_removed_clipped_filtered_da39a_0/foldtree_struct_tree.nwk")
aln<-treeio::read.newick("../analysis_and_temp_files/05_cluster_structures/pdb_SP_removed_clipped_filtered_da39a_0/alntmscore_struct_tree.nwk")

lddt_rooted<-midpoint.root(lddt)
fold_rooted<-midpoint.root(fold)
aln_rooted<-midpoint.root(aln)

clade<-c("FUN_010209-T1","FUN_007256-T1","FUN_005784-T1")
data.frame(rbind(c("lddt","foldtree","aln"),sapply(c(lddt_rooted,fold_rooted,aln_rooted),is.monophyletic,tips=clade)))
##     X1       X2   X3
## 1 lddt foldtree  aln
## 2 TRUE    FALSE TRUE
  • Compared for all clusters
clusters_df<-read.delim2("../analysis_and_temp_files/05_cluster_structures/clusterin_lddt_clipped_filtered.txt") %>% filter(cluster_id!="")
cluster_info<-clusters_df %>% group_by(cluster_id) %>% summarize(n_proteins=n()) %>% 
  left_join(clusters_df %>% select(-tip) %>% distinct())

test_cluster<-function(cl){
  tip_list<-clusters_df$tip[clusters_df$cluster_id==cl]
  l<-is.monophyletic(lddt_rooted,tip_list)
  f<-is.monophyletic(fold_rooted,tip_list)
  a<-is.monophyletic(aln_rooted,tip_list)
  df<-data.frame("cluster_id"=cl,"lDDT"=l,"pTM"=f,"Sequence"=a)
  return(df)
}

l<-lapply(cluster_info$cluster_id,test_cluster)
cluster_info2<-cluster_info %>% left_join(do.call(rbind,l))

cluster_info2 %>%  
  kable(format = "html", col.names = colnames(cluster_info2)) %>%
  kable_styling() %>%
  kableExtra::scroll_box(width = "100%", height = "300px")
cluster_id n_proteins descrition interest lDDT pTM Sequence
cl01 2 Amidase N TRUE TRUE TRUE
cl02 3 Tyrosinase N TRUE FALSE FALSE
cl03 2 No annotation N TRUE FALSE FALSE
cl04 8 No annotation Y TRUE FALSE FALSE
cl05 4 Lipase N TRUE FALSE FALSE
cl06 4 Carboxylesterase N TRUE FALSE FALSE
cl07 4 Esterase N TRUE FALSE TRUE
cl08 2 Annotations do not match N TRUE FALSE FALSE
cl09 5 Peptidase S10P N TRUE FALSE FALSE
cl10 2 Pyrethroid Hydrolase and Hydroxynitrile Lyase N TRUE FALSE FALSE
cl11 3 Lipase N TRUE FALSE TRUE
cl12 2 Esterase N TRUE TRUE TRUE
cl13 3 No annotation N TRUE FALSE FALSE
cl14 2 No annotation N TRUE FALSE FALSE
cl15 8 No annotation N TRUE FALSE FALSE
cl16 2 Ribonuclease/ribotoxin Y TRUE FALSE FALSE
cl17 2 Peptidase S53 N TRUE FALSE TRUE
cl18 6 Match to effector from Zymoseptoria Y TRUE FALSE FALSE
cl19 4 No annotation Y TRUE FALSE FALSE
cl20 7 No annotation Y TRUE FALSE FALSE
cl21 5 Killer toxin Y TRUE FALSE FALSE
cl22 2 No annotation Y TRUE FALSE FALSE
cl23 3 No annotation Y TRUE FALSE FALSE
cl24 9 Match to effector from Zymoseptoria Y FALSE FALSE FALSE
cl24a 11 Match to effector from Zymoseptoria Y TRUE FALSE FALSE
cl25 2 Beta lactamase N TRUE FALSE FALSE
cl26 2 DUF3455 N TRUE FALSE FALSE
cl27 2 Cetoacetate decarboxylase N TRUE FALSE TRUE
cl28 2 Mettalopeptidase N TRUE FALSE FALSE
cl29 4 Extracellular membrane protein N TRUE FALSE FALSE
cl30 3 No annotation N TRUE FALSE FALSE
cl31 4 No annotation N TRUE FALSE FALSE
cl32 12 Mettalopeptidase N TRUE FALSE FALSE
cl33 2 Vacuolar protein sorting-associated protein 62 N TRUE FALSE TRUE
cl34 4 SnoaL N TRUE FALSE FALSE
cl35 2 Annotations do not match N TRUE FALSE FALSE
cl36 2 SUN family N TRUE FALSE FALSE
cl37 2 thaumatin-like Y TRUE FALSE FALSE
cl38 4 thaumatin-like Y TRUE FALSE FALSE
cl39 2 PIR domain N TRUE FALSE FALSE
cl40 2 No annotation N TRUE FALSE TRUE
cl41 3 Ricin B-like lectin N TRUE FALSE TRUE
cl42 1 Match to Trichoderma effector Y TRUE TRUE TRUE
cl43 2 GH43 N TRUE FALSE TRUE
cl44 2 Six-bladed beta-propeller, TolB-like N TRUE FALSE FALSE
cl45 2 Arylsulfotransferase-like N TRUE FALSE TRUE
cl46 3 Annotations do not match N TRUE FALSE FALSE
cl47 2 Germins cupins N TRUE FALSE FALSE
cl48 3 No annotation N TRUE FALSE TRUE
cl49 8 GH16 N TRUE FALSE FALSE
cl50 2 GH12 N TRUE FALSE TRUE
cl51 8 Galactose-binding domain N TRUE FALSE FALSE
cl52 5 No annotation N TRUE FALSE FALSE
cl53 5 Galactose-binding domain Coagulation factor. different otherwise N TRUE FALSE FALSE
cl54 2 Chloroperoxidase N TRUE FALSE FALSE
cl55 3 FAD linked oxidase N TRUE FALSE TRUE
cl56 15 flavoprotein EncM N TRUE FALSE FALSE
cl57 2 SGNH hydrolase domain N TRUE FALSE FALSE
cl58 3 GDSL lipase/esterase N TRUE FALSE FALSE
cl59 5 GH128 N TRUE FALSE FALSE
cl60 2 Spherulation N TRUE FALSE FALSE
cl61 2 GH71 N TRUE FALSE FALSE
cl62 2 GH20 N TRUE TRUE FALSE
cl63 3 GH5 N TRUE FALSE FALSE
cl64 2 GH5 N TRUE FALSE FALSE
cl65 8 GH72 N TRUE FALSE FALSE
cl66 2 No annotation N TRUE FALSE FALSE
cl67 8 Kremen-like N TRUE FALSE FALSE
cl68 2 Ferritin-like N TRUE FALSE TRUE
cl69 2 Purple acid phosphatase-like N TRUE TRUE TRUE
cl70 2 AA9 N TRUE FALSE FALSE
cl71 5 Chitin-binding. matching by small part N TRUE FALSE FALSE
cl72 2 Phosphatidylethanolamine-binding protein N TRUE FALSE FALSE
cl73 2 No annotation N TRUE FALSE FALSE
cl74 2 No annotation N TRUE FALSE TRUE
cl75 2 Endonuclease/exonuclease/phosphatase N TRUE TRUE TRUE
cl76 2 Aminopeptidase M28 N TRUE TRUE TRUE
cl77 2 Patulin synthase N TRUE FALSE FALSE
cl78 7 Cholin/aryl-alcohol oxidase N TRUE FALSE FALSE
cl79 2 No annotation N TRUE FALSE FALSE
cl80 2 Gamma-crystallin-like N TRUE FALSE FALSE
cl81 8 Aspartic peptidase N TRUE FALSE FALSE
cl82 3 No annotation N TRUE FALSE TRUE
cl83 5 Papain inbitor N TRUE FALSE FALSE
  • Most clusters aren’t present in the other trees. Of the 83, clusters 21 are monophyletic in the sequence tree and only 7 in the pTM tree
  • Tracking the clades of interest
    • Clades in the vicinity of Killer toxins: clusters cl18 - cl24
    • In Foldtree they are dispesed throughout
library(ggtree)
library(RColorBrewer)
col_1<-cluster_info %>% mutate(selected = ifelse(
  cluster_id %in% c("cl18","cl19","cl20","cl21","cl22","cl23","cl24","cl24a"),cluster_id,"other")) %>% select(cluster_id,selected)

col_f1<-data.frame("tip"=fold$tip.label) %>% left_join(clusters_df) %>%
  left_join(col_1) 

ggtree(fold,ladderize = TRUE,right = T) %<+% col_f1 +
  geom_tiplab(pch=16,size=3,aes(col=selected))+
  scale_color_manual(values=c("other"="black","cl18"=brewer.pal(n = 8, name = "Dark2")[1],
                              "cl19"=brewer.pal(n = 8, name = "Dark2")[2],
                              "cl20"=brewer.pal(n = 8, name = "Dark2")[3],
                              "cl21"=brewer.pal(n = 8, name = "Dark2")[4],
                              "cl22"=brewer.pal(n = 8, name = "Dark2")[5],
                              "cl23"=brewer.pal(n = 8, name = "Dark2")[6],
                              "cl24"=brewer.pal(n = 8, name = "Dark2")[7],
                              "cl24a"="red"))+
  xlim(0, 1.2)

  • In the sequence tree, there is a bit more structure, and I can see a clade that is mostly comprised of the proteins from these clusters. However, it’s still quite messy. For example, there is a clade ((FUN_009178-T1,FUN_007748-T1),FUN_005533-T1), in which FUN_009178-T1 and FUN_005533-T1 come from cl24 and FUN_007748-T1 is from cl71. As expected, the structure of FUN_007748-T1 looks nothing like the other two. I manually aligned these 3 proteins, and based on this alignment I don’t understand why FUN_009178-T1 and FUN_007748-T1 are grouped together
col_a1<-data.frame("tip"=aln$tip.label) %>% left_join(clusters_df) %>%
  left_join(col_1) 

ggtree(aln,ladderize = TRUE,right = T) %<+% col_a1 +
  geom_tiplab(pch=16,size=3,aes(col=selected))+
  scale_color_manual(values=c("other"="black", #NA="black",
                              "cl18"=brewer.pal(n = 8, name = "Dark2")[1],
                              "cl19"=brewer.pal(n = 8, name = "Dark2")[2],
                              "cl20"=brewer.pal(n = 8, name = "Dark2")[3],
                              "cl21"=brewer.pal(n = 8, name = "Dark2")[4],
                              "cl22"=brewer.pal(n = 8, name = "Dark2")[5],
                              "cl23"=brewer.pal(n = 8, name = "Dark2")[6],
                              "cl24"=brewer.pal(n = 8, name = "Dark2")[7],
                              "cl24a"="red"))+
  xlim(0, 1.2)

  • For comparison, this is the lDDT tree
col_l1<-data.frame("tip"=lddt$tip.label) %>% left_join(clusters_df) %>%
  left_join(col_1) 

ggtree(lddt,ladderize = TRUE,right = T) %<+% col_l1 +
  geom_tiplab(pch=16,size=3,aes(col=selected))+
  scale_color_manual(values=c("other"="black", 
                              "cl18"=brewer.pal(n = 8, name = "Dark2")[1],
                              "cl19"=brewer.pal(n = 8, name = "Dark2")[2],
                              "cl20"=brewer.pal(n = 8, name = "Dark2")[3],
                              "cl21"=brewer.pal(n = 8, name = "Dark2")[4],
                              "cl22"=brewer.pal(n = 8, name = "Dark2")[5],
                              "cl23"=brewer.pal(n = 8, name = "Dark2")[6],
                              "cl24"=brewer.pal(n = 8, name = "Dark2")[7],
                              "cl24a"="red"))+
  xlim(0, 1.2)

  • Result: not sure the sequence-based tree is trustworthy

Running ML tree based on the sequences

  • Make a fasta file that includes only the 393 sequences that are included in the Foldtree analysis
library(Biostrings)
## Warning: package 'S4Vectors' was built under R version 4.1.3
all_fa<-readAAStringSet("../analysis_and_temp_files/01_predicting_effectors/all_secreted.fa")
subset_fa<-all_fa[df3$TranscriptID]
writeXStringSet(subset_fa,"../analysis_and_temp_files/05_cluster_structures/filtered.fa")
  • Align, clip to remove positions missing from >99% of the alignment, and make a ML tree with 1000 rapid bootstraps
sbatch --mem=10G -c 20 --partition=tsl-short --wrap="source package /tgac/software/testing/bin/mafft-7.271; mafft --maxiterate 1000 --genafpair --thread 20  analysis_and_temp_files/05_cluster_structures/filtered.fa >  analysis_and_temp_files/05_cluster_structures/filtered_aligned.fa"

sbatch --mem=10G -c 20 --partition=tsl-short --wrap="source package /tsl/software/testing/bin/trimal-1.2; trimal -in analysis_and_temp_files/05_cluster_structures/filtered_aligned.fa -out analysis_and_temp_files/05_cluster_structures/filtered_aligned.phyl -gt 0.01 -phylip"

sbatch --mem=20G -c 25 --partition=tsl-long --wrap="source package /tgac/software/testing/bin/iqtree-2.2.2.2; iqtree2 -s analysis_and_temp_files/05_cluster_structures/filtered_aligned.phyl -B 1000 -T 25 --threads-max 25"
  • Compare clusters’ status (whether or not it is monophyletic) in thq IQtree
iq<-treeio::read.newick("../analysis_and_temp_files/05_cluster_structures/filtered_aligned.phyl.contree")
iq_rooted<-midpoint.root(iq)

#rename tips in iqtree to make consistent
rename<-data.frame("new"=lddt_rooted$tip.label) %>% mutate(iq_old=sub("-.*", "", new))
rename<-data.frame("iq_old"=iq_rooted$tip.label) %>% left_join(rename)
## Joining with `by = join_by(iq_old)`
iq_rooted$tip.label<-rename$new

#test clusters
test_cluster2<-function(cl){
  tip_list<-clusters_df$tip[clusters_df$cluster_id==cl]
  i<-is.monophyletic(iq_rooted,tip_list)
  l<-is.monophyletic(lddt_rooted,tip_list)
  f<-is.monophyletic(fold_rooted,tip_list)
  a<-is.monophyletic(aln_rooted,tip_list)
  df<-data.frame("cluster_id"=cl,"IQTREE_sequence"=i,"FOldtree_sequence"=a,"lDDT"=l,"pTM"=f)
  return(df)
}

l<-lapply(cluster_info$cluster_id,test_cluster2)
cluster_info3<-cluster_info %>% left_join(do.call(rbind,l))
## Joining with `by = join_by(cluster_id)`
cluster_info3 %>%  
  kable(format = "html", col.names = colnames(cluster_info3)) %>%
  kable_styling() %>%
  kableExtra::scroll_box(width = "100%", height = "300px")
cluster_id n_proteins descrition interest IQTREE_sequence FOldtree_sequence lDDT pTM
cl01 2 Amidase N TRUE TRUE TRUE TRUE
cl02 3 Tyrosinase N FALSE FALSE TRUE FALSE
cl03 2 No annotation N FALSE FALSE TRUE FALSE
cl04 8 No annotation Y FALSE FALSE TRUE FALSE
cl05 4 Lipase N FALSE FALSE TRUE FALSE
cl06 4 Carboxylesterase N FALSE FALSE TRUE FALSE
cl07 4 Esterase N TRUE TRUE TRUE FALSE
cl08 2 Annotations do not match N FALSE FALSE TRUE FALSE
cl09 5 Peptidase S10P N FALSE FALSE TRUE FALSE
cl10 2 Pyrethroid Hydrolase and Hydroxynitrile Lyase N TRUE FALSE TRUE FALSE
cl11 3 Lipase N FALSE TRUE TRUE FALSE
cl12 2 Esterase N TRUE TRUE TRUE TRUE
cl13 3 No annotation N FALSE FALSE TRUE FALSE
cl14 2 No annotation N FALSE FALSE TRUE FALSE
cl15 8 No annotation N FALSE FALSE TRUE FALSE
cl16 2 Ribonuclease/ribotoxin Y FALSE FALSE TRUE FALSE
cl17 2 Peptidase S53 N TRUE TRUE TRUE FALSE
cl18 6 Match to effector from Zymoseptoria Y FALSE FALSE TRUE FALSE
cl19 4 No annotation Y FALSE FALSE TRUE FALSE
cl20 7 No annotation Y FALSE FALSE TRUE FALSE
cl21 5 Killer toxin Y FALSE FALSE TRUE FALSE
cl22 2 No annotation Y FALSE FALSE TRUE FALSE
cl23 3 No annotation Y FALSE FALSE TRUE FALSE
cl24 9 Match to effector from Zymoseptoria Y FALSE FALSE FALSE FALSE
cl24a 11 Match to effector from Zymoseptoria Y FALSE FALSE TRUE FALSE
cl25 2 Beta lactamase N FALSE FALSE TRUE FALSE
cl26 2 DUF3455 N FALSE FALSE TRUE FALSE
cl27 2 Cetoacetate decarboxylase N FALSE TRUE TRUE FALSE
cl28 2 Mettalopeptidase N FALSE FALSE TRUE FALSE
cl29 4 Extracellular membrane protein N TRUE FALSE TRUE FALSE
cl30 3 No annotation N FALSE FALSE TRUE FALSE
cl31 4 No annotation N FALSE FALSE TRUE FALSE
cl32 12 Mettalopeptidase N FALSE FALSE TRUE FALSE
cl33 2 Vacuolar protein sorting-associated protein 62 N TRUE TRUE TRUE FALSE
cl34 4 SnoaL N FALSE FALSE TRUE FALSE
cl35 2 Annotations do not match N FALSE FALSE TRUE FALSE
cl36 2 SUN family N FALSE FALSE TRUE FALSE
cl37 2 thaumatin-like Y TRUE FALSE TRUE FALSE
cl38 4 thaumatin-like Y FALSE FALSE TRUE FALSE
cl39 2 PIR domain N FALSE FALSE TRUE FALSE
cl40 2 No annotation N FALSE TRUE TRUE FALSE
cl41 3 Ricin B-like lectin N FALSE TRUE TRUE FALSE
cl42 1 Match to Trichoderma effector Y TRUE TRUE TRUE TRUE
cl43 2 GH43 N FALSE TRUE TRUE FALSE
cl44 2 Six-bladed beta-propeller, TolB-like N FALSE FALSE TRUE FALSE
cl45 2 Arylsulfotransferase-like N TRUE TRUE TRUE FALSE
cl46 3 Annotations do not match N FALSE FALSE TRUE FALSE
cl47 2 Germins cupins N FALSE FALSE TRUE FALSE
cl48 3 No annotation N TRUE TRUE TRUE FALSE
cl49 8 GH16 N FALSE FALSE TRUE FALSE
cl50 2 GH12 N FALSE TRUE TRUE FALSE
cl51 8 Galactose-binding domain N FALSE FALSE TRUE FALSE
cl52 5 No annotation N FALSE FALSE TRUE FALSE
cl53 5 Galactose-binding domain Coagulation factor. different otherwise N FALSE FALSE TRUE FALSE
cl54 2 Chloroperoxidase N FALSE FALSE TRUE FALSE
cl55 3 FAD linked oxidase N TRUE TRUE TRUE FALSE
cl56 15 flavoprotein EncM N FALSE FALSE TRUE FALSE
cl57 2 SGNH hydrolase domain N FALSE FALSE TRUE FALSE
cl58 3 GDSL lipase/esterase N TRUE FALSE TRUE FALSE
cl59 5 GH128 N FALSE FALSE TRUE FALSE
cl60 2 Spherulation N TRUE FALSE TRUE FALSE
cl61 2 GH71 N FALSE FALSE TRUE FALSE
cl62 2 GH20 N TRUE FALSE TRUE TRUE
cl63 3 GH5 N TRUE FALSE TRUE FALSE
cl64 2 GH5 N FALSE FALSE TRUE FALSE
cl65 8 GH72 N FALSE FALSE TRUE FALSE
cl66 2 No annotation N FALSE FALSE TRUE FALSE
cl67 8 Kremen-like N FALSE FALSE TRUE FALSE
cl68 2 Ferritin-like N FALSE TRUE TRUE FALSE
cl69 2 Purple acid phosphatase-like N TRUE TRUE TRUE TRUE
cl70 2 AA9 N FALSE FALSE TRUE FALSE
cl71 5 Chitin-binding. matching by small part N FALSE FALSE TRUE FALSE
cl72 2 Phosphatidylethanolamine-binding protein N FALSE FALSE TRUE FALSE
cl73 2 No annotation N FALSE FALSE TRUE FALSE
cl74 2 No annotation N TRUE TRUE TRUE FALSE
cl75 2 Endonuclease/exonuclease/phosphatase N TRUE TRUE TRUE TRUE
cl76 2 Aminopeptidase M28 N TRUE TRUE TRUE TRUE
cl77 2 Patulin synthase N TRUE FALSE TRUE FALSE
cl78 7 Cholin/aryl-alcohol oxidase N FALSE FALSE TRUE FALSE
cl79 2 No annotation N FALSE FALSE TRUE FALSE
cl80 2 Gamma-crystallin-like N FALSE FALSE TRUE FALSE
cl81 8 Aspartic peptidase N FALSE FALSE TRUE FALSE
cl82 3 No annotation N TRUE TRUE TRUE FALSE
cl83 5 Papain inbitor N FALSE FALSE TRUE FALSE
  • In the IQtree version of sequence-based tree, the number of clusters that come as monophyletic is higher by one (n=22)
  • Looking at the IQtree, compared to the alntm tree, it’s more consistent in some parts and less consistent in others. Probably, it’s better to stick to the FOoldtree output
col_i1<-data.frame("tip"=iq_rooted$tip.label) %>% left_join(clusters_df) %>%
  left_join(col_1) 

ggtree(iq_rooted,ladderize = TRUE,right = T) %<+% col_i1 +
  geom_tiplab(pch=16,size=3,aes(col=selected))+
  scale_color_manual(values=c("other"="black", 
                              "cl18"=brewer.pal(n = 8, name = "Dark2")[1],
                              "cl19"=brewer.pal(n = 8, name = "Dark2")[2],
                              "cl20"=brewer.pal(n = 8, name = "Dark2")[3],
                              "cl21"=brewer.pal(n = 8, name = "Dark2")[4],
                              "cl22"=brewer.pal(n = 8, name = "Dark2")[5],
                              "cl23"=brewer.pal(n = 8, name = "Dark2")[6],
                              "cl24"=brewer.pal(n = 8, name = "Dark2")[7],
                              "cl24a"="red"))+
  xlim(0, 5)+geom_treescale()

5. Summarizinig clustering results

ann<-read.delim("../analysis_and_temp_files/04_characterize_secretome/secretome_annotations.txt")

clusters_df$TranscriptID <- str_replace(clusters_df$tip,"FUN","XANPAGTX0501")
pdb_stats$TranscriptID <- str_replace(pdb_stats$TranscriptID,"FUN","XANPAGTX0501")

size<-data.frame("size"=width(all_fa),"name"=names(all_fa))
size$TranscriptID <- str_replace(size$name,"FUN","XANPAGTX0501")

combined<-ann %>% left_join(clusters_df) %>% left_join(pdb_stats) %>% left_join(size) %>%
  select(TranscriptID,cluster_id,descrition,DGE,ptm,pLDDT,size,InterPro,CAZyme_new,Protease_new,antimicrobial,pdb_best,pdb_second,af_best,af_second) %>%
  mutate(cluster_id = case_when(is.na(cluster_id) & ptm>=0.5 ~ "not in cluster",
   is.na(cluster_id) & ptm<0.5 ~ "pTM below threshold",                         
    T ~ cluster_id)) %>% arrange(cluster_id) 
colnames(combined)<-c("ProteinID","ClusterID","CLuster_Description","Gene_Expression",
                      "pTM_Score", "Average_pLDDT", "Size_aa", "InterPro", "CAZyme_new","Protease_new","Antimicrobial_activity_prediction","Best_match_PDB","Second_match_PDB","Best_match_AF","Second_match_AF")

write.table(combined,"../analysis_and_temp_files/05_cluster_structures/clustering_results.txt",col.names = T,row.names = F,quote = F,sep="\t")

combined %>%  
  kable(format = "html", col.names = colnames(combined)) %>%
  kable_styling() %>%
  kableExtra::scroll_box(width = "100%", height = "300px")
ProteinID ClusterID CLuster_Description Gene_Expression pTM_Score Average_pLDDT Size_aa InterPro CAZyme_new Protease_new Antimicrobial_activity_prediction Best_match_PDB Second_match_PDB Best_match_AF Second_match_AF
XANPAGTX0501_001769-T1 cl01 Amidase Non-DGE 0.92 92.03780 644 IPR023631 Amidase signature domain;IPR036928 Amidase signature (AS) superfamily NA NA Non-antimicrobial 1OBL; crystal structure of the S133A mutant of Malonamidase E2 complexed with malonate from Bradyrhizobium japonicum; 1.039e-22 1OCK; THE CRYSTAL STRUCTURE OF MALONAMIDASE E2 FROM BRADYRHIZOBIUM JAPONICUM; 7.681e-22 A0A1V8UQ83; Amidase domain-containing protein; Rachicladosporium sp. CCFEE 5018; 1.283e-90 A0A1F5LL44; Amidase domain-containing protein; Penicillium arizonense; 1.425e-75
XANPAGTX0501_010624-T1 cl01 Amidase Upregulated in lichen 0.92 92.40121 652 IPR023631 Amidase signature domain;IPR036928 Amidase signature (AS) superfamily NA NA Antimicrobial 2DC0; Crystal structure of amidase; 1.145e-21 1OBL; crystal structure of the S133A mutant of Malonamidase E2 complexed with malonate from Bradyrhizobium japonicum; 1.916e-21 L7J9U7; Glutamyl-tRNA(Gln) amidotransferase; Pyricularia oryzae (strain P131) (Rice blast fungus) (Magnaporthe oryzae); 4.605e-77 A0A4Y9XTD4; Amidase domain-containing protein; Rhodofomes roseus; 2.156e-76
XANPAGTX0501_001150-T1 cl02 Tyrosinase Non-DGE 0.91 90.56552 598 IPR002227 Tyrosinase copper-binding domain;IPR008922 Di-copper centre-containing domain superfamily;IPR041640 Tyosinase, C-terminal NA NA Non-antimicrobial 4OUA; Coexistent single-crystal structure of latent and active mushroom tyrosinase (abPPO4) mediated by a hexatungstotellurate(VI); 1.152e-36 5M6B; structure of recombinant mushroom tyrosinase (abPPO4); 8.655e-36 A0A232M6A5; tyrosinase (EC 1.14.18.1); Elaphomyces granulatus; 4.536e-59 U1HZ89; tyrosinase (EC 1.14.18.1); Endocarpon pusillum (strain Z07020 / HMAS-L-300199) (Lichen-forming fungus); 1.573e-56
XANPAGTX0501_003876-T1 cl02 Tyrosinase Non-DGE 0.9 92.56312 381 IPR002227 Tyrosinase copper-binding domain;IPR008922 Di-copper centre-containing domain superfamily NA NA Non-antimicrobial 5OR3; Crystal structure of Aspergillus oryzae catechol oxidase in met/deoxy-form; 9.865e-36 4J3Q; Crystal structure of truncated catechol oxidase from Aspergillus oryzae; 1.012e-33 A0A1L7XJB2; Related to monophenol monooxygenase (Tyrosinase); Phialocephala subalpina; 3.877e-35 A0A6A6W082; Tyrosinase; Pseudovirgaria hyperparasitica; 1.885e-34
XANPAGTX0501_004818-T1 cl02 Tyrosinase Non-DGE 0.82 83.06497 294 IPR002227 Tyrosinase copper-binding domain;IPR008922 Di-copper centre-containing domain superfamily NA NA Antimicrobial 5M6B; structure of recombinant mushroom tyrosinase (abPPO4); 1.623e-14 6JUD; Radiation damage in Aspergillus oryzae pro-tyrosinase oxygen-bound C92A/H103F mutant; 1.781e-13 A0A5M8PXI5; tyrosinase (EC 1.14.18.1); Lasallia pustulata; 1.841e-22 A0A1Y1ZT51; Common central domain of tyrosinase-domain-containing protein; Clohesyomyces aquaticus; 2.572e-22
XANPAGTX0501_001123-T1 cl03 No annotation Non-DGE 0.51 68.40650 203 NA NA NA Non-antimicrobial NA NA A0A0K8L317; deleted; ; 9.48e-14 A0A5M9M9I3; 4Fe-4S ferredoxin-type domain-containing protein; Aspergillus tanneri; 2.749e-13
XANPAGTX0501_003936-T1 cl03 No annotation Non-DGE 0.5 69.73432 192 NA NA NA Non-antimicrobial NA NA A0A165K0S4; PCI domain-containing protein; Xylona heveae (strain CBS 132557 / TC161); 2.041e-09 A0A1W5DB61; Uncharacterized protein; Lasallia pustulata; 5.797e-09
XANPAGTX0501_000516-T1 cl04 No annotation Non-DGE 0.54 53.96782 298 NA NA NA Below pLDDT threshold NA NA A0A177DZ91; Uncharacterized protein; Alternaria alternata (Alternaria rot fungus) (Torula alternata); 2.617e-08 A0A4Q4QFQ8; deleted; ; 4.084e-08
XANPAGTX0501_002012-T1 cl04 No annotation Non-DGE 0.62 60.28573 295 NA NA NA Below pLDDT threshold NA NA A0A194X1P8; Uncharacterized protein; Mollisia scopiformis (Conifer needle endophyte fungus) (Phialocephala scopiformis); 8.6e-14 A0A384JZK1; Uncharacterized protein; Botryotinia fuckeliana (strain B05.10) (Noble rot fungus) (Botrytis cinerea); 5.239e-12
XANPAGTX0501_002315-T2 cl04 No annotation Upregulated in lichen 0.63 58.00690 316 NA NA NA Below pLDDT threshold NA NA A0A1Y1YB21; Uncharacterized protein; Clohesyomyces aquaticus; 8.593e-08 A0A4Q4SRX6; Uncharacterized protein; Alternaria arborescens; 1.329e-07
XANPAGTX0501_003678-T1 cl04 No annotation Non-DGE 0.81 79.67219 274 NA NA NA Non-antimicrobial NA NA A0A7C8MK18; Uncharacterized protein; Massariosphaeria phaeospora; 6.646e-11 A0A194X1P8; Uncharacterized protein; Mollisia scopiformis (Conifer needle endophyte fungus) (Phialocephala scopiformis); 9.511e-11
XANPAGTX0501_005039-T1 cl04 No annotation Non-DGE 0.69 65.00582 282 NA NA NA Non-antimicrobial NA NA A0A1V8SC36; Uncharacterized protein; Rachicladosporium antarcticum; 6.292e-09 A0A1V8VA03; Uncharacterized protein; Rachicladosporium sp. CCFEE 5018; 9.701e-09
XANPAGTX0501_005768-T1 cl04 No annotation Non-DGE 0.65 62.55987 301 NA NA NA Below pLDDT threshold NA NA A0A4Z1GB68; Uncharacterized protein; Botrytis hyacinthi; 5.298e-09 A0A4Z1HMH8; Uncharacterized protein; Botryotinia convoluta; 1.316e-08
XANPAGTX0501_009148-T1 cl04 No annotation Non-DGE 0.55 51.94609 289 NA NA NA Below pLDDT threshold NA NA A0A0F7U4N9; Uncharacterized protein; Penicillium brasilianum; 2.078e-08 A0A7J6IN97; Uncharacterized protein; Colletotrichum fructicola (strain Nara gc5) (Anthracnose fungus) (Colletotrichum gloeosporioides (strain Nara gc5)); 2.075e-06
XANPAGTX0501_010247-T1 cl04 No annotation Upregulated in lichen 0.69 65.92789 331 NA NA NA Non-antimicrobial NA NA A0A6A7BBL6; Uncharacterized protein; Plenodomus tracheiphilus IPT5; 2.921e-15 E5A2A2; Uncharacterized protein; Leptosphaeria maculans (strain JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8) (Blackleg fungus) (Phoma lingam); 5.012e-13
XANPAGTX0501_002910-T1 cl05 Lipase Non-DGE 0.76 74.32514 391 IPR002921 Fungal lipase-like domain;IPR029058 Alpha/Beta hydrolase fold NA NA Non-antimicrobial 3O0D; Crystal structure of Lip2 lipase from Yarrowia lipolytica at 1.7 A resolution; 4.744e-24 3O0D; Crystal structure of Lip2 lipase from Yarrowia lipolytica at 1.7 A resolution; 2.429e-23 A0A5J5ERY1; Alpha/Beta hydrolase protein; Sphaerosporella brunnea; 6.083e-37 A0A2C5ZFB3; Fungal lipase-like domain-containing protein; Ophiocordyceps australis; 3.472e-33
XANPAGTX0501_005151-T1 cl05 Lipase Non-DGE 0.83 82.60072 318 IPR002921 Fungal lipase-like domain;IPR005592 Mono-/di-acylglycerol lipase, N-terminal;IPR029058 Alpha/Beta hydrolase fold NA NA Non-antimicrobial 5CH8; Crystal structure of MDLA N225Q mutant form Penicillium cyclopium; 1.01e-27 1TIA; AN UNUSUAL BURIED POLAR CLUSTER IN A FAMILY OF FUNGAL LIPASES; 2.47e-23 A0A151GN20; Fungal lipase-like domain-containing protein; Drechmeria coniospora; 3.859e-27 A0A4Q0A149; Alpha/Beta hydrolase protein; Dimargaris cristalligena; 2.738e-21
XANPAGTX0501_005200-T1 cl05 Lipase Non-DGE 0.86 88.66610 310 IPR002921 Fungal lipase-like domain;IPR005592 Mono-/di-acylglycerol lipase, N-terminal;IPR029058 Alpha/Beta hydrolase fold NA NA Non-antimicrobial 1DU4; THE STRUCTURAL ORIGINS OF INTERFACIAL ACTIVATION IN THERMOMYCES (HUMICOLA) LANUGINOSA LIPASE OTHER STRUCTURE DETAILS; 1.208e-31 5XK2; Crystal structure of mono- and diacylglycerol lipase from Aspergillus oryzae; 4.332e-31 M2VDZ6; Fungal lipase-like domain-containing protein; Cochliobolus heterostrophus (strain C5 / ATCC 48332 / race O) (Southern corn leaf blight fungus) (Bipolaris maydis); 1.614e-40 A0A2T2P6Z2; Alpha/beta-hydrolase; Corynespora cassiicola Philippines; 2.649e-39
XANPAGTX0501_007071-T1 cl05 Lipase Non-DGE 0.66 69.82050 604 IPR002921 Fungal lipase-like domain;IPR029058 Alpha/Beta hydrolase fold NA NA Antimicrobial NA NA A0A1V6U163; triacylglycerol lipase (EC 3.1.1.3) (Autophagy-related protein 15); Penicillium steckii; 6.163e-51 A0A165GXK6; triacylglycerol lipase (EC 3.1.1.3) (Autophagy-related protein 15); Xylona heveae (strain CBS 132557 / TC161); 1.017e-48
XANPAGTX0501_003746-T1 cl06 Carboxylesterase Non-DGE 0.92 93.16333 559 IPR002018 Carboxylesterase, type B;IPR019819 Carboxylesterase type B, conserved site;IPR019826 Carboxylesterase type B, active site;IPR029058 Alpha/Beta hydrolase fold NA S09X Non-antimicrobial 1C7I; THERMOPHYLIC PNB ESTERASE; 5.855e-38 1QE3; PNB ESTERASE; 2.791e-37 A0A0D2GVE1; Carboxylic ester hydrolase (EC 3.1.1.-); Fonsecaea pedrosoi CBS 271.37; 7.64e-80 W9X4S7; Zn(2)-C6 fungal-type domain-containing protein; Cladophialophora psammophila CBS 110553; 1.881e-70
XANPAGTX0501_004372-T1 cl06 Carboxylesterase Upregulated in lichen 0.91 89.42864 581 IPR002018 Carboxylesterase, type B;IPR029058 Alpha/Beta hydrolase fold NA S09X Non-antimicrobial 1UKC; Crystal Structure of Aspergillus niger EstA; 3.901e-40 1LLF; Cholesterol Esterase (Candida Cylindracea) Crystal Structure at 1.4A resolution; 3.298e-35 A0A1Y2DQ58; Alpha/Beta hydrolase protein; Pseudomassariella vexata; 2.91e-67 A0A2N3NG78; Carboxylesterase type B domain-containing protein; Lomentospora prolificans; 2.748e-66
XANPAGTX0501_008841-T1 cl06 Carboxylesterase Non-DGE 0.89 87.54931 507 IPR002018 Carboxylesterase, type B;IPR019826 Carboxylesterase type B, active site;IPR029058 Alpha/Beta hydrolase fold NA S09X Non-antimicrobial 6EMI; Crystal structure of a variant of human butyrylcholinesterase expressed in bacteria.; 1.413e-37 2WSL; Aged Form of Human Butyrylcholinesterase Inhibited by Tabun Analogue TA4; 1.622e-36 W6YBH2; Carboxylic ester hydrolase (EC 3.1.1.-); Cochliobolus carbonum (strain 26-R-13) (Maize leaf spot fungus) (Bipolaris zeicola); 1.318e-76 A0A0A2IML7; Carboxylic ester hydrolase (EC 3.1.1.-); Penicillium expansum (Blue mold rot fungus); 9.628e-66
XANPAGTX0501_010387-T1 cl06 Carboxylesterase Non-DGE 0.91 89.53768 629 IPR002018 Carboxylesterase, type B;IPR019819 Carboxylesterase type B, conserved site;IPR019826 Carboxylesterase type B, active site;IPR029058 Alpha/Beta hydrolase fold NA S09X Non-antimicrobial 1UKC; Crystal Structure of Aspergillus niger EstA; 1.105e-40 5TYM; alpha-esterase-7 in complex with [3-bromo-5-(pyrrolidin-1-yl)phenyl]borinic acid; 2.15e-28 A0A2N3NJP6; Carboxylic ester hydrolase (EC 3.1.1.-); Lomentospora prolificans; 1.199e-77 A0A175W3Y4; Carboxylic ester hydrolase (EC 3.1.1.-); Madurella mycetomatis; 1.271e-77
XANPAGTX0501_004947-T1 cl07 Esterase Non-DGE 0.75 75.97718 280 IPR029058 Alpha/Beta hydrolase fold NA NA Non-antimicrobial 4Q34; Crystal structure of a putative esterase (BDI_1566) from Parabacteroides distasonis ATCC 8503 at 1.60 A resolution; 7.096e-12 8J7J; crystal structure of SulE mutant; 2.396e-10 A0A2S7R5N2; Alpha beta-hydrolase protein; Rutstroemia sp. NJR-2017a WRK4; 1.305e-26 A0A5M9J6M4; AB hydrolase-1 domain-containing protein; Monilinia fructicola (Brown rot fungus) (Ciboria fructicola); 5.539e-26
XANPAGTX0501_005390-T1 cl07 Esterase Non-DGE 0.85 82.22738 370 IPR000073 Alpha/beta hydrolase fold-1;IPR029058 Alpha/Beta hydrolase fold NA NA Non-antimicrobial 7Y0L; SulE-S209A; 6.17e-17 8GOY; SulE P44R; 2.948e-16 A0A5M9MXD6; Uncharacterized protein; Aspergillus tanneri; 1.183e-36 W3X8Z8; Uncharacterized protein; Pestalotiopsis fici (strain W106-1 / CGMCC3.15140); 1.481e-35
XANPAGTX0501_009613-T1 cl07 Esterase Upregulated in culture 0.87 89.68830 411 IPR000073 Alpha/beta hydrolase fold-1;IPR029058 Alpha/Beta hydrolase fold NA NA Non-antimicrobial 2WKW; Alcaligenes esterase complexed with product analogue; 2.269e-18 2XMR; Crystal structure of human NDRG2 protein provides insight into its role as a tumor suppressor; 1.238e-05 A0A4S9HIU3; Alpha/beta-hydrolase; Aureobasidium pullulans (Black yeast) (Pullularia pullulans); 3.139e-58 W3XMF4; AB hydrolase-1 domain-containing protein; Pestalotiopsis fici (strain W106-1 / CGMCC3.15140); 2.594e-56
XANPAGTX0501_009663-T1 cl07 Esterase Non-DGE 0.87 90.03199 396 IPR029058 Alpha/Beta hydrolase fold NA NA Non-antimicrobial 7Y0L; SulE-S209A; 5.344e-21 8J7J; crystal structure of SulE mutant; 6.404e-21 A0A6G1JNZ9; Alpha/beta-hydrolase; Lentithecium fluviatile CBS 122367; 1.496e-43 A0A5M9MXD6; Uncharacterized protein; Aspergillus tanneri; 5.64e-43
XANPAGTX0501_002987-T1 cl08 Annotations do not match Non-DGE 0.9 92.13380 502 IPR000073 Alpha/beta hydrolase fold-1;IPR029058 Alpha/Beta hydrolase fold NA S33 Non-antimicrobial 5UGQ; Crystal Structure of Hip1 (Rv2224c); 7.392e-29 5BKM; Crystal Structure of Hip1 (Rv2224c) mutant - S228DHA (dehydroalanine); 1.067e-28 A0A517LJC5; AB hydrolase-1 domain-containing protein; Venturia effusa; 3.629e-54 A0A319E729; Uncharacterized protein; Aspergillus sclerotiicarbonarius (strain CBS 121057 / IBT 28362); 5.829e-53
XANPAGTX0501_003285-T1 cl08 Annotations do not match Upregulated in lichen 0.89 91.59657 545 IPR008758 Peptidase S28;IPR029058 Alpha/Beta hydrolase fold;IPR042269 Serine carboxypeptidase S28, SKS domain NA S28 Antimicrobial 7WAB; Crystal structure of the prolyl endoprotease, PEP, from Aspergillus niger; 3.561e-30 3JYH; Human dipeptidyl peptidase DPP7; 2.669e-20 A0A0J8R059; Uncharacterized protein; Coccidioides immitis RMSCC 3703; 6.685e-63 A0A6H0XQH2; Serine carboxypeptidase S28; Peltaster fructicola; 1.192e-60
XANPAGTX0501_000182-T1 cl09 Peptidase S10P Non-DGE 0.88 88.12758 549 IPR001563 Peptidase S10, serine carboxypeptidase;IPR008442 Propeptide, carboxypeptidase Y;IPR018202 Serine carboxypeptidase, serine active site;IPR029058 Alpha/Beta hydrolase fold NA S10 Antimicrobial 1YSC; 2.8 ANGSTROMS STRUCTURE OF YEAST SERINE CARBOXYPEPTIDASE; 5.144e-57 1CPY; SITE-DIRECTED MUTAGENESIS ON (SERINE) CARBOXYPEPTIDASE Y FROM YEAST. THE SIGNIFICANCE OF THR 60 AND MET 398 IN HYDROLYSIS AND AMINOLYSIS REACTIONS; 3.598e-56 A0A1R3S1F9; Carboxypeptidase (EC 3.4.16.-); Aspergillus carbonarius (strain ITEM 5010); 3.931e-87 A0A7T7BNH1; Carboxypeptidase (EC 3.4.16.-); Penicillium digitatum (Green mold); 1.951e-86
XANPAGTX0501_000540-T1 cl09 Peptidase S10P Non-DGE 0.88 90.25310 577 IPR001563 Peptidase S10, serine carboxypeptidase;IPR018202 Serine carboxypeptidase, serine active site;IPR029058 Alpha/Beta hydrolase fold NA S10 Antimicrobial 1YSC; 2.8 ANGSTROMS STRUCTURE OF YEAST SERINE CARBOXYPEPTIDASE; 8.707e-35 1CPY; SITE-DIRECTED MUTAGENESIS ON (SERINE) CARBOXYPEPTIDASE Y FROM YEAST. THE SIGNIFICANCE OF THR 60 AND MET 398 IN HYDROLYSIS AND AMINOLYSIS REACTIONS; 3.248e-33 A0A3M7P144; Carboxypeptidase (EC 3.4.16.-); Chaetothyriales sp. CBS 134916; 3.571e-80 A0A179UWX9; Carboxypeptidase (EC 3.4.16.-); Blastomyces gilchristii (strain SLH14081) (Blastomyces dermatitidis); 1.264e-73
XANPAGTX0501_008146-T1 cl09 Peptidase S10P Upregulated in lichen 0.88 87.83462 506 IPR001563 Peptidase S10, serine carboxypeptidase;IPR018202 Serine carboxypeptidase, serine active site;IPR029058 Alpha/Beta hydrolase fold NA S10 Non-antimicrobial 4CI9; Crystal structure of cathepsin A, apo-structure; 6.196e-31 1IVY; PHYSIOLOGICAL DIMER HPP PRECURSOR; 4.587e-30 A0A1W5DCK7; Carboxypeptidase (EC 3.4.16.-); Lasallia pustulata; 3.809e-66 A0A094AVS9; Carboxypeptidase (EC 3.4.16.-); Pseudogymnoascus sp. VKM F-4281 (FW-2241); 2.688e-48
XANPAGTX0501_009239-T1 cl09 Peptidase S10P Non-DGE 0.86 86.90514 677 IPR001563 Peptidase S10, serine carboxypeptidase;IPR018202 Serine carboxypeptidase, serine active site;IPR029058 Alpha/Beta hydrolase fold;IPR033124 Serine carboxypeptidases, histidine active site NA S10 Antimicrobial 4CIB; crystal structure of cathepsin a, complexed with compound 2; 2.142e-26 4CI9; Crystal structure of cathepsin A, apo-structure; 2.6e-25 A0A364LCY0; Major facilitator superfamily (MFS) profile domain-containing protein; Talaromyces amestolkiae; 1.375e-85 A0A0A2JXA2; Poly [ADP-ribose] polymerase (PARP) (EC 2.4.2.-); Penicillium expansum (Blue mold rot fungus); 2.939e-85
XANPAGTX0501_009986-T1 cl09 Peptidase S10P Non-DGE 0.9 91.46279 551 IPR001563 Peptidase S10, serine carboxypeptidase;IPR018202 Serine carboxypeptidase, serine active site;IPR029058 Alpha/Beta hydrolase fold NA S10 Antimicrobial 4MWS; Crystal structure of human PPCA (trigonal crystal form 1); 6.332e-28 4CI9; Crystal structure of cathepsin A, apo-structure; 3.404e-27 A0A1S1VAN8; deleted; ; 4.902e-78 A0A3M7MD23; Carboxypeptidase (EC 3.4.16.-); Pyrenophora seminiperda CCB06; 2.635e-77
XANPAGTX0501_009724-T1 cl10 Pyrethroid Hydrolase and Hydroxynitrile Lyase Non-DGE 0.85 90.04939 295 IPR000073 Alpha/beta hydrolase fold-1;IPR029058 Alpha/Beta hydrolase fold NA NA Non-antimicrobial 5Y5R; Crystal structure of a novel Pyrethroid Hydrolase PytH with BIF; 5.077e-16 5Y51; Crystal structure of PytH_H230A; 5.776e-16 A0A1Y1Y4L9; Alpha/beta hydrolase fold-1; Clohesyomyces aquaticus; 1.027e-39 A0A2V1D9L3; Alpha/beta-hydrolase; Periconia macrospinosa; 1.513e-39
XANPAGTX0501_009860-T1 cl10 Pyrethroid Hydrolase and Hydroxynitrile Lyase Non-DGE 0.85 90.14534 294 IPR000073 Alpha/beta hydrolase fold-1;IPR029058 Alpha/Beta hydrolase fold NA NA Antimicrobial 5TDX; Resurrected Ancestral Hydroxynitrile Lyase from Flowering Plants; 8.805e-13 5Y5V; Crystal structure of a novel Pyrethroid Hydrolase PytH (S78A); 2.03e-11 A0A2V1D9L3; Alpha/beta-hydrolase; Periconia macrospinosa; 2.057e-39 A0A1Y1Y4L9; Alpha/beta hydrolase fold-1; Clohesyomyces aquaticus; 3.071e-39
XANPAGTX0501_002310-T1 cl11 Lipase Non-DGE 0.91 92.19912 443 IPR029058 Alpha/Beta hydrolase fold NA NA Non-antimicrobial 5HDP; Hydrolase StnA mutant - S185A; 5.498e-23 5HDF; Hydrolase SeMet-StnA; 3.486e-22 A0A4S9HNV5; Alpha/beta-hydrolase; Aureobasidium pullulans (Black yeast) (Pullularia pullulans); 1.305e-65 R1GBW7; Putative alpha beta-hydrolase protein; Botryosphaeria parva (strain UCR-NP2) (Grapevine canker fungus) (Neofusicoccum parvum); 8.157e-52
XANPAGTX0501_003835-T1 cl11 Lipase Non-DGE 0.85 86.10993 428 IPR000073 Alpha/beta hydrolase fold-1;IPR029058 Alpha/Beta hydrolase fold NA NA Antimicrobial 5HDP; Hydrolase StnA mutant - S185A; 5.02e-25 5HDF; Hydrolase SeMet-StnA; 1.597e-24 A0A2H2ZMS4; Esterase; Trichoderma parareesei (Filamentous fungus); 1.24e-55 A0A6A5TNI9; Alpha/beta-hydrolase; Byssothecium circinans; 6.672e-54
XANPAGTX0501_005856-T1 cl11 Lipase Non-DGE 0.87 85.57917 396 IPR000073 Alpha/beta hydrolase fold-1;IPR029058 Alpha/Beta hydrolase fold NA NA Antimicrobial 5HDP; Hydrolase StnA mutant - S185A; 1.598e-21 5HDF; Hydrolase SeMet-StnA; 3.803e-21 A0A165FUN5; AB hydrolase-1 domain-containing protein; Exidia glandulosa HHB12029; 1.962e-31 A0A4V6S1T3; (4-O-methyl)-D-glucuronate–lignin esterase (EC 3.1.1.117); Antrodiella citrinella; 9.033e-29
XANPAGTX0501_003182-T1 cl12 Esterase Non-DGE 0.9 91.96087 469 IPR005152 Lipase, secreted;IPR022742 Serine aminopeptidase, S33;IPR029058 Alpha/Beta hydrolase fold NA NA Non-antimicrobial 3H2I; Crystal structure of N228W mutant of the rice cell wall degrading esterase LipA from Xanthomonas oryzae; 1.997e-18 3H2J; Crystal structure of the rice cell wall degrading esterase LipA from Xanthomonas oryzae; 4.028e-18 A0A6A6ULT3; Prolyl aminopeptidase-like protein; Microthyrium microscopicum; 2.63e-58 A0A178B9N1; Alpha/beta-hydrolase; Stagonospora sp. SRC1lsM3a; 9.082e-53
XANPAGTX0501_009609-T1 cl12 Esterase Upregulated in culture 0.91 92.02805 476 IPR000073 Alpha/beta hydrolase fold-1;IPR005152 Lipase, secreted;IPR029058 Alpha/Beta hydrolase fold NA NA Non-antimicrobial 3H2J; Crystal structure of the rice cell wall degrading esterase LipA from Xanthomonas oryzae; 1.046e-17 3H2G; Crystal structure of a rice cell wall degrading esterase LipA from Xanthomonas oryzae; 1.89e-17 A0A6A6ULT3; Prolyl aminopeptidase-like protein; Microthyrium microscopicum; 1.231e-54 A0A178B9N1; Alpha/beta-hydrolase; Stagonospora sp. SRC1lsM3a; 1.413e-50
XANPAGTX0501_002540-T1 cl13 No annotation Non-DGE 0.9 92.84221 434 IPR010520 Esterase FrsA-like;IPR029058 Alpha/Beta hydrolase fold NA NA Antimicrobial 3FNB; Crystal structure of acylaminoacyl peptidase SMU_737 from Streptococcus mutans UA159; 1.4e-20 3FNB; Crystal structure of acylaminoacyl peptidase SMU_737 from Streptococcus mutans UA159; 1.526e-19 A0A0N1NX87; AB hydrolase-1 domain-containing protein; Phialophora attinorum; 3.535e-54 A0A5C6G0M3; Peptidase S9 prolyl oligopeptidase catalytic domain-containing protein; Metarhizium rileyi; 1.373e-43
XANPAGTX0501_004433-T1 cl13 No annotation Non-DGE 0.92 94.86553 714 IPR001375 Peptidase S9, prolyl oligopeptidase, catalytic domain;IPR011042 Six-bladed beta-propeller, TolB-like;IPR011659 WD40-like beta propeller;IPR029058 Alpha/Beta hydrolase fold NA S09C Antimicrobial 5YZO; Crystal structure of S9 peptidase mutant (S514A) from Deinococcus radiodurans R1; 5.984e-35 6IKG; Crystal structure of substrate-bound S9 peptidase (S514A mutant) from Deinococcus radiodurans; 1.509e-34 A0A4Q4V310; Dipeptidyl-peptidase V; Monosporascus sp. MC13-8B; 0 A0A3M0W227; Dipeptidyl-peptidase V; Chaetothyriales sp. CBS 134920; 0
XANPAGTX0501_006949-T1 cl13 No annotation Non-DGE 0.84 84.77185 329 IPR000073 Alpha/beta hydrolase fold-1;IPR029058 Alpha/Beta hydrolase fold NA S33 Non-antimicrobial 6I8W; Crystal structure of a membrane phospholipase A, a novel bacterial virulence factor; 2.061e-14 8CKP; X-ray structure of the crystallization-prone form of subfamily III haloalkane dehalogenase DhmeA from Haloferax mediterranei; 4.295e-14 A0A0D2BFI4; AB hydrolase-1 domain-containing protein; Exophiala spinifera; 2.246e-45 A0A1N6RDX9; Pimeloyl-ACP methyl ester carboxylesterase; Rhizobium sp. RU20A; 6.038e-23
XANPAGTX0501_003976-T1 cl14 No annotation Non-DGE 0.79 79.28147 509 NA NA NA Antimicrobial NA NA A0A1Y2V553; Uncharacterized protein; Hypoxylon sp. CO27-5; 4.332e-45 A0A6A6B2B8; Uncharacterized protein; Aplosporella prunicola CBS 121167; 2.514e-42
XANPAGTX0501_006270-T1 cl14 No annotation Non-DGE 0.57 55.33792 542 NA NA NA Below pLDDT threshold NA NA A0A5N6L017; Uncharacterized protein; Carpinus fangiana; 7.191e-07 A0A2B7X216; Uncharacterized protein; Polytolypa hystricis UAMH7299; 9.167e-07
XANPAGTX0501_000377-T1 cl15 No annotation Non-DGE 0.72 71.00979 284 NA NA NA Antimicrobial NA NA A0A6G1LIW3; Uncharacterized protein; Teratosphaeria nubilosa; 2.048e-06 X0BWY9; Uncharacterized protein; Fusarium oxysporum f. sp. raphani 54005; 2.597e-06
XANPAGTX0501_004983-T1 cl15 No annotation Upregulated in lichen 0.53 48.55580 305 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_005038-T1 cl15 No annotation Non-DGE 0.58 56.47559 535 NA NA NA Below pLDDT threshold NA NA T0KPG9; Uncharacterized protein; Colletotrichum gloeosporioides (strain Cg-14) (Anthracnose fungus) (Glomerella cingulata); 1.935e-12 A0A3M9XZ81; Uncharacterized protein; Verticillium nonalfalfae; 5.127e-11
XANPAGTX0501_005319-T1 cl15 No annotation Non-DGE 0.75 72.21204 506 NA NA NA Antimicrobial NA NA A0A0G4KS37; Uncharacterized protein; Verticillium longisporum; 3.838e-14 A0A4R8T4G7; Uncharacterized protein; Colletotrichum sidae; 8.489e-13
XANPAGTX0501_005320-T1 cl15 No annotation Non-DGE 0.64 63.34690 478 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_006348-T1 cl15 No annotation Non-DGE 0.58 61.99405 447 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_006926-T1 cl15 No annotation Upregulated in culture 0.71 71.66184 425 NA NA NA Antimicrobial NA NA NA NA
XANPAGTX0501_008429-T1 cl15 No annotation Upregulated in lichen 0.78 77.60765 243 NA NA NA Non-antimicrobial NA NA NA NA
XANPAGTX0501_000646-T1 cl16 Ribonuclease/ribotoxin Non-DGE 0.74 80.19038 182 IPR016191 Ribonuclease/ribotoxin NA NA Non-antimicrobial 1FUT; CRYSTAL STRUCTURES OF RIBONUCLEASE F1 OF FUSARIUM MONILIFORME IN ITS FREE FORM AND IN COMPLEX WITH 2’GMP; 1.408e-05 NA A0A0K8LLL5; deleted; ; 1.111e-06 A0A0K6G181; Uncharacterized protein; Rhizoctonia solani; 1.426e-06
XANPAGTX0501_007281-T1 cl16 Ribonuclease/ribotoxin Non-DGE 0.74 87.60496 139 IPR000026 Guanine-specific ribonuclease N1/T1/U2;IPR016191 Ribonuclease/ribotoxin NA NA Antimicrobial 1I3F; Ribonuclease T1 V89S mutant; 2.928e-15 1TRP; X-RAY CRYSTALLOGRAPHIC AND CALORIMERIC STUDIES OF THE EFFECTS OF THE MUTATION TRP 59 TYR IN RIBONUCLEASE T1; 6.326e-15 W9XZU6; ribonuclease T1 (EC 4.6.1.24); Capronia epimyces CBS 606.96; 6.062e-17 A0A1C1CET9; ribonuclease T1 (EC 4.6.1.24); Cladophialophora carrionii; 4.159e-16
XANPAGTX0501_002596-T1 cl17 Peptidase S53 Non-DGE 0.9 89.73216 619 IPR000209 Peptidase S8/S53 domain;IPR015366 Peptidase S53, activation domain;IPR023828 Peptidase S8, subtilisin, Ser-active site;IPR030400 Sedolisin domain;IPR036852 Peptidase S8/S53 domain superfamily NA S53 Non-antimicrobial 3EDY; Crystal Structure of the Precursor Form of Human Tripeptidyl-Peptidase 1; 4.498e-49 3EE6; Crystal Structure Analysis of Tripeptidyl peptidase -I; 9.796e-48 A0A6G1I2G3; tripeptidyl-peptidase II (EC 3.4.14.10); Trichodelitschia bisporula; 3.736e-78 A0A164QKC3; tripeptidyl-peptidase II (EC 3.4.14.10); Sistotremastrum niveocremeum HHB9708; 2.151e-73
XANPAGTX0501_003328-T1 cl17 Peptidase S53 Non-DGE 0.84 87.49923 612 IPR015366 Peptidase S53, activation domain;IPR030400 Sedolisin domain;IPR036852 Peptidase S8/S53 domain superfamily NA S53 Non-antimicrobial 3EDY; Crystal Structure of the Precursor Form of Human Tripeptidyl-Peptidase 1; 6.506e-53 3EE6; Crystal Structure Analysis of Tripeptidyl peptidase -I; 9.783e-52 A1D7F7; tripeptidyl-peptidase II (EC 3.4.14.10); Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus); 1.43e-76 A0A1V8T4J3; Peptidase S53 domain-containing protein; Rachicladosporium antarcticum; 4.12e-50
XANPAGTX0501_002543-T1 cl18 Match to effector from Zymoseptoria Upregulated in lichen 0.64 67.46685 200 NA NA NA Antimicrobial NA NA A0A5M8PQZ5; Uncharacterized protein; Lasallia pustulata; 2.679e-09 A0A5M8PHA6; Uncharacterized protein; Lasallia pustulata; 1.102e-08
XANPAGTX0501_002595-T1 cl18 Match to effector from Zymoseptoria Non-DGE 0.62 57.62480 229 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_003855-T1 cl18 Match to effector from Zymoseptoria Non-DGE 0.68 73.40631 195 NA NA NA Non-antimicrobial NA NA A0A5M8PQF4; Uncharacterized protein; Lasallia pustulata; 2.25e-07 A0A5M8PC24; Uncharacterized protein; Lasallia pustulata; 3.473e-05
XANPAGTX0501_004956-T1 cl18 Match to effector from Zymoseptoria Upregulated in lichen 0.62 61.62803 188 NA NA NA Below pLDDT threshold NA NA A0A5M8Q4D1; Uncharacterized protein; Lasallia pustulata; 0.0002609 A0A5M8Q1J0; Uncharacterized protein; Lasallia pustulata; 0.0007029
XANPAGTX0501_005641-T1 cl18 Match to effector from Zymoseptoria Upregulated in lichen 0.66 73.20612 209 NA NA NA Non-antimicrobial NA NA A0A1W5CSP5; Cytidine deaminase-like; Lasallia pustulata; 2.034e-06 A0A5M8PZ52; Uncharacterized protein; Lasallia pustulata; 1.171e-05
XANPAGTX0501_008683-T1 cl18 Match to effector from Zymoseptoria Upregulated in lichen 0.71 76.60421 209 NA NA NA Non-antimicrobial NA NA A0A1W5CSP5; Cytidine deaminase-like; Lasallia pustulata; 1.442e-08 A0A5M8PR05; Uncharacterized protein; Lasallia pustulata; 1.433e-07
XANPAGTX0501_000644-T1 cl19 No annotation Non-DGE 0.73 73.47119 236 NA NA NA Non-antimicrobial NA NA A0A364MAI2; Ecp2 effector protein domain-containing protein; Aspergillus flavus; 4.915e-08 A0A084FV09; Ecp2 effector protein domain-containing protein; Pseudallescheria apiosperma (Scedosporium apiospermum); 1.771e-07
XANPAGTX0501_007888-T1 cl19 No annotation Non-DGE 0.51 51.87602 166 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_007976-T1 cl19 No annotation Upregulated in lichen 0.54 55.04935 309 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_008764-T1 cl19 No annotation Non-DGE 0.64 62.55342 243 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_000439-T1 cl20 No annotation Non-DGE 0.63 67.11952 167 NA NA NA Antimicrobial NA NA A0A060SPR1; Uncharacterized protein; Pycnoporus cinnabarinus (Cinnabar-red polypore) (Trametes cinnabarina); 1.146e-06 NA
XANPAGTX0501_000698-T1 cl20 No annotation Non-DGE 0.54 55.60140 200 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_002722-T1 cl20 No annotation Non-DGE 0.54 63.87725 193 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_007377-T1 cl20 No annotation Non-DGE 0.61 59.38955 178 NA NA NA Below pLDDT threshold NA NA A0A060SPR1; Uncharacterized protein; Pycnoporus cinnabarinus (Cinnabar-red polypore) (Trametes cinnabarina); 9.237e-07 NA
XANPAGTX0501_008667-T1 cl20 No annotation Non-DGE 0.71 75.29108 166 NA NA NA Non-antimicrobial NA NA A0A094A1V4; Ecp2 effector protein domain-containing protein; Pseudogymnoascus sp. VKM F-4281 (FW-2241); 1.342e-10 B8M3Y5; Ecp2 effector protein domain-containing protein; Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006) (Penicillium stipitatum); 5.448e-10
XANPAGTX0501_010200-T1 cl20 No annotation Non-DGE 0.7 72.32185 173 NA NA NA Non-antimicrobial NA NA A0A094A1V4; Ecp2 effector protein domain-containing protein; Pseudogymnoascus sp. VKM F-4281 (FW-2241); 1.676e-10 B8M3Y5; Ecp2 effector protein domain-containing protein; Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006) (Penicillium stipitatum); 2.043e-07
XANPAGTX0501_010384-T1 cl20 No annotation Non-DGE 0.75 72.57189 344 NA NA NA Non-antimicrobial NA NA A0A5M8Q3Y7; Uncharacterized protein; Lasallia pustulata; 0.0006552 NA
XANPAGTX0501_000479-T1 cl21 Killer toxin Non-DGE 0.56 55.79035 202 IPR015131 Killer toxin, Kp4 NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_003600-T1 cl21 Killer toxin Non-DGE 0.82 90.35133 143 IPR011329 Killer toxin Kp4/SMK;IPR015131 Killer toxin, Kp4 NA NA Non-antimicrobial 1KPT; STRUCTURE AND FUNCTION OF A VIRALLY ENCODED FUNGAL TOXIN FROM USTILAGO MAYDIS: A FUNGAL AND MAMMALIAN CALCIUM CHANNEL INHIBITOR; 2.3e-09 NA A9TFY6; deleted; ; 5.422e-14 A0A1B8CHQ2; Killer toxin Kp4 domain-containing protein; Pseudogymnoascus sp. WSF 3629; 3.199e-13
XANPAGTX0501_003928-T1 cl21 Killer toxin Non-DGE 0.66 67.63112 188 IPR011329 Killer toxin Kp4/SMK;IPR015131 Killer toxin, Kp4 NA NA Non-antimicrobial NA NA F9F9K8; Killer toxin Kp4 domain-containing protein; Fusarium oxysporum (strain Fo5176) (Fusarium vascular wilt); 5.914e-07 A0A1B8CHQ2; Killer toxin Kp4 domain-containing protein; Pseudogymnoascus sp. WSF 3629; 7.571e-07
XANPAGTX0501_005492-T1 cl21 Killer toxin Non-DGE 0.68 68.89830 176 IPR011329 Killer toxin Kp4/SMK;IPR015131 Killer toxin, Kp4 NA NA Non-antimicrobial NA NA A0A6A5ZMZ9; Killer toxin Kp4/SMK; Lophiotrema nucula; 9.134e-06 NA
XANPAGTX0501_009135-T1 cl21 Killer toxin Upregulated in lichen 0.66 76.66139 187 IPR011329 Killer toxin Kp4/SMK;IPR015131 Killer toxin, Kp4 NA NA Non-antimicrobial NA NA A0A6A6ELN5; Killer toxin Kp4 domain-containing protein; Zopfia rhizophila CBS 207.26; 1.3e-06 A0A094D0J3; Killer toxin Kp4 domain-containing protein; Pseudogymnoascus sp. VKM F-4515 (FW-2607); 6.152e-06
XANPAGTX0501_003287-T1 cl22 No annotation Upregulated in lichen 0.73 80.95278 144 NA NA NA Non-antimicrobial NA NA A0A161W712; Uncharacterized protein; Colletotrichum tofieldiae; 3.962e-09 A0A167B5E5; Uncharacterized protein; Colletotrichum incanum; 2.258e-08
XANPAGTX0501_005361-T1 cl22 No annotation Upregulated in lichen 0.65 74.83741 116 NA NA NA Non-antimicrobial NA NA A0A0G2EKX1; Uncharacterized protein; Diplodia seriata; 5.77e-07 A0A6A6BTW9; Ecp2 effector protein domain-containing protein; Aplosporella prunicola CBS 121167; 2.452e-06
XANPAGTX0501_002191-T1 cl23 No annotation Upregulated in lichen 0.64 64.15772 197 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_007255-T1 cl23 No annotation Non-DGE 0.51 59.76941 387 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_010210-T1 cl23 No annotation Non-DGE 0.51 59.76941 387 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_000051-T1 cl24 Match to effector from Zymoseptoria Upregulated in lichen 0.72 74.54809 209 NA NA NA Antimicrobial NA NA A0A6A5VL10; Cyanovirin-N domain-containing protein; Bimuria novae-zelandiae CBS 107.79; 0.0006847 NA
XANPAGTX0501_000388-T1 cl24 Match to effector from Zymoseptoria Non-DGE 0.62 66.82851 181 NA NA NA Antimicrobial NA NA NA NA
XANPAGTX0501_000861-T1 cl24 Match to effector from Zymoseptoria Non-DGE 0.73 74.76842 196 NA NA NA Non-antimicrobial NA NA NA NA
XANPAGTX0501_001970-T1 cl24 Match to effector from Zymoseptoria Upregulated in lichen 0.74 78.09834 199 NA NA NA Non-antimicrobial NA NA A0A7U2HV09; Ecp2 effector protein domain-containing protein; Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Parastagonospora nodorum); 0.0003166 A0A132B635; Uncharacterized protein; Mollisia scopiformis (Conifer needle endophyte fungus) (Phialocephala scopiformis); 0.000469
XANPAGTX0501_003296-T1 cl24 Match to effector from Zymoseptoria Non-DGE 0.73 79.00464 209 NA NA NA Non-antimicrobial NA NA A0A3A2ZMW6; Ecp2 effector protein domain-containing protein; Aspergillus sclerotialis; 0.0007546 NA
XANPAGTX0501_005376-T1 cl24 Match to effector from Zymoseptoria Non-DGE 0.68 76.84675 191 NA NA NA Non-antimicrobial NA NA A0A1Y2W2A6; Ig-like domain-containing protein; Hypoxylon sp. CI-4A; 0.0001963 NA
XANPAGTX0501_006142-T1 cl24 Match to effector from Zymoseptoria Upregulated in lichen 0.68 72.71696 171 NA NA NA Non-antimicrobial NA NA NA NA
XANPAGTX0501_006349-T1 cl24 Match to effector from Zymoseptoria Upregulated in lichen 0.7 75.74075 226 NA NA NA Non-antimicrobial NA NA NA NA
XANPAGTX0501_007288-T1 cl24 Match to effector from Zymoseptoria Non-DGE 0.61 72.42179 319 IPR002889 Carbohydrate-binding WSC AA2, AA5 NA Antimicrobial 7PZ2; Structure of the mechanosensor domain of Wsc1 from Saccharomyces cerevisiae; 1.55e-07 6SNW; Structure of Coxsackievirus A10 complexed with its receptor KREMEN1; 4.531e-05 A0A1Y2LJZ5; WSC domain-containing protein; Epicoccum nigrum (Soil fungus) (Epicoccum purpurascens); 2.401e-08 D8LDH2; WSC domain-containing protein; Ectocarpus siliculosus (Brown alga) (Conferva siliculosa); 4.264e-08
XANPAGTX0501_000410-T1 cl24a Match to effector from Zymoseptoria Non-DGE 0.77 83.43706 293 NA NA NA Non-antimicrobial NA NA NA NA
XANPAGTX0501_002475-T1 cl24a Match to effector from Zymoseptoria Non-DGE 0.77 81.77143 286 NA NA NA Non-antimicrobial NA NA NA NA
XANPAGTX0501_005533-T1 cl24a Match to effector from Zymoseptoria Upregulated in lichen 0.74 79.01963 325 NA NA NA Non-antimicrobial NA NA NA NA
XANPAGTX0501_006379-T1 cl24a Match to effector from Zymoseptoria Non-DGE 0.69 74.20991 326 NA NA NA Non-antimicrobial NA NA NA NA
XANPAGTX0501_007272-T1 cl24a Match to effector from Zymoseptoria Upregulated in lichen 0.79 84.63390 287 NA NA NA Antimicrobial NA NA Q0UJL2; Ecp2 effector protein domain-containing protein; Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Parastagonospora nodorum); 0.0008085 A0A165A189; Ecp2 effector protein domain-containing protein; Xylona heveae (strain CBS 132557 / TC161); 0.0008581
XANPAGTX0501_008015-T1 cl24a Match to effector from Zymoseptoria Non-DGE 0.73 78.45364 324 NA NA NA Non-antimicrobial NA NA NA NA
XANPAGTX0501_009178-T1 cl24a Match to effector from Zymoseptoria Non-DGE 0.77 81.47093 302 NA NA NA Non-antimicrobial NA NA A0A175WEN3; Uncharacterized protein; Madurella mycetomatis; 0.0002072 A0A165A189; Ecp2 effector protein domain-containing protein; Xylona heveae (strain CBS 132557 / TC161); 0.0003844
XANPAGTX0501_009189-T1 cl24a Match to effector from Zymoseptoria Upregulated in lichen 0.65 67.62702 171 NA NA NA Non-antimicrobial NA NA NA NA
XANPAGTX0501_009340-T1 cl24a Match to effector from Zymoseptoria Upregulated in lichen 0.64 67.21936 266 NA NA NA Non-antimicrobial NA NA A0A6A5VL10; Cyanovirin-N domain-containing protein; Bimuria novae-zelandiae CBS 107.79; 0.0007672 NA
XANPAGTX0501_009690-T1 cl24a Match to effector from Zymoseptoria Upregulated in lichen 0.63 65.94845 328 NA NA NA Non-antimicrobial NA NA NA NA
XANPAGTX0501_010665-T1 cl24a Match to effector from Zymoseptoria Non-DGE 0.76 77.92679 296 NA NA NA Non-antimicrobial NA NA NA NA
XANPAGTX0501_003203-T1 cl25 Beta lactamase Non-DGE 0.9 89.68095 465 IPR001466 Beta-lactamase-related;IPR012338 Beta-lactamase/transpeptidase-like NA S12 Antimicrobial 4GDN; Structure of FmtA-like protein; 5.787e-15 4GDN; Structure of FmtA-like protein; 2.3e-14 A0A428PJV0; Beta-lactamase-related domain-containing protein; Fusarium duplospermum; 4.281e-48 A0A2V1BZZ6; Beta-lactamase/transpeptidase-like protein; Cadophora sp. DSE1049; 7.489e-37
XANPAGTX0501_008641-T1 cl25 Beta lactamase Non-DGE 0.9 90.17461 553 IPR001466 Beta-lactamase-related;IPR012338 Beta-lactamase/transpeptidase-like;IPR021860 Peptidase S12, Pab87-related, C-terminal NA S12 Antimicrobial 7SPN; Crystal structure of IS11, a thermophilic esterase; 2.129e-27 1PW8; Covalent Acyl Enzyme Complex Of The R61 DD-Peptidase with A Highly Specific Cephalosporin; 8.092e-20 A0A6A6W745; Beta-lactamase/transpeptidase-like protein; Pseudovirgaria hyperparasitica; 6.39e-64 A0A1W5CZ75; Peptidase S12, Pab87-related, C-terminal; Lasallia pustulata; 1.293e-63
XANPAGTX0501_000306-T1 cl26 DUF3455 Upregulated in culture 0.82 82.46790 276 IPR021851 Protein of unknown function DUF3455 NA NA Non-antimicrobial NA NA A0A1W5D603; Malate dehydrogenase; Lasallia pustulata; 7.134e-22 A0A6G1G1Q5; Malate dehydrogenase; Eremomyces bilateralis CBS 781.70; 1.618e-21
XANPAGTX0501_003469-T1 cl26 DUF3455 Non-DGE 0.79 86.94504 240 IPR021851 Protein of unknown function DUF3455 NA NA Antimicrobial NA NA A0A1W5CS07; Malate dehydrogenase; Lasallia pustulata; 1.979e-23 A0A2T6ZAT9; Uncharacterized protein; Tuber borchii (White truffle); 6.239e-18
XANPAGTX0501_005365-T1 cl27 Cetoacetate decarboxylase Non-DGE 0.85 85.17466 309 NA NA NA Non-antimicrobial NA NA U1HXP1; Uncharacterized protein; Endocarpon pusillum (strain Z07020 / HMAS-L-300199) (Lichen-forming fungus); 9.683e-33 A0A7C8JJ05; Uncharacterized protein; Orbilia oligospora (Nematode-trapping fungus) (Arthrobotrys oligospora); 2.491e-17
XANPAGTX0501_007902-T1 cl27 Cetoacetate decarboxylase Non-DGE 0.82 82.39059 323 NA NA NA Non-antimicrobial 3CMB; Crystal structure of acetoacetate decarboxylase (YP_001047042.1) from Methanoculleus marisnigri JR1 at 1.60 A resolution; 2.758e-05 NA A0A094IDM6; Peptidase A1 domain-containing protein; Pseudogymnoascus sp. VKM F-4520 (FW-2644); 5.761e-28 A0A093ZEF1; Acetoacetate decarboxylase; Pseudogymnoascus sp. VKM F-4246; 1.242e-26
XANPAGTX0501_005675-T1 cl28 Mettalopeptidase Upregulated in lichen 0.88 91.35971 280 IPR008754 Peptidase M43, pregnancy-associated plasma-A;IPR024079 Metallopeptidase, catalytic domain superfamily NA M43B Non-antimicrobial 7UFG; Cryo-EM structure of PAPP-A in complex with IGFBP5; 1.244e-09 7Y5N; Structure of 1:1 PAPP-A.ProMBP complex(half map); 4.116e-09 A0A2P8ADR0; Extracellular metalloprotease-4; Elsinoe australis; 6.434e-32 A0A0G2E8P6; Putative metalloprotease 1; Diplodia seriata; 5.14e-31
XANPAGTX0501_008269-T1 cl28 Mettalopeptidase Non-DGE 0.78 80.12037 300 IPR001506 Peptidase M12A;IPR006026 Peptidase, metallopeptidase;IPR024079 Metallopeptidase, catalytic domain superfamily NA M12A Non-antimicrobial 3EDG; Crystal structure of bone morphogenetic protein 1 protease domain; 3.559e-12 3VTG; High choriolytic enzyme 1 (HCE-1), a hatching enzyme zinc-protease from Oryzias latipes (Medaka fish); 4.882e-12 A0A6A5KBT9; Zincin; Decorospora gaudefroyi; 1.18e-18 A0A177D3J4; Peptidase metallopeptidase domain-containing protein; Alternaria alternata (Alternaria rot fungus) (Torula alternata); 1.426e-18
XANPAGTX0501_000709-T1 cl29 Extracellular membrane protein Non-DGE 0.57 66.07068 369 IPR008427 Extracellular membrane protein, CFEM domain NA NA Non-antimicrobial NA NA NA NA
XANPAGTX0501_007274-T1 cl29 Extracellular membrane protein Non-DGE 0.6 69.00925 268 NA NA NA Non-antimicrobial NA NA NA NA
XANPAGTX0501_009181-T1 cl29 Extracellular membrane protein Non-DGE 0.68 70.78173 260 IPR008427 Extracellular membrane protein, CFEM domain NA NA Non-antimicrobial NA NA NA NA
XANPAGTX0501_009311-T1 cl29 Extracellular membrane protein Upregulated in lichen 0.59 64.72571 287 IPR008427 Extracellular membrane protein, CFEM domain NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_000850-T1 cl30 No annotation Upregulated in culture 0.57 75.66208 192 NA NA NA Antimicrobial NA NA J3PGZ1; Uncharacterized protein; Gaeumannomyces tritici (strain R3-111a-1) (Wheat and barley take-all root rot fungus) (Gaeumannomyces graminis var. tritici); 0.0002212 A0A6G1ITF1; Carbohydrate-binding module family 18 protein; Lentithecium fluviatile CBS 122367; 0.0008497
XANPAGTX0501_003101-T1 cl30 No annotation Non-DGE 0.52 66.07706 126 NA NA NA Non-antimicrobial NA NA NA NA
XANPAGTX0501_007884-T1 cl30 No annotation Non-DGE 0.73 76.02150 917 IPR005151 Tail specific protease;IPR029045 ClpP/crotonase-like domain superfamily NA NA Non-antimicrobial 4QL6; Structure of C. trachomatis CT441; 7.683e-05 NA A0A7R7XK62; Tail specific protease domain-containing protein; Aspergillus puulaauensis; 3.654e-74 A0A6J3MGP7; Tail specific protease domain-containing protein; Dissoconium aciculare CBS 342.82; 2.506e-71
XANPAGTX0501_007275-T1 cl31 No annotation Non-DGE 0.76 88.21626 251 IPR009045 Hedgehog signalling/DD-peptidase zinc-binding domain superfamily GH24 NA Antimicrobial NA NA E5QZM3; D-alanyl-D-alanine carboxypeptidase; Arthroderma gypseum (strain ATCC MYA-4604 / CBS 118893) (Microsporum gypseum); 2.24e-33 J3KFN9; Secreted protein; Coccidioides immitis (strain RS) (Valley fever fungus); 1.87e-31
XANPAGTX0501_009038-T1 cl31 No annotation Non-DGE 0.58 72.22559 739 NA NA NA Antimicrobial NA NA A0A436ZYR3; Uncharacterized protein; Arthrobotrys flagrans; 2.304e-40 A0A6A6QP31; Uncharacterized protein; Lophium mytilinum; 1.441e-33
XANPAGTX0501_010470-T1 cl31 No annotation Upregulated in lichen 0.59 83.84567 268 IPR002196 Glycoside hydrolase, family 24;IPR023346 Lysozyme-like domain superfamily;IPR033907 Endolysin/autolysin;IPR034690 Endolysin T4 type GH24 NA Antimicrobial 6ET6; Crystal structure of muramidase from Acinetobacter baumannii AB 5075UW prophage; 6.681e-12 6H9D; Muramidase domain of SpmX from Asticaccaulis excentricus; 2.291e-11 A0A5N6J8L9; lysozyme (EC 3.2.1.17); Aspergillus minisclerotigenes; 1.735e-16 A0A8B6S7C1; deleted; ; 4.096e-10
XANPAGTX0501_010734-T1 cl31 No annotation Non-DGE 0.68 86.89559 254 IPR000064 Endopeptidase, NLPC/P60 domain;IPR038765 Papain-like cysteine peptidase superfamily NA C40 Antimicrobial 4HPE; Crystal structure of a putative cell wall hydrolase (CD630_03720) from Clostridium difficile 630 at 2.38 A resolution; 3.831e-08 6BIQ; Structure of NlpC2 from Trichomonas vaginalis; 1.965e-07 A0A0U1M172; NlpC/P60 domain-containing protein; Talaromyces islandicus (Penicillium islandicum); 1.076e-24 A0A397GAT8; NlpC/P60 domain-containing protein; Aspergillus thermomutatus; 2.113e-23
XANPAGTX0501_000452-T1 cl32 Mettalopeptidase Non-DGE 0.73 74.09979 289 NA NA NA Antimicrobial NA NA NA NA
XANPAGTX0501_001785-T1 cl32 Mettalopeptidase Non-DGE 0.71 82.63160 307 IPR024079 Metallopeptidase, catalytic domain superfamily;IPR029482 Putative peptidase domain, HRXXH NA NA Non-antimicrobial 2X3B; AsaP1 inactive mutant E294A, an extracellular toxic zinc metalloendopeptidase; 4.415e-06 2X3B; AsaP1 inactive mutant E294A, an extracellular toxic zinc metalloendopeptidase; 4.902e-06 A0A5N6TXD9; Putative peptidase domain-containing protein; Aspergillus avenaceus; 4.531e-30 A0A0D2G5Q1; Putative peptidase domain-containing protein; Rhinocladiella mackenziei CBS 650.93; 2.994e-28
XANPAGTX0501_002741-T1 cl32 Mettalopeptidase Non-DGE 0.69 70.91667 309 NA NA NA Non-antimicrobial NA NA Q0UCJ2; Neutral protease 2 homolog SNOG_10522 (EC 3.4.24.39) (Deuterolysin SNOG_10522); Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Parastagonospora nodorum); 3.274e-05 A0A3E2HK57; Uncharacterized protein; Scytalidium lignicola (Hyphomycete); 3.274e-05
XANPAGTX0501_002960-T1 cl32 Mettalopeptidase Non-DGE 0.73 74.64852 344 NA NA NA Antimicrobial NA NA G8S6Y6; Peptidyl-Lys metalloendopeptidase (EC 3.4.24.20); Actinoplanes sp. (strain ATCC 31044 / CBS 674.73 / SE50/110); 0.0001734 A0A820QVP5; Lysine-specific metallo-endopeptidase domain-containing protein; Rotaria sp. Silwood2; 0.0002052
XANPAGTX0501_004133-T1 cl32 Mettalopeptidase Non-DGE 0.78 80.51130 293 NA NA NA Non-antimicrobial NA NA A0A2C5YVE0; deuterolysin (EC 3.4.24.39); Ophiocordyceps australis; 0.0006721 NA
XANPAGTX0501_006381-T1 cl32 Mettalopeptidase Non-DGE 0.82 83.73197 300 IPR024079 Metallopeptidase, catalytic domain superfamily NA NA Non-antimicrobial NA NA A0A6A5YKP2; Lysine-specific metallo-endopeptidase domain-containing protein; Lophiotrema nucula; 3.617e-30 B2AKP7; Podospora anserina S mat+ genomic DNA chromosome 5, supercontig 9; Podospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) (Pleurage anserina); 3.832e-28
XANPAGTX0501_006429-T1 cl32 Mettalopeptidase Non-DGE 0.86 86.16997 308 NA NA NA Antimicrobial NA NA A0A6A6J4Z3; Lysine-specific metallo-endopeptidase domain-containing protein; Trematosphaeria pertusa; 2.553e-24 A0A2J6T3S3; Lysine-specific metallo-endopeptidase domain-containing protein; Hyaloscypha bicolor E; 4.036e-24
XANPAGTX0501_007985-T1 cl32 Mettalopeptidase Upregulated in culture 0.71 68.78266 320 NA NA NA Antimicrobial NA NA A0A7G5IQH8; Neutral protease 2 (EC 3.4.24.39) (Deuterolysin); Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167); 6.802e-05 A0A5N6WVU1; Neutral protease 2 (EC 3.4.24.39) (Deuterolysin); Aspergillus sergii; 0.0001065
XANPAGTX0501_009743-T1 cl32 Mettalopeptidase Non-DGE 0.68 65.87238 324 IPR024079 Metallopeptidase, catalytic domain superfamily NA NA Antimicrobial NA NA A0A7R7XV22; Lysine-specific metallo-endopeptidase domain-containing protein; Aspergillus puulaauensis; 4.849e-05 NA
XANPAGTX0501_009833-T1 cl32 Mettalopeptidase Non-DGE 0.84 82.80289 256 IPR024079 Metallopeptidase, catalytic domain superfamily NA NA Antimicrobial NA NA A0A151GRG3; deuterolysin (EC 3.4.24.39); Drechmeria coniospora; 3.762e-06 T5ACR4; deuterolysin (EC 3.4.24.39); Ophiocordyceps sinensis (strain Co18 / CGMCC 3.14243) (Yarsagumba caterpillar fungus) (Hirsutella sinensis); 1.02e-05
XANPAGTX0501_010126-T2 cl32 Mettalopeptidase Upregulated in culture 0.79 78.41123 285 NA NA NA Non-antimicrobial 1EB6; Deuterolysin from Aspergillus oryzae; 2.506e-06 NA A0A5N5DA29; Lysine-specific metallo-endopeptidase domain-containing protein; Lasiodiplodia theobromae; 2.919e-17 A0A4Q4TCS7; Lysine-specific metallo-endopeptidase domain-containing protein; Monosporascus sp. GIB2; 1.482e-15
XANPAGTX0501_010449-T1 cl32 Mettalopeptidase Upregulated in lichen 0.87 89.49591 357 IPR001384 Peptidase M35, deuterolysin;IPR024079 Metallopeptidase, catalytic domain superfamily;IPR029463 Lysine-specific metallo-endopeptidase NA M35 Non-antimicrobial 1EB6; Deuterolysin from Aspergillus oryzae; 3.4e-21 2X3B; AsaP1 inactive mutant E294A, an extracellular toxic zinc metalloendopeptidase; 3.408e-14 A0A4S9VFN0; Neutral protease 2 (EC 3.4.24.39) (Deuterolysin); Aureobasidium pullulans (Black yeast) (Pullularia pullulans); 2.265e-44 A0A1V1TI33; Neutral protease 2 (EC 3.4.24.39) (Deuterolysin); Xylariales sp. No.14919; 7.616e-37
XANPAGTX0501_002229-T1 cl33 Vacuolar protein sorting-associated protein 62 Non-DGE 0.86 89.77827 346 IPR009291 Vacuolar protein sorting-associated protein 62 NA NA Non-antimicrobial NA NA A0A5M8PH73; Vacuolar sorting-associated 62; Lasallia pustulata; 3.854e-49 A0A1W5D5Z6; Vacuolar protein sorting-associated protein 62; Lasallia pustulata; 1.931e-45
XANPAGTX0501_005009-T1 cl33 Vacuolar protein sorting-associated protein 62 Non-DGE 0.85 84.48363 386 IPR009291 Vacuolar protein sorting-associated protein 62 NA NA Non-antimicrobial NA NA A0A4V4I671; Vacuolar protein sorting-associated protein 62; Aureobasidium pullulans (Black yeast) (Pullularia pullulans); 1.132e-47 A0A6A6GR50; Vacuolar protein sorting-associated protein 62; Elsinoe ampelina; 1.649e-45
XANPAGTX0501_000719-T1 cl34 SnoaL Non-DGE 0.8 83.81541 329 NA NA NA Non-antimicrobial 7VX2; Crystal Structure of the Y53F/N55A/I80F/L114V/I116V mutant of LEH; 4.872e-06 4R9K; Structure of thermostable eightfold mutant of limonene epoxide hydrolase from Rhodococcus erythropolis; 2.03e-05 A0A6A6BEJ4; SnoaL-like domain-containing protein; Aplosporella prunicola CBS 121167; 1.804e-34 A0A6G1LCS3; Uncharacterized protein; Teratosphaeria nubilosa; 4.942e-33
XANPAGTX0501_001941-T1 cl34 SnoaL Non-DGE 0.85 90.60792 293 NA NA NA Non-antimicrobial 3D9R; Crystal structure of ketosteroid isomerase-like protein (YP_049581.1) from ERWINIA CAROTOVORA ATROSEPTICA SCRI1043 at 2.40 A resolution; 0.0004432 NA A0A139HMR0; Uncharacterized protein; Pseudocercospora eumusae; 7.208e-33 M3CZZ1; Uncharacterized protein; Sphaerulina musiva (strain SO2202) (Poplar stem canker fungus) (Septoria musiva); 4.734e-32
XANPAGTX0501_003378-T1 cl34 SnoaL Non-DGE 0.77 81.93318 192 IPR032710 NTF2-like domain superfamily;IPR037401 SnoaL-like domain NA NA Non-antimicrobial 4L8O; Crystal structure of a bile-acid 7-alpha dehydratase (CLOHYLEM_06634) from Clostridium hylemonae DSM 15053 at 2.20 A resolution; 2.427e-08 4STD; HIGH RESOLUTION STRUCTURES OF SCYTALONE DEHYDRATASE-INHIBITOR COMPLEXES CRYSTALLIZED AT PHYSIOLOGICAL PH; 9.329e-07 A0A2E9SS76; SnoaL-like domain-containing protein; Spongiibacter sp; 8.302e-09 A0A7H8RCZ4; SnoaL-like domain-containing protein; Talaromyces rugulosus; 9.321e-09
XANPAGTX0501_004515-T1 cl34 SnoaL Upregulated in lichen 0.76 84.68684 190 IPR032710 NTF2-like domain superfamily;IPR037401 SnoaL-like domain NA NA Non-antimicrobial 4LEH; Crystal structure of a bile-acid 7-alpha dehydratase (CLOSCI_03134) from Clostridium scindens ATCC 35704 at 2.90 A resolution; 2.685e-09 3S5C; Crystal Structure of a Hexachlorocyclohexane dehydrochlorinase (LinA) Type2; 7.372e-09 A0A0N1H2U8; SnoaL-like domain-containing protein; Phialophora attinorum; 1.719e-10 A0A364NA13; Ethyl tert-butyl ether degradation protein; Stemphylium lycopersici; 2.935e-10
XANPAGTX0501_002728-T1 cl35 Annotations do not match Non-DGE 0.72 76.14354 223 IPR010895 CHRD NA NA Non-antimicrobial NA NA A0A3M7JBK9; CHRD domain-containing protein; Hortaea werneckii; 2.265e-20 A0A5N6KY16; CHRD domain-containing protein; Carpinus fangiana; 6.646e-20
XANPAGTX0501_005716-T1 cl35 Annotations do not match Non-DGE 0.62 78.42504 272 IPR001424 Superoxide dismutase, copper/zinc binding domain;IPR036423 Superoxide dismutase-like, copper/zinc binding domain superfamily NA NA Non-antimicrobial 5CU9; CANDIDA ALBICANS SUPEROXIDE DISMUTASE 5 (SOD5), APO; 2.352e-15 5KBL; Candida Albicans Superoxide Dismutase 5 (SOD5), E110Q Mutant; 4.187e-15 A0A0J8TY34; Cytosolic Cu/Zn superoxide dismutase; Coccidioides immitis RMSCC 3703; 5.351e-21 H6BU51; Superoxide dismutase; Exophiala dermatitidis (strain ATCC 34100 / CBS 525.76 / NIH/UT8656) (Black yeast) (Wangiella dermatitidis); 5.351e-21
XANPAGTX0501_001455-T1 cl36 SUN family Upregulated in lichen 0.72 75.69017 461 IPR005556 SUN family GH132 NA Antimicrobial NA NA A0A093XL89; SUN domain-containing protein; Pseudogymnoascus sp. VKM F-3808; 1.105e-38 A0A094DHB8; SUN domain-containing protein; Pseudogymnoascus sp. VKM F-4516 (FW-969); 1.365e-38
XANPAGTX0501_007482-T1 cl36 SUN family Upregulated in culture 0.56 65.13208 534 IPR005556 SUN family GH132 NA Non-antimicrobial NA NA A0A370Q0T6; SUN-domain-containing protein; Aspergillus phoenicis ATCC 13157; 1.325e-47 A0A1L9UP51; SUN domain-containing protein; Aspergillus brasiliensis (strain CBS 101740 / IMI 381727 / IBT 21946); 3.928e-47
XANPAGTX0501_004065-T1 cl37 thaumatin-like Upregulated in lichen 0.55 65.60249 249 NA NA NA Antimicrobial NA NA NA NA
XANPAGTX0501_004980-T1 cl37 thaumatin-like Non-DGE 0.78 81.87807 238 NA NA NA Non-antimicrobial 3ZS3; High resolution structure of Mal d 2, the thaumatin like food allergen from apple; 2.839e-07 NA A0A1Y1HSG8; Pathogenesis-related thaumatin superfamily protein; Klebsormidium nitens (Green alga) (Ulothrix nitens); 1.569e-07 A0A4S8ZVY4; Uncharacterized protein; Aureobasidium pullulans (Black yeast) (Pullularia pullulans); 4.391e-07
XANPAGTX0501_000203-T1 cl38 thaumatin-like Non-DGE 0.79 80.85749 407 IPR001938 Thaumatin family;IPR037176 Osmotin/thaumatin-like superfamily GH152 NA Antimicrobial 1PCV; Crystal structure of osmotin, a plant antifungal protein; 1.711e-20 1AUN; PATHOGENESIS-RELATED PROTEIN 5D FROM NICOTIANA TABACUM; 3.375e-20 A0A0D2GDB4; Osmotin, thaumatin-like protein; Phialophora macrospora; 4.591e-50 U1GGB9; Peptidase A1 domain-containing protein; Endocarpon pusillum (strain Z07020 / HMAS-L-300199) (Lichen-forming fungus); 5.019e-48
XANPAGTX0501_001160-T1 cl38 thaumatin-like Non-DGE 0.53 59.19148 379 IPR037176 Osmotin/thaumatin-like superfamily NA NA Below pLDDT threshold 3ZS3; High resolution structure of Mal d 2, the thaumatin like food allergen from apple; 1.142e-06 7P23; Thaumatin-like protein of Puccinia graminis; 1.527e-06 A0A2V4ZJ14; deleted; ; 1.985e-09 F8C8J9; Lipoprotein; Myxococcus fulvus (strain ATCC BAA-855 / HW-1); 2.362e-09
XANPAGTX0501_001856-T1 cl38 thaumatin-like Upregulated in lichen 0.75 76.44470 279 IPR037176 Osmotin/thaumatin-like superfamily NA NA Antimicrobial 7P22; Thaumatin-like protein of Amycolatopsis rifamycinica; 1.236e-09 2AHN; High resolution structure of a cherry allergen Pru av 2; 3.103e-08 J3NYP6; Thaumatin family protein; Gaeumannomyces tritici (strain R3-111a-1) (Wheat and barley take-all root rot fungus) (Gaeumannomyces graminis var. tritici); 1.449e-23 A0A1L7XJV4; Uncharacterized protein; Phialocephala subalpina; 6.443e-23
XANPAGTX0501_006050-T1 cl38 thaumatin-like Non-DGE 0.78 82.52902 245 IPR037176 Osmotin/thaumatin-like superfamily NA NA Non-antimicrobial 3ZS3; High resolution structure of Mal d 2, the thaumatin like food allergen from apple; 1.157e-10 2AHN; High resolution structure of a cherry allergen Pru av 2; 1.128e-09 A0A0C3GRS3; Thaumatin-like protein; Oidiodendron maius (strain Zn); 1.089e-23 A0A1L7XJV4; Uncharacterized protein; Phialocephala subalpina; 5.673e-23
XANPAGTX0501_004102-T1 cl39 PIR domain Non-DGE 0.55 59.65142 295 IPR000420 Yeast PIR protein repeat NA NA Below pLDDT threshold NA NA A0A4U0Y4K5; Cell wall protein PhiA; Friedmanniomyces simplex; 2.054e-16 W2S867; Uncharacterized protein; Cyphellophora europaea CBS 101466; 5.37e-16
XANPAGTX0501_009124-T1 cl39 PIR domain Upregulated in culture 0.56 65.86180 272 NA NA NA Non-antimicrobial NA NA A0A0M8N8D4; Cell wall mannoprotein CIS3; Escovopsis weberi; 1.477e-11 A0A151GVE1; U1-C C2H2-type zinc finger domain-containing protein; Drechmeria coniospora; 3.936e-11
XANPAGTX0501_005564-T1 cl40 No annotation Non-DGE 0.83 89.79662 210 NA NA NA Non-antimicrobial NA NA A0A1F5L410; IgE-binding protein; Penicillium arizonense; 2.325e-16 A0A101MIG8; IgE-binding protein; Penicillium freii; 1.39e-15
XANPAGTX0501_008990-T1 cl40 No annotation Upregulated in lichen 0.72 76.45494 249 NA NA NA Antimicrobial NA NA A0A679NV77; deleted; ; 1.834e-09 A0A2J6PP26; WW domain-containing protein; Hyaloscypha hepaticicola; 3.444e-09
XANPAGTX0501_000656-T1 cl41 Ricin B-like lectin Upregulated in lichen 0.76 79.99352 196 IPR035992 Ricin B-like lectins NA NA Non-antimicrobial 8BAD; Tpp80Aa1; 3.84e-07 4I4Q; BEL beta-trefoil apo crystal form 3; 7.991e-06 A0A1Q3M7K9; Ricin B lectin domain-containing protein; Bacteroidales bacterium 45-6; 1.63e-09 A0A5M8P4M8; Ricin B lectin domain-containing protein; Candidatus Ordinivivax streblomastigis; 7.834e-09
XANPAGTX0501_006283-T1 cl41 Ricin B-like lectin Upregulated in lichen 0.53 56.14573 335 IPR035992 Ricin B-like lectins NA NA Below pLDDT threshold 3PG0; Crystal structure of designed 3-fold symmetric protein, ThreeFoil; 3.676e-08 7ZNX; Crystal structure of cocaprin 1, inhibitor of cysteine and aspartic proteases from Coprinopsis cinerea; 1.846e-07 A0A1L7XN80; Ricin B lectin domain-containing protein; Phialocephala subalpina; 1.391e-07 A0A229REW7; Ricin B lectin domain-containing protein; Amycolatopsis alba DSM 44262; 6.621e-07
XANPAGTX0501_010170-T1 cl41 Ricin B-like lectin Upregulated in lichen 0.75 79.09385 200 IPR035992 Ricin B-like lectins NA NA Non-antimicrobial 2X2S; Crystal structure of Sclerotinia sclerotiorum agglutinin SSA; 1.416e-10 6YH0; Marasmius oreades agglutinin (MOA) in complex with the truncated PVPRAHS synthetic substrate; 4.127e-09 A0A5M8P4M8; Ricin B lectin domain-containing protein; Candidatus Ordinivivax streblomastigis; 2.28e-10 A0A1Q3M7K9; Ricin B lectin domain-containing protein; Bacteroidales bacterium 45-6; 1.077e-09
XANPAGTX0501_009887-T1 cl42 Match to Trichoderma effector Upregulated in lichen 0.77 88.68807 145 NA NA NA Non-antimicrobial 7CWJ; Root induced Secreted protein Tsp1 from Biocontrol fungi Trichoderma virens; 1.474e-12 NA A0A6A6PH20; Small secreted protein; Neohortaea acidophila; 2.751e-14 R8B8V1; Putative small secreted protein; Phaeoacremonium minimum (strain UCR-PA7) (Esca disease fungus) (Togninia minima); 3.369e-13
XANPAGTX0501_005096-T1 cl43 GH43 Non-DGE 0.91 94.66982 325 IPR006710 Glycoside hydrolase, family 43;IPR016840 Glycoside hydrolase, family 43, endo-1, 5-alpha-L-arabinosidase;IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain superfamily GH43 NA Antimicrobial 1UV4; Native Bacillus subtilis Arabinanase Arb43A; 1.013e-22 6B7K; GH43 Endo-Arabinanase from Bacillus licheniformis; 1.088e-21 A0A4S9FM27; Arabinan endo-1,5-alpha-L-arabinosidase (EC 3.2.1.99); Aureobasidium pullulans (Black yeast) (Pullularia pullulans); 1.658e-39 C6HSE3; Arabinan endo-1,5-alpha-L-arabinosidase (EC 3.2.1.99); Ajellomyces capsulatus (strain H143) (Darling’s disease fungus) (Histoplasma capsulatum); 1.135e-36
XANPAGTX0501_010132-T1 cl43 GH43 Upregulated in culture 0.89 93.56190 331 IPR006710 Glycoside hydrolase, family 43;IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain superfamily GH43 NA Non-antimicrobial 4QQS; Crystal structure of a thermostable family-43 glycoside hydrolase; 4.459e-20 3QZ4; Crystal structure of an Endo-1,4-beta-xylanase D (BT_3675) from Bacteroides thetaiotaomicron VPI-5482 at 1.74 A resolution; 2.127e-18 A0A178BRK4; deleted; ; 5.515e-37 A0A0D2GG01; Glycoside hydrolase family 43 protein; Fonsecaea pedrosoi CBS 271.37; 2.227e-36
XANPAGTX0501_004076-T1 cl44 Six-bladed beta-propeller, TolB-like Non-DGE 0.91 93.69540 415 IPR011042 Six-bladed beta-propeller, TolB-like;IPR017996 Major royal jelly protein/protein yellow NA NA Non-antimicrobial 2QE8; Crystal structure of a putative hydrolase (ava_4197) from anabaena variabilis atcc 29413 at 1.35 A resolution; 2.27e-25 5I5M; Shewanella denitrificans nitrous oxide reductase, Ca2+-reconstituted form; 5.254e-08 A0A4U0XN52; Yippee domain-containing protein; Friedmanniomyces simplex; 1.999e-61 A0A074X049; Major royal jelly protein; Aureobasidium melanogenum CBS 110374; 6.732e-60
XANPAGTX0501_009462-T1 cl44 Six-bladed beta-propeller, TolB-like Non-DGE 0.83 86.40844 482 IPR011041 Soluble quinoprotein glucose/sorbosone dehydrogenase;IPR011042 Six-bladed beta-propeller, TolB-like AA12 NA Non-antimicrobial 6I1Q; Iodide structure of Trichoderma reesei Carbohydrate-Active Enzymes Family AA12; 1.964e-55 6I1T; Calcium structure of Trichoderma reesei Carbohydrate-Active Enzymes Family AA12; 6.186e-55 A0A6A6Y8K3; Soluble quino protein glucose dehydrogenase; Mytilinidion resinicola; 2.263e-64 R7YHI9; Glucose/Sorbosone dehydrogenase domain-containing protein; Coniosporium apollinis (strain CBS 100218) (Rock-inhabiting black yeast); 9.216e-62
XANPAGTX0501_002723-T1 cl45 Arylsulfotransferase-like Upregulated in culture 0.86 86.38564 548 IPR039535 Arylsulfotransferase-like NA NA Antimicrobial NA NA A0A4U0V102; ASST-domain-containing protein; Friedmanniomyces endolithicus; 2.083e-47 A0A6G1KWJ1; ASST-domain-containing protein; Teratosphaeria nubilosa; 1.765e-45
XANPAGTX0501_005133-T1 cl45 Arylsulfotransferase-like Upregulated in lichen 0.89 90.85668 394 IPR039535 Arylsulfotransferase-like NA NA Non-antimicrobial 2DSO; Crystal structure of D138N mutant of Drp35, a 35kDa drug responsive protein from Staphylococcus aureus; 0.0006019 NA A0A6A6Z1L7; ASST-domain-containing protein; Mytilinidion resinicola; 2.017e-37 A0A3M0VWU9; ASST-domain-containing protein; Chaetothyriales sp. CBS 134920; 1.006e-36
XANPAGTX0501_004346-T1 cl46 Annotations do not match Upregulated in lichen 0.92 94.10081 445 IPR027589 Choice-of-anchor B domain NA NA Non-antimicrobial 3F3P; Crystal structure of the nucleoporin pair Nup85-Seh1, space group P21212; 1.951e-06 3F3F; Crystal structure of the nucleoporin pair Nup85-Seh1, space group P21; 1.039e-05 A0A094EZH8; Regulatory P domain-containing protein; Pseudogymnoascus sp. VKM F-4518 (FW-2643); 1.181e-71 A0A094H9D5; Phospholipase/carboxylesterase/thioesterase domain-containing protein; Pseudogymnoascus sp. VKM F-4519 (FW-2642); 2.142e-70
XANPAGTX0501_007937-T1 cl46 Annotations do not match Upregulated in culture 0.89 91.92003 398 IPR011044 Quinoprotein amine dehydrogenase, beta chain-like;IPR015943 WD40/YVTN repeat-like-containing domain superfamily NA NA Antimicrobial 5B4X; Crystal structure of the ApoER2 ectodomain in complex with the Reelin R56 fragment; 6.968e-07 3P5B; The structure of the LDLR/PCSK9 complex reveals the receptor in an extended conformation; 4.433e-06 S8BLJ6; SMP-30/Gluconolactonase/LRE-like region domain-containing protein; Dactylellina haptotyla (strain CBS 200.50) (Nematode-trapping fungus) (Monacrosporium haptotylum); 4.073e-38 A0A136IT31; 3-carboxymuconate cyclase; Microdochium bolleyi; 1.672e-37
XANPAGTX0501_010580-T1 cl46 Annotations do not match Upregulated in lichen 0.9 91.04026 427 IPR011048 Cytochrome cd1-nitrite reductase-like, haem d1 domain superfamily;IPR015943 WD40/YVTN repeat-like-containing domain superfamily;IPR019405 Lactonase, 7-bladed beta propeller NA NA Antimicrobial 3FGB; Crystal structure of the Q89ZH8_BACTN protein from Bacteroides thetaiotaomicron. Northeast Structural Genomics Consortium target BtR289b.; 9.951e-19 3SCY; Crystal structure of a putative 6-phosphogluconolactonase (BF1038) from Bacteroides fragilis NCTC 9343 at 1.50 A resolution; 1.206e-18 A0A2V1E0R6; Putative isomerase YbhE; Periconia macrospinosa; 3.423e-30 S3DGB5; Nitrous oxide reductase, N-terminal; Glarea lozoyensis (strain ATCC 20868 / MF5171); 2.445e-29
XANPAGTX0501_002120-T1 cl47 Germins cupins Non-DGE 0.68 78.28887 291 IPR001929 Germin;IPR006045 Cupin 1;IPR011051 RmlC-like cupin domain superfamily;IPR014710 RmlC-like jelly roll fold;IPR019780 Germin, manganese binding site NA NA Non-antimicrobial 6ORM; Crystal Structure of Peruvianin-I (Cysteine peptidase from Thevetia peruviana latex); 1e-12 2D5H; Crystal Structure of Recombinant Soybean Proglycinin A3B4 subunit, its Comparison with Mature Glycinin A3B4 subunit, Responsible for Hexamer Assembly; 6.395e-11 A0A3M6X7P0; Cupin type-1 domain-containing protein; Hortaea werneckii; 6.228e-33 A0A6A6TUZ1; Spherulin-1A; Microthyrium microscopicum; 9.708e-31
XANPAGTX0501_004938-T1 cl47 Germins cupins Non-DGE 0.87 92.12722 418 IPR006045 Cupin 1;IPR011051 RmlC-like cupin domain superfamily;IPR014710 RmlC-like jelly roll fold;IPR017774 Bicupin, oxalate decarboxylase/oxidase NA NA Non-antimicrobial 1L3J; Crystal Structure of Oxalate Decarboxylase Formate Complex; 9.185e-51 2UY9; E162A mutant of Bacillus subtilis Oxalate Decarboxylase OxdC; 1.793e-50 A0A3M7N675; Cupin type-1 domain-containing protein; Chaetothyriales sp. CBS 135597; 1.726e-62 V9DGY0; Cupin type-1 domain-containing protein; Cladophialophora carrionii CBS 160.54; 3.916e-61
XANPAGTX0501_005784-T1 cl48 No annotation Non-DGE 0.78 88.24251 187 NA NA NA Antimicrobial NA NA U1GM31; Small secreted protein; Endocarpon pusillum (strain Z07020 / HMAS-L-300199) (Lichen-forming fungus); 1.646e-20 A0A165BYR1; Small secreted protein; Exidia glandulosa HHB12029; 2.307e-18
XANPAGTX0501_007256-T1 cl48 No annotation Non-DGE 0.82 91.39403 176 NA NA NA Non-antimicrobial NA NA A0A177CNP0; Uncharacterized protein; Paraphaeosphaeria sporulosa; 5.474e-19 A0A1Y2E8A8; Small secreted protein; Pseudomassariella vexata; 1.785e-18
XANPAGTX0501_010209-T1 cl48 No annotation Non-DGE 0.82 91.39403 176 NA NA NA Non-antimicrobial NA NA A0A177CNP0; Uncharacterized protein; Paraphaeosphaeria sporulosa; 5.474e-19 A0A1Y2E8A8; Small secreted protein; Pseudomassariella vexata; 1.785e-18
XANPAGTX0501_000458-T1 cl49 GH16 Non-DGE 0.71 78.33200 400 IPR000757 Glycoside hydrolase family 16;IPR013320 Concanavalin A-like lectin/glucanase domain superfamily GH16 NA Non-antimicrobial 3WDV; The complex structure of PtLic16A with cellotetraose; 5.664e-38 3WDW; The apo-form structure of E113A from Paecilomyces thermophila; 9.174e-37 A0A0D1ZG35; GH16 domain-containing protein; Exophiala mesophila (Black yeast); 2.958e-40 A0A3M7MV44; GH16 domain-containing protein; Chaetothyriales sp. CBS 132003; 4.368e-40
XANPAGTX0501_000471-T1 cl49 GH16 Non-DGE 0.82 84.78436 376 IPR000757 Glycoside hydrolase family 16;IPR013320 Concanavalin A-like lectin/glucanase domain superfamily GH16 NA Antimicrobial 1U0A; Crystal structure of the engineered beta-1,3-1,4-endoglucanase H(A16-M) in complex with beta-glucan tetrasaccharide; 3.812e-14 1GLH; CATION BINDING TO A BACILLUS (1,3-1,4)-BETA-GLUCANASE. GEOMETRY, AFFINITY AND EFFECT ON PROTEIN STABILITY; 9.243e-14 A0A6A6B611; Glycoside hydrolase family 16 protein; Aplosporella prunicola CBS 121167; 4.021e-41 A0A4Q4MZN5; GH16 domain-containing protein; Alternaria alternata (Alternaria rot fungus) (Torula alternata); 1.518e-40
XANPAGTX0501_001066-T1 cl49 GH16 Non-DGE 0.66 74.05068 444 IPR000757 Glycoside hydrolase family 16;IPR013320 Concanavalin A-like lectin/glucanase domain superfamily GH16 NA Antimicrobial 3WDW; The apo-form structure of E113A from Paecilomyces thermophila; 2.475e-36 3WDV; The complex structure of PtLic16A with cellotetraose; 8.828e-36 A0A0D2CUR1; GH16 domain-containing protein; Exophiala xenobiotica; 3.298e-38 A0A6G0UNG1; GH16 domain-containing protein; Halicephalobus sp. NKZ332; 6.766e-38
XANPAGTX0501_001263-T1 cl49 GH16 Non-DGE 0.8 82.89324 364 IPR000757 Glycoside hydrolase family 16;IPR013320 Concanavalin A-like lectin/glucanase domain superfamily GH16 NA Non-antimicrobial 1U0A; Crystal structure of the engineered beta-1,3-1,4-endoglucanase H(A16-M) in complex with beta-glucan tetrasaccharide; 1.155e-11 1GBG; BACILLUS LICHENIFORMIS BETA-GLUCANASE; 1.996e-11 A0A6A6V9K5; Glycoside hydrolase family 16 protein; Sporormia fimetaria CBS 119925; 6.502e-34 A0A1L9Q3G8; GH16 domain-containing protein; Aspergillus versicolor CBS 583.65; 2.168e-33
XANPAGTX0501_004812-T1 cl49 GH16 Non-DGE 0.61 66.67060 464 IPR000757 Glycoside hydrolase family 16;IPR013320 Concanavalin A-like lectin/glucanase domain superfamily GH16 NA Non-antimicrobial 6IBW; Crh5 transglycosylase in complex with NAG; 1.481e-28 6IBW; Crh5 transglycosylase in complex with NAG; 3.832e-28 A0A4U0WMI9; GH16 domain-containing protein; Cryomyces minteri; 4.233e-39 A0A1X7RWD6; GH16 domain-containing protein; Zymoseptoria tritici ST99CH_3D7; 5.176e-37
XANPAGTX0501_005822-T1 cl49 GH16 Non-DGE 0.77 80.21573 454 IPR000757 Glycoside hydrolase family 16;IPR013320 Concanavalin A-like lectin/glucanase domain superfamily;IPR017168 Glycoside hydrolase, family 16, CRH1, predicted;IPR018371 Chitin-binding, type 1, conserved site GH16 NA Antimicrobial 6IBW; Crh5 transglycosylase in complex with NAG; 2.336e-20 6IBU; Apo Crh5 transglycosylase; 6.365e-20 A0A3M2SVX8; Glycosidase (EC 3.2.-.-); Aspergillus sp. HF37; 4.506e-46 A0A167FBP7; Glycosidase (EC 3.2.-.-); Sugiyamaella lignohabitans; 2.983e-42
XANPAGTX0501_009699-T1 cl49 GH16 Upregulated in lichen 0.64 77.79897 513 IPR000757 Glycoside hydrolase family 16;IPR001002 Chitin-binding, type 1;IPR008264 Beta-glucanase;IPR013320 Concanavalin A-like lectin/glucanase domain superfamily;IPR036861 Endochitinase-like superfamily GH16 NA Antimicrobial 1U0A; Crystal structure of the engineered beta-1,3-1,4-endoglucanase H(A16-M) in complex with beta-glucan tetrasaccharide; 8.474e-16 1GLH; CATION BINDING TO A BACILLUS (1,3-1,4)-BETA-GLUCANASE. GEOMETRY, AFFINITY AND EFFECT ON PROTEIN STABILITY; 4.226e-15 M3C4X1; Glycoside hydrolase family 16 protein; Sphaerulina musiva (strain SO2202) (Poplar stem canker fungus) (Septoria musiva); 3.925e-31 A0A1V8TT27; GH16 domain-containing protein; Rachicladosporium antarcticum; 9.526e-31
XANPAGTX0501_010345-T1 cl49 GH16 Non-DGE 0.82 86.19722 263 IPR000757 Glycoside hydrolase family 16;IPR013320 Concanavalin A-like lectin/glucanase domain superfamily GH16 NA Non-antimicrobial 1GBG; BACILLUS LICHENIFORMIS BETA-GLUCANASE; 2.032e-11 1U0A; Crystal structure of the engineered beta-1,3-1,4-endoglucanase H(A16-M) in complex with beta-glucan tetrasaccharide; 4.443e-11 M3B913; Glycoside hydrolase family 16 protein; Pseudocercospora fijiensis (strain CIRAD86) (Black leaf streak disease fungus) (Mycosphaerella fijiensis); 2.356e-19 A0A1V8TT27; GH16 domain-containing protein; Rachicladosporium antarcticum; 8.68e-19
XANPAGTX0501_005095-T1 cl50 GH12 Non-DGE 0.85 90.88338 269 IPR002594 Glycoside hydrolase family 12;IPR013319 Glycoside hydrolase family 11/12;IPR013320 Concanavalin A-like lectin/glucanase domain superfamily GH12 NA Antimicrobial 4H7M; The X-ray Crystal Structure of the Trichoderma harzianum Endoglucanase 3 from family GH12; 2.235e-18 1OA2; Comparison of Family 12 Glycoside Hydrolases and Recruited Substitutions Important for Thermal Stability; 3.044e-18 A0A1L7WVT4; Related to endoglucanase I; Phialocephala subalpina; 5.356e-37 A0A318ZLM3; xyloglucan-specific endo-beta-1,4-glucanase (EC 3.2.1.151) (Xyloglucanase A) (Xyloglucanendohydrolase A); Aspergillus saccharolyticus JOP 1030-1; 3.788e-36
XANPAGTX0501_005389-T1 cl50 GH12 Non-DGE 0.86 91.83622 249 IPR002594 Glycoside hydrolase family 12;IPR013319 Glycoside hydrolase family 11/12;IPR013320 Concanavalin A-like lectin/glucanase domain superfamily GH12 NA Antimicrobial 3VLB; Crystal structure of xeg-edgp; 9.282e-29 4NPR; Crystal Structure of the Family 12 Xyloglucanase from Aspergillus niveus; 1.27e-28 A0A4Q4RW40; Xyloglucan-specific endo-beta-1,4-glucanase A; Alternaria arborescens; 2.502e-33 A0A7U2EXK0; Uncharacterized protein; Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Parastagonospora nodorum); 1.885e-26
XANPAGTX0501_005664-T1 cl51 Galactose-binding domain Upregulated in culture 0.52 63.25380 276 NA GH128 NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_006702-T1 cl51 Galactose-binding domain Non-DGE 0.55 66.47848 297 IPR008979 Galactose-binding-like domain superfamily NA NA Antimicrobial 5W6H; Crystal structure of Bacteriophage CBA120 tailspike protein 4 enzymatically active domain (TSP4dN, orf213); 1.397e-07 2XOM; Atomic resolution structure of TmCBM61 in complex with beta-1,4- galactotriose; 1.331e-06 W0J3J6; Carbohydrate-binding protein CenC; Opitutaceae bacterium TAV5; 1.779e-07 A0A1V8TMC2; Uncharacterized protein; Rachicladosporium sp. CCFEE 5018; 2.954e-07
XANPAGTX0501_006869-T1 cl51 Galactose-binding domain Upregulated in culture 0.63 77.22822 270 IPR008979 Galactose-binding-like domain superfamily GH128 NA Antimicrobial 4D0Q; Hyaluronan Binding Module of the Streptococcal Pneumoniae Hyaluronate Lyase; 5.281e-08 5X7S; Crystal structure of Paenibacillus sp. 598K alpha-1,6-glucosyltransferase, terbium derivative; 5.515e-06 L2G4D3; Uncharacterized protein; Colletotrichum fructicola (strain Nara gc5) (Anthracnose fungus) (Colletotrichum gloeosporioides (strain Nara gc5)); 2.695e-19 A0A1V1TIS2; CBM-cenC domain-containing protein; Xylariales sp. No.14919; 3.906e-16
XANPAGTX0501_007616-T1 cl51 Galactose-binding domain Non-DGE 0.59 68.60583 290 IPR008979 Galactose-binding-like domain superfamily NA NA Non-antimicrobial 2Y6H; X-2 L110F CBM4-2 Carbohydrate Binding Module from a Thermostable Rhodothermus marinus Xylanase; 3.124e-09 3OEB; Crystal structure of the Q121E mutant of C.polysaccharolyticus CBM16-1 bound to mannopentaose; 1.295e-07 A0A5R9GPG3; Dockerin domain-containing protein; Paenibacillus antri; 1.147e-08 A0A0N8H727; Uncharacterized protein; Neonectria ditissima; 1.072e-07
XANPAGTX0501_008830-T1 cl51 Galactose-binding domain Non-DGE 0.54 68.70455 299 IPR008979 Galactose-binding-like domain superfamily NA NA Antimicrobial 8HHV; endo-alpha-D-arabinanase EndoMA1 from Microbacterium arabinogalactanolyticum; 3.315e-08 8IC1; endo-alpha-D-arabinanase EndoMA1 D51N mutant from Microbacterium arabinogalactanolyticum in complex with arabinooligosaccharides; 3.722e-08 A0A1W9VTK2; Peptidase M14 carboxypeptidase A domain-containing protein; Candidatus Cloacimonetes bacterium 4572_65; 1.961e-06 A0A4R6MXZ4; deleted; ; 4.949e-06
XANPAGTX0501_009317-T1 cl51 Galactose-binding domain Upregulated in lichen 0.58 66.13799 294 IPR008979 Galactose-binding-like domain superfamily NA NA Non-antimicrobial 2XOM; Atomic resolution structure of TmCBM61 in complex with beta-1,4- galactotriose; 1.095e-08 5X7S; Crystal structure of Paenibacillus sp. 598K alpha-1,6-glucosyltransferase, terbium derivative; 3.285e-05 A0A5J5ERX4; CBM-cenC domain-containing protein; Sphaerosporella brunnea; 3.593e-11 A0A6A6YR49; Apple domain-containing protein; Mytilinidion resinicola; 2.892e-07
XANPAGTX0501_010474-T1 cl51 Galactose-binding domain Upregulated in culture 0.79 84.95214 201 IPR008979 Galactose-binding-like domain superfamily NA NA Non-antimicrobial 2ZEZ; Family 16 Carbohydrate Binding Module-2; 4.183e-06 2WZE; High resolution crystallographic structure of the Clostridium thermocellum N-terminal endo-1,4-beta-D-xylanase 10B (Xyn10B) CBM22-1- GH10 modules complexed with xylohexaose; 0.0001278 A0A3M1RXR0; Choice-of-anchor C family protein; Gammaproteobacteria bacterium; 4.499e-07 A0A7S6M730; Tail specific protease domain-containing protein; Planctomycetia bacterium; 6.139e-07
XANPAGTX0501_010647-T1 cl51 Galactose-binding domain Non-DGE 0.63 72.54673 260 IPR008979 Galactose-binding-like domain superfamily GH128 NA Antimicrobial 5W6H; Crystal structure of Bacteriophage CBA120 tailspike protein 4 enzymatically active domain (TSP4dN, orf213); 2.615e-08 4D0Q; Hyaluronan Binding Module of the Streptococcal Pneumoniae Hyaluronate Lyase; 5.658e-08 A0A7C8GXG9; deleted; ; 4.344e-09 A0A2T5M4Z2; CBM-cenC domain-containing protein; Aspergillus ochraceoroseus IBT 24754; 1.342e-08
XANPAGTX0501_001631-T1 cl52 No annotation Non-DGE 0.78 83.01637 226 NA NA NA Non-antimicrobial NA NA A0A5M8PD82; Uncharacterized protein; Lasallia pustulata; 1.707e-19 A0A1C1CJ21; Secreted protein; Cladophialophora carrionii; 1.088e-16
XANPAGTX0501_006271-T1 cl52 No annotation Non-DGE 0.74 72.47268 224 NA NA NA Non-antimicrobial NA NA W3WJ19; Uncharacterized protein; Pestalotiopsis fici (strain W106-1 / CGMCC3.15140); 1.207e-11 W3WUU5; Ubiquitin 3 binding protein But2 C-terminal domain-containing protein; Pestalotiopsis fici (strain W106-1 / CGMCC3.15140); 2.754e-10
XANPAGTX0501_006292-T1 cl52 No annotation Upregulated in lichen 0.78 81.49940 215 NA NA NA Non-antimicrobial NA NA A0A2D3UQP5; Uncharacterized protein; Ramularia collo-cygni; 3.639e-12 G1XUG8; Uncharacterized protein; Arthrobotrys oligospora (strain ATCC 24927 / CBS 115.81 / DSM 1491) (Nematode-trapping fungus) (Didymozoophaga oligospora); 3.254e-11
XANPAGTX0501_010443-T1 cl52 No annotation Upregulated in lichen 0.78 81.49940 215 NA NA NA Non-antimicrobial NA NA A0A2D3UQP5; Uncharacterized protein; Ramularia collo-cygni; 3.639e-12 G1XUG8; Uncharacterized protein; Arthrobotrys oligospora (strain ATCC 24927 / CBS 115.81 / DSM 1491) (Nematode-trapping fungus) (Didymozoophaga oligospora); 3.254e-11
XANPAGTX0501_010550-T1 cl52 No annotation Non-DGE 0.76 76.22018 221 NA NA NA Non-antimicrobial NA NA A0A6H0XPF1; Uncharacterized protein; Peltaster fructicola; 2.477e-13 W3WJ19; Uncharacterized protein; Pestalotiopsis fici (strain W106-1 / CGMCC3.15140); 2.946e-12
XANPAGTX0501_005696-T1 cl53 Galactose-binding domain Coagulation factor. different otherwise Non-DGE 0.58 66.59997 308 IPR000421 Coagulation factor 5/8 C-terminal domain;IPR008979 Galactose-binding-like domain superfamily AA5, CBM32 NA Non-antimicrobial 2VZ3; bleached galactose oxidase; 3.085e-16 2EIB; Crystal Structure of Galactose Oxidase, W290H mutant; 4.113e-16 W3WLU1; F5/8 type C domain-containing protein; Pestalotiopsis fici (strain W106-1 / CGMCC3.15140); 2.397e-14 A0A2R4TD26; Arabinogalactan endo-1,4-beta-galactosidase; Streptomyces lunaelactis; 3.01e-13
XANPAGTX0501_007182-T1 cl53 Galactose-binding domain Coagulation factor. different otherwise Upregulated in culture 0.91 91.41861 1042 IPR005195 Glycoside hydrolase, family 65, central catalytic;IPR005196 Glycoside hydrolase, family 65, N-terminal;IPR008928 Six-hairpin glycosidase superfamily;IPR008979 Galactose-binding-like domain superfamily;IPR011013 Galactose mutarotase-like domain superfamily;IPR012341 Six-hairpin glycosidase-like superfamily;IPR037018 Glycoside hydrolase family 65, N-terminal domain superfamily NA NA Antimicrobial 7FE3; Crystal structure of GH65 alpha-1,2-glucosidase from Flavobacterium johnsoniae; 8.632e-41 6W0P; Putative kojibiose phosphorylase from human microbiome; 1.749e-38 A0A0D2H2P1; alpha,alpha-trehalase (EC 3.2.1.28); Fonsecaea pedrosoi CBS 271.37; 0 A0A3A2ZJN6; alpha,alpha-trehalase (EC 3.2.1.28); Aspergillus sclerotialis; 0
XANPAGTX0501_008294-T1 cl53 Galactose-binding domain Coagulation factor. different otherwise Upregulated in culture 0.94 95.20532 643 IPR000421 Coagulation factor 5/8 C-terminal domain;IPR006652 Kelch repeat type 1;IPR008979 Galactose-binding-like domain superfamily;IPR011043 Galactose oxidase/kelch, beta-propeller;IPR013783 Immunoglobulin-like fold;IPR014756 Immunoglobulin E-set;IPR015202 Galactose oxidase-like, Early set domain;IPR037293 Galactose oxidase, central domain superfamily AA5, CBM32 NA Non-antimicrobial 1T2X; Glactose oxidase C383S mutant identified by directed evolution; 3.095e-87 6XLS; The 1.80 Angstrom crystal structure of galactose oxidase variant with genetically incorporated F2-Tyr272; 5.263e-87 A0A7C8KZS6; deleted; ; 2.95e-61 A0A2T2N4Y8; Galactose oxidase; Corynespora cassiicola Philippines; 8.129e-61
XANPAGTX0501_009936-T1 cl53 Galactose-binding domain Coagulation factor. different otherwise Upregulated in lichen 0.79 86.94823 972 IPR000421 Coagulation factor 5/8 C-terminal domain;IPR006652 Kelch repeat type 1;IPR008979 Galactose-binding-like domain superfamily;IPR011043 Galactose oxidase/kelch, beta-propeller;IPR013783 Immunoglobulin-like fold;IPR014756 Immunoglobulin E-set;IPR015202 Galactose oxidase-like, Early set domain;IPR037293 Galactose oxidase, central domain superfamily AA5, CBM32 NA Antimicrobial 6STX; Copper oxidase from Colletotrichum graminicola; 4.678e-63 6RYX; Copper oxidase from Colletotrichum graminicola; 8.31e-62 A0A0S6X9K8; Galactose oxidase-like Early set domain-containing protein; Fungal sp. (strain No.11243); 9.183e-73 A0A2G5HG28; Galactose oxidase; Cercospora beticola (Sugarbeet leaf spot fungus); 6.199e-66
XANPAGTX0501_010688-T1 cl53 Galactose-binding domain Coagulation factor. different otherwise Non-DGE 0.58 66.59997 308 IPR000421 Coagulation factor 5/8 C-terminal domain;IPR008979 Galactose-binding-like domain superfamily AA5, CBM32 NA Non-antimicrobial 2VZ3; bleached galactose oxidase; 3.085e-16 2EIB; Crystal Structure of Galactose Oxidase, W290H mutant; 4.113e-16 W3WLU1; F5/8 type C domain-containing protein; Pestalotiopsis fici (strain W106-1 / CGMCC3.15140); 2.397e-14 A0A2R4TD26; Arabinogalactan endo-1,4-beta-galactosidase; Streptomyces lunaelactis; 3.01e-13
XANPAGTX0501_007392-T1 cl54 Chloroperoxidase Non-DGE 0.87 91.03036 249 IPR000028 Chloroperoxidase;IPR036851 Chloroperoxidase-like superfamily NA NA Non-antimicrobial 7O1X; Unspecific peroxygenase from Hypoxylon sp. EC38 in complex with 1-phenylimidazole; 4.226e-18 7ZNW; Artificial Unspecific Peroxygenase expressed in Escherichia coli at 2.09 Angstrom resolution; 1.492e-17 A0A1Q8S4R8; Putative sterigmatocystin biosynthesis peroxidase stcC 1; Colletotrichum chlorophyti; 8.958e-20 Q0CS13; Heme haloperoxidase family profile domain-containing protein; Aspergillus terreus (strain NIH 2624 / FGSC A1156); 3.941e-18
XANPAGTX0501_008027-T1 cl54 Chloroperoxidase Upregulated in lichen 0.69 66.39988 481 IPR000028 Chloroperoxidase;IPR036851 Chloroperoxidase-like superfamily NA NA Non-antimicrobial 7PN7; Evolved unspecific peroxygenase with A77L mutation in complex with palmitoleic acid; 2.227e-08 2YP1; Crystallization of a 45 kDa peroxygenase- peroxidase from the mushroom Agrocybe aegerita and structure determination by SAD utilizing only the haem iron; 1.326e-07 A0A098E104; Chromosome 3, complete genome; Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) (Wheat head blight fungus) (Fusarium graminearum); 1.377e-36 A0A366RUC2; deleted; ; 2.739e-34
XANPAGTX0501_000358-T1 cl55 FAD linked oxidase Non-DGE 0.9 92.58079 607 IPR006094 FAD linked oxidase, N-terminal;IPR012951 Berberine/berberine-like;IPR016166 FAD-binding domain, PCMH-type;IPR036318 FAD-binding, type PCMH-like superfamily AA7 NA Non-antimicrobial 6EO4; Physcomitrella patens BBE-like 1 wild-type; 1.746e-26 6EO5; Physcomitrella patens BBE-like 1 variant D396N; 2.213e-26 A0A093YD50; FAD-binding PCMH-type domain-containing protein; Pseudogymnoascus sp. VKM F-3808; 1.81e-84 A0A072Q3X7; FAD-binding PCMH-type domain-containing protein; Exophiala aquamarina CBS 119918; 3.119e-83
XANPAGTX0501_003196-T1 cl55 FAD linked oxidase Non-DGE 0.9 92.25110 590 IPR006094 FAD linked oxidase, N-terminal;IPR012951 Berberine/berberine-like;IPR016166 FAD-binding domain, PCMH-type;IPR036318 FAD-binding, type PCMH-like superfamily NA NA Antimicrobial 6F73; Crystal structure of VAO-type flavoprotein MtVAO615 at pH 5.0 from Myceliophthora thermophila C1; 1.182e-59 6F74; Crystal structure of VAO-type flavoprotein MtVAO713 from Myceliophthora thermophila C1; 1.424e-42 A0A2I1D0P8; Putative isoamyl alcohol oxidase; Aspergillus campestris (strain IBT 28561); 2.575e-87 G9MX01; FAD-binding PCMH-type domain-containing protein; Hypocrea virens (strain Gv29-8 / FGSC 10586) (Gliocladium virens) (Trichoderma virens); 4.968e-79
XANPAGTX0501_005715-T1 cl55 FAD linked oxidase Upregulated in lichen 0.91 95.06540 570 IPR006094 FAD linked oxidase, N-terminal;IPR012951 Berberine/berberine-like;IPR016166 FAD-binding domain, PCMH-type;IPR036318 FAD-binding, type PCMH-like superfamily AA7 NA Non-antimicrobial 6F73; Crystal structure of VAO-type flavoprotein MtVAO615 at pH 5.0 from Myceliophthora thermophila C1; 4.411e-65 6F74; Crystal structure of VAO-type flavoprotein MtVAO713 from Myceliophthora thermophila C1; 2.097e-49 A0A4Z1FDN5; FAD-binding PCMH-type domain-containing protein; Botrytis paeoniae; 1.168e-73 A0A7D8UU14; FAD-linked oxidoreductase ZEB1; Lachnellula cervina; 6.139e-73
XANPAGTX0501_000085-T1 cl56 flavoprotein EncM Non-DGE 0.88 90.60880 525 IPR006094 FAD linked oxidase, N-terminal;IPR012951 Berberine/berberine-like;IPR016166 FAD-binding domain, PCMH-type;IPR016167 FAD-binding, type PCMH, subdomain 1;IPR016169 FAD-binding, type PCMH, subdomain 2;IPR036318 FAD-binding, type PCMH-like superfamily AA7 NA Non-antimicrobial 6FYD; The crystal structure of EncM T139V mutant; 1.714e-28 6FYE; The crystal structure of EncM H138T mutant; 2.418e-28 A0A2V1CD15; FAD-binding domain-containing protein; Cadophora sp. DSE1049; 2.715e-63 A0A5N6T9G9; FAD-binding PCMH-type domain-containing protein; Aspergillus pseudotamarii; 1.602e-55
XANPAGTX0501_000553-T1 cl56 flavoprotein EncM Non-DGE 0.88 89.92460 500 IPR006094 FAD linked oxidase, N-terminal;IPR016166 FAD-binding domain, PCMH-type;IPR016167 FAD-binding, type PCMH, subdomain 1;IPR016169 FAD-binding, type PCMH, subdomain 2;IPR036318 FAD-binding, type PCMH-like superfamily AA7 NA Antimicrobial 6FYG; The crystal structure of EncM V135T mutant; 2.529e-32 6FYF; The crystal structure of EncM V135M mutant; 3.395e-32 A0A7C8MFV8; FAD-binding PCMH-type domain-containing protein; Xylaria multiplex; 2.738e-56 A0A0N0V6G3; 6-hydroxy-d-nicotine oxidase; Fusarium langsethiae; 1.266e-55
XANPAGTX0501_000933-T1 cl56 flavoprotein EncM Non-DGE 0.69 72.45520 225 IPR006094 FAD linked oxidase, N-terminal;IPR036318 FAD-binding, type PCMH-like superfamily NA NA Antimicrobial 6YJI; Structure of FgCelDH7C; 5.653e-06 5I1V; Crystal structure of CrmK, a flavoenzyme involved in the shunt product recycling mechanism in caerulomycin biosynthesis; 6.649e-05 A0A2C5YLF8; FAD-binding PCMH-type domain-containing protein; Ophiocordyceps camponoti-rufipedis; 2.403e-11 A0A369HF07; FAD-binding PCMH-type domain-containing protein; Ophiocordyceps camponoti-saundersi (nom. inval.); 2.327e-10
XANPAGTX0501_000935-T1 cl56 flavoprotein EncM Non-DGE 0.89 93.06261 510 IPR006094 FAD linked oxidase, N-terminal;IPR012951 Berberine/berberine-like;IPR016166 FAD-binding domain, PCMH-type;IPR036318 FAD-binding, type PCMH-like superfamily AA7 NA Non-antimicrobial 6FYC; The crystal structure of EncM L144M mutant complex with dioxygen under 15 bars O2 pressure; 1.226e-34 6FYG; The crystal structure of EncM V135T mutant; 2.009e-34 U1GF15; FAD-binding PCMH-type domain-containing protein; Endocarpon pusillum (strain Z07020 / HMAS-L-300199) (Lichen-forming fungus); 1.102e-73 A0A0S7DZK1; deleted; ; 7.946e-73
XANPAGTX0501_001002-T1 cl56 flavoprotein EncM Non-DGE 0.67 71.09031 292 IPR006094 FAD linked oxidase, N-terminal;IPR016166 FAD-binding domain, PCMH-type;IPR036318 FAD-binding, type PCMH-like superfamily AA7 NA Non-antimicrobial 2BVG; Crystal structure of 6-hydoxy-D-nicotine oxidase from Arthrobacter nicotinovorans. Crystal Form 1 (P21); 2.596e-12 6FYG; The crystal structure of EncM V135T mutant; 1.019e-10 A0A066XIG8; Putative FAD binding domain-containing protein; Colletotrichum sublineola (Sorghum anthracnose fungus); 3.909e-23 A0A6G1NQF4; deleted; ; 9.308e-23
XANPAGTX0501_001704-T1 cl56 flavoprotein EncM Non-DGE 0.9 92.45737 525 IPR006094 FAD linked oxidase, N-terminal;IPR016166 FAD-binding domain, PCMH-type;IPR036318 FAD-binding, type PCMH-like superfamily AA7 NA Non-antimicrobial 3W8X; The complex structure of EncM with trifluorotriketide; 6.867e-26 6FYF; The crystal structure of EncM V135M mutant; 1.02e-25 A0A3M7FU59; FAD-binding PCMH-type domain-containing protein; Hortaea werneckii; 1.198e-58 A0A3M7CH44; FAD-binding PCMH-type domain-containing protein; Hortaea werneckii; 5.208e-58
XANPAGTX0501_001974-T1 cl56 flavoprotein EncM Upregulated in culture 0.9 93.44082 500 IPR006094 FAD linked oxidase, N-terminal;IPR016166 FAD-binding domain, PCMH-type;IPR016167 FAD-binding, type PCMH, subdomain 1;IPR016169 FAD-binding, type PCMH, subdomain 2;IPR036318 FAD-binding, type PCMH-like superfamily AA7 NA Antimicrobial 3W8X; The complex structure of EncM with trifluorotriketide; 5.82e-30 6FYD; The crystal structure of EncM T139V mutant; 8.673e-30 A0A1W5CXF7; Uncharacterized conserved protein UCP028846; Lasallia pustulata; 7.835e-53 A0A5M8PLK7; FAD-binding PCMH-type domain-containing protein; Lasallia pustulata; 2.45e-52
XANPAGTX0501_002283-T1 cl56 flavoprotein EncM Non-DGE 0.89 90.04836 519 IPR006094 FAD linked oxidase, N-terminal;IPR016166 FAD-binding domain, PCMH-type;IPR016167 FAD-binding, type PCMH, subdomain 1;IPR016169 FAD-binding, type PCMH, subdomain 2;IPR036318 FAD-binding, type PCMH-like superfamily AA7 NA Non-antimicrobial 6FYE; The crystal structure of EncM H138T mutant; 4.851e-27 3W8X; The complex structure of EncM with trifluorotriketide; 4.851e-27 A0A5M8PCC7; FAD-binding PCMH-type domain-containing protein; Lasallia pustulata; 1.16e-65 A0A0F8A5J6; FAD-binding PCMH-type domain-containing protein; Hirsutella minnesotensis 3608; 2.187e-49
XANPAGTX0501_002304-T1 cl56 flavoprotein EncM Non-DGE 0.9 91.86230 526 IPR006094 FAD linked oxidase, N-terminal;IPR016166 FAD-binding domain, PCMH-type;IPR036318 FAD-binding, type PCMH-like superfamily AA7 NA Antimicrobial 6FYF; The crystal structure of EncM V135M mutant; 4.717e-27 6FYE; The crystal structure of EncM H138T mutant; 7.378e-27 T0JZW8; FAD-binding PCMH-type domain-containing protein; Colletotrichum gloeosporioides (strain Cg-14) (Anthracnose fungus) (Glomerella cingulata); 2.231e-49 A0A0B7KS85; FAD-binding PCMH-type domain-containing protein; Bionectria ochroleuca (Gliocladium roseum); 4.127e-49
XANPAGTX0501_003872-T1 cl56 flavoprotein EncM Non-DGE 0.89 93.21708 489 IPR006094 FAD linked oxidase, N-terminal;IPR012951 Berberine/berberine-like;IPR016166 FAD-binding domain, PCMH-type;IPR036318 FAD-binding, type PCMH-like superfamily AA7 NA Non-antimicrobial 6FYE; The crystal structure of EncM H138T mutant; 1.21e-30 6FYF; The crystal structure of EncM V135M mutant; 1.147e-29 A0A6A6CZV0; FAD-binding PCMH-type domain-containing protein; Zasmidium cellare ATCC 36951; 3.455e-62 A0A179F141; FAD binding domain-containing protein; Pochonia chlamydosporia 170; 6.244e-62
XANPAGTX0501_005256-T1 cl56 flavoprotein EncM Upregulated in lichen 0.91 93.62436 484 IPR006094 FAD linked oxidase, N-terminal;IPR012951 Berberine/berberine-like;IPR016166 FAD-binding domain, PCMH-type;IPR036318 FAD-binding, type PCMH-like superfamily AA7 NA Non-antimicrobial 6FYG; The crystal structure of EncM V135T mutant; 4.358e-34 6FYE; The crystal structure of EncM H138T mutant; 4.873e-34 A0A0U1LM91; FAD-binding PCMH-type domain-containing protein; Talaromyces islandicus (Penicillium islandicum); 2.488e-72 A0A6A5XLC8; FAD binding domain-containing protein; Aaosphaeria arxii CBS 175.79; 1.313e-70
XANPAGTX0501_005691-T1 cl56 flavoprotein EncM Upregulated in culture 0.91 93.68542 528 IPR006094 FAD linked oxidase, N-terminal;IPR016166 FAD-binding domain, PCMH-type;IPR036318 FAD-binding, type PCMH-like superfamily AA7 NA Non-antimicrobial 6FYE; The crystal structure of EncM H138T mutant; 7.372e-28 6FYF; The crystal structure of EncM V135M mutant; 7.807e-28 A0A6A7B452; FAD binding domain-containing protein; Plenodomus tracheiphilus IPT5; 6.701e-66 A0A6A5RB18; FAD binding domain-containing protein; Didymella exigua CBS 183.55; 2.971e-65
XANPAGTX0501_005748-T1 cl56 flavoprotein EncM Non-DGE 0.89 92.55604 508 IPR006094 FAD linked oxidase, N-terminal;IPR012951 Berberine/berberine-like;IPR016166 FAD-binding domain, PCMH-type;IPR016167 FAD-binding, type PCMH, subdomain 1;IPR016169 FAD-binding, type PCMH, subdomain 2;IPR036318 FAD-binding, type PCMH-like superfamily AA7 NA Non-antimicrobial 6FYE; The crystal structure of EncM H138T mutant; 1.14e-35 6FYG; The crystal structure of EncM V135T mutant; 2.093e-35 A0A0S7DZK1; deleted; ; 2.819e-67 U1GF15; FAD-binding PCMH-type domain-containing protein; Endocarpon pusillum (strain Z07020 / HMAS-L-300199) (Lichen-forming fungus); 2.853e-65
XANPAGTX0501_007268-T1 cl56 flavoprotein EncM Upregulated in lichen 0.89 92.37537 512 IPR006094 FAD linked oxidase, N-terminal;IPR016166 FAD-binding domain, PCMH-type;IPR036318 FAD-binding, type PCMH-like superfamily AA7 NA Non-antimicrobial 6FYF; The crystal structure of EncM V135M mutant; 7.054e-32 6FYG; The crystal structure of EncM V135T mutant; 4.082e-31 A0A0U5HGI3; FAD-binding PCMH-type domain-containing protein; Aspergillus calidoustus; 2.943e-60 A0A175WGG7; 6-hydroxy-D-nicotine oxidase; Madurella mycetomatis; 1.358e-59
XANPAGTX0501_010693-T1 cl56 flavoprotein EncM Upregulated in lichen 0.91 93.68269 528 IPR006094 FAD linked oxidase, N-terminal;IPR016166 FAD-binding domain, PCMH-type;IPR036318 FAD-binding, type PCMH-like superfamily AA7 NA Non-antimicrobial 6FYF; The crystal structure of EncM V135M mutant; 1.479e-26 3W8X; The complex structure of EncM with trifluorotriketide; 1.479e-26 A0A6A7B452; FAD binding domain-containing protein; Plenodomus tracheiphilus IPT5; 3.623e-65 A0A6A5RB18; FAD binding domain-containing protein; Didymella exigua CBS 183.55; 5.357e-64
XANPAGTX0501_000197-T1 cl57 SGNH hydrolase domain Non-DGE 0.71 78.66519 289 IPR013830 SGNH hydrolase-type esterase domain;IPR036514 SGNH hydrolase superfamily NA NA Non-antimicrobial 1ES9; X-RAY CRYSTAL STRUCTURE OF R22K MUTANT OF THE MAMMALIAN BRAIN PLATELET-ACTIVATING FACTOR ACETYLHYDROLASES (PAF-AH); 1.677e-09 1U8U; E. coli Thioesterase I/Protease I/Lysophospholiase L1 in complexed with octanoic acid; 8.877e-09 A0A1S9RGR2; SGNH hydrolase-type esterase domain-containing protein; Penicillium brasilianum; 2.107e-23 A0A1E1L4F0; Related to esterase; Rhynchosporium agropyri; 5.195e-22
XANPAGTX0501_007467-T1 cl57 SGNH hydrolase domain Upregulated in lichen 0.86 82.90107 571 IPR013830 SGNH hydrolase-type esterase domain;IPR036514 SGNH hydrolase superfamily CE3 NA Antimicrobial 7PZH; Phocaeicola vulgatus sialic acid esterase at 2.06 Angstrom resolution; 2.78e-06 7PZG; Phocaeicola vulgatus sialic acid esterase at 1.44 Angstrom resolution; 9.066e-06 W7N164; SGNH hydrolase-type esterase domain-containing protein; Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot fungus) (Fusarium verticillioides); 5.002e-19 A0A4E9DHT3; SGNH hydrolase-type esterase domain-containing protein; Gibberella zeae (Wheat head blight fungus) (Fusarium graminearum); 2.645e-18
XANPAGTX0501_003572-T1 cl58 GDSL lipase/esterase Upregulated in lichen 0.81 82.49739 360 IPR036514 SGNH hydrolase superfamily CE16 NA Antimicrobial 8H0B; Structure of the thermolabile hemolysin from Vibrio alginolyticus (in complex with oleic acid); 1.129e-12 8H0C; Structure of the thermolabile hemolysin from Vibrio alginolyticus (in complex with arachidonic acid); 2.153e-12 M3AVB5; Carbohydrate esterase family 16 protein; Pseudocercospora fijiensis (strain CIRAD86) (Black leaf streak disease fungus) (Mycosphaerella fijiensis); 4.657e-36 A0A3M7B1B8; Carbohydrate esterase family 16 protein; Hortaea werneckii; 5.553e-36
XANPAGTX0501_005514-T1 cl58 GDSL lipase/esterase Non-DGE 0.84 86.40883 358 IPR001087 GDSL lipase/esterase;IPR036514 SGNH hydrolase superfamily CE16 NA Non-antimicrobial 8D8X; Crystal structure of ChoE in complex with acetate and thiocholine (crystal form 2); 4.311e-12 6UR1; Crystal structure of ChoE S38A mutant in complex with acetate and acetylthiocholine; 8.311e-12 A0A6A6H321; Carbohydrate esterase family 16 protein; Viridothelium virens; 3.49e-32 S3DZ45; SGNH hydrolase; Glarea lozoyensis (strain ATCC 20868 / MF5171); 1.072e-29
XANPAGTX0501_009655-T1 cl58 GDSL lipase/esterase Non-DGE 0.86 88.23770 365 IPR001087 GDSL lipase/esterase;IPR036514 SGNH hydrolase superfamily CE16 NA Non-antimicrobial 8A25; Lysophospholipase PlaA from Legionella pneumophila str. Corby - complex with PEG fragment; 1.295e-12 8D8X; Crystal structure of ChoE in complex with acetate and thiocholine (crystal form 2); 2.664e-12 W3WNK7; Acetylesterase; Pestalotiopsis fici (strain W106-1 / CGMCC3.15140); 3.124e-26 A0A6A6CTA7; Carbohydrate esterase family 16 protein; Zasmidium cellare ATCC 36951; 2.957e-23
XANPAGTX0501_001127-T1 cl59 GH128 Upregulated in lichen 0.67 77.67610 400 IPR017853 Glycoside hydrolase superfamily;IPR024655 Asl1-like, glycosyl hydrolase catalytic domain GH128 NA Antimicrobial 6UAZ; Crystal structure of a GH128 (subgroup III) curdlan-specific exo-beta-1,3-glucanase from Blastomyces gilchristii (BgGH128_III) in complex with glucose; 2.53e-20 6UB8; Crystal structure of a GH128 (subgroup VI) exo-beta-1,3-glucanase from Aureobasidium namibiae (AnGH128_VI); 2.873e-13 A0A4U0XZ18; Asl1-like glycosyl hydrolase catalytic domain-containing protein; Friedmanniomyces simplex; 2.147e-24 A0A4S9M8I3; Asl1-like glycosyl hydrolase catalytic domain-containing protein; Aureobasidium pullulans (Black yeast) (Pullularia pullulans); 4.826e-22
XANPAGTX0501_001832-T1 cl59 GH128 Upregulated in lichen 0.61 70.01544 421 IPR017853 Glycoside hydrolase superfamily;IPR024655 Asl1-like, glycosyl hydrolase catalytic domain GH128 NA Antimicrobial 6UBC; Crystal structure of a GH128 (subgroup VII) oligosaccharide-binding protein from Cryptococcus neoformans (CnGH128_VII); 4.359e-10 4QAW; Structure of modular Xyn30D from Paenibacillus barcinonensis; 2.911e-06 A0A2K0TQW1; Asl1-like glycosyl hydrolase catalytic domain-containing protein; Trichoderma gamsii; 1.125e-29 A0A5M3MMY0; Asl1-like glycosyl hydrolase catalytic domain-containing protein; Coniophora puteana (strain RWD-64-598) (Brown rot fungus); 6.626e-29
XANPAGTX0501_004870-T1 cl59 GH128 Non-DGE 0.84 90.95345 229 IPR017853 Glycoside hydrolase superfamily;IPR024655 Asl1-like, glycosyl hydrolase catalytic domain GH128 NA Non-antimicrobial 6UB4; Crystal structure (C2 form) of a GH128 (subgroup IV) endo-beta-1,3-glucanase from Lentinula edodes (LeGH128_IV) in complex with laminaritriose; 1.018e-11 6UB8; Crystal structure of a GH128 (subgroup VI) exo-beta-1,3-glucanase from Aureobasidium namibiae (AnGH128_VI); 2.325e-11 A0A6G1GWR7; Glycoside hydrolase family 128 protein; Aulographum hederae CBS 113979; 5.252e-31 A0A6G1JBK6; Glycoside hydrolase family 128 protein; Lentithecium fluviatile CBS 122367; 1.04e-29
XANPAGTX0501_005416-T1 cl59 GH128 Non-DGE 0.71 75.55260 350 IPR017853 Glycoside hydrolase superfamily;IPR024655 Asl1-like, glycosyl hydrolase catalytic domain GH128 NA Antimicrobial 6UFZ; Crystal structure of a GH128 (subgroup I) endo-beta-1,3-glucanase (E199Q mutant) from Amycolatopsis mediterranei (AmGH128_I); 7.325e-17 6UAR; Crystal structure of a GH128 (subgroup I) endo-beta-1,3-glucanase from Amycolatopsis mediterranei (AmGH128_I) in complex with laminaritriose; 2.379e-16 A0A5M8PWH0; Asl1-like glycosyl hydrolase catalytic domain-containing protein; Lasallia pustulata; 1.03e-23 A0A818Z082; Asl1-like glycosyl hydrolase catalytic domain-containing protein; Rotaria sordida; 9.788e-18
XANPAGTX0501_008596-T1 cl59 GH128 Non-DGE 0.83 83.71293 300 IPR017853 Glycoside hydrolase superfamily;IPR024655 Asl1-like, glycosyl hydrolase catalytic domain GH128 NA Antimicrobial 6UB7; Crystal structure of a GH128 (subgroup V) exo-beta-1,3-glucanase from Cryptococcus neoformans (CnGH128_V); 3.067e-12 6UBD; Crystal structure of a GH128 (subgroup VII) oligosaccharide-binding protein from Trichoderma gamsii (TgGH128_VII); 6.315e-12 A0A2K0TQW1; Asl1-like glycosyl hydrolase catalytic domain-containing protein; Trichoderma gamsii; 1.181e-19 A0A5M3MMY0; Asl1-like glycosyl hydrolase catalytic domain-containing protein; Coniophora puteana (strain RWD-64-598) (Brown rot fungus); 2.432e-19
XANPAGTX0501_006873-T1 cl60 Spherulation Non-DGE 0.9 94.67271 258 IPR021986 Spherulation-specific family 4 GH135 NA Non-antimicrobial 5D6T; Crystal Structure of Aspergillus clavatus Sph3 in complex with GalNAc; 1.124e-18 7OMS; Bs164 in complex with mannocyclophellitol aziridine; 0.0007705 A0A370U1V6; Spherulation-specific family 4; Venustampulla echinocandica; 8.008e-24 S3DAA7; Spherulin-4; Glarea lozoyensis (strain ATCC 20868 / MF5171); 8.705e-23
XANPAGTX0501_009750-T1 cl60 Spherulation Non-DGE 0.73 78.92304 158 IPR021986 Spherulation-specific family 4 GH135 NA Non-antimicrobial 5D6T; Crystal Structure of Aspergillus clavatus Sph3 in complex with GalNAc; 3.322e-05 NA A0A1W5DBE1; Spherulation-specific family 4; Lasallia pustulata; 1.304e-06 A0A6G1H548; 1,3-beta-glucanosyltransferase; Aulographum hederae CBS 113979; 4.207e-06
XANPAGTX0501_004284-T1 cl61 GH71 Non-DGE 0.88 89.86701 432 IPR005197 Glycoside hydrolase family 71 GH71 NA Non-antimicrobial NA NA A0A5M9JWB1; Glycoside hydrolase family 71 protein; Monilinia fructicola (Brown rot fungus) (Ciboria fructicola); 6.415e-36 A0A2T3APP8; Glycoside hydrolase family 71 protein; Amorphotheca resinae ATCC 22711; 9.088e-36
XANPAGTX0501_009731-T1 cl61 GH71 Upregulated in lichen 0.72 76.92287 647 IPR005197 Glycoside hydrolase family 71 GH71 NA Non-antimicrobial 6ZFQ; Structure of the catalytic domain of human endo-alpha-mannosidase MANEA in complex with bis-tris; 1.055e-08 3KL3; Crystal structure of Ligand bound XynC; 0.0002456 A0A7C8NY73; Mutanase; Orbilia oligospora (Nematode-trapping fungus) (Arthrobotrys oligospora); 1.419e-76 A0A093ZD78; Mutanase; Pseudogymnoascus sp. VKM F-4246; 7.507e-76
XANPAGTX0501_007944-T1 cl62 GH20 Non-DGE 0.92 92.37711 599 IPR015883 Glycoside hydrolase family 20, catalytic domain;IPR017853 Glycoside hydrolase superfamily;IPR025705 Beta-hexosaminidase;IPR029018 Beta-hexosaminidase-like, domain 2;IPR029019 Beta-hexosaminidase, eukaryotic type, N-terminal GH20 NA Antimicrobial 3OZP; Crystal Structure of insect beta-N-acetyl-D-hexosaminidase OfHex1 complexed with PUGNAc; 2.608e-43 5Y0V; Crystal Structure of insect beta-N-acetyl-D-hexosaminidase OfHex1 complexed with berberine; 3.09e-43 A0A3M6WFM8; beta-N-acetylhexosaminidase (EC 3.2.1.52); Hortaea werneckii; 8.129e-80 A0A3M7BSS0; beta-N-acetylhexosaminidase (EC 3.2.1.52); Hortaea werneckii; 6.255e-75
XANPAGTX0501_008404-T2 cl62 GH20 Non-DGE 0.9 89.93681 590 IPR015883 Glycoside hydrolase family 20, catalytic domain;IPR017853 Glycoside hydrolase superfamily;IPR025705 Beta-hexosaminidase;IPR029018 Beta-hexosaminidase-like, domain 2;IPR029019 Beta-hexosaminidase, eukaryotic type, N-terminal GH20 NA Non-antimicrobial 5Y0V; Crystal Structure of insect beta-N-acetyl-D-hexosaminidase OfHex1 complexed with berberine; 2.654e-46 3OZP; Crystal Structure of insect beta-N-acetyl-D-hexosaminidase OfHex1 complexed with PUGNAc; 4.219e-46 A0A545UNY0; Beta-hexosaminidase (EC 3.2.1.52); Cordyceps javanica; 2.017e-63 A0A2U3EF51; Beta-hexosaminidase (EC 3.2.1.52); Purpureocillium lilacinum (Paecilomyces lilacinus); 1.986e-56
XANPAGTX0501_005771-T1 cl63 GH5 Upregulated in lichen 0.92 93.06367 403 IPR001547 Glycoside hydrolase, family 5;IPR017853 Glycoside hydrolase superfamily GH5 NA Non-antimicrobial 2PF0; F258I mutant of EXO-B-(1,3)-GLUCANASE FROM CANDIDA ALBICANS at 1.9 A; 1.402e-21 2PB1; Exo-B-(1,3)-Glucanase from Candida Albicans in complex with unhydrolysed and covalently linked 2,4-dinitrophenyl-2-deoxy-2-fluoro-B-D-glucopyranoside at 1.9 A; 8.811e-21 A0A5J5EJS4; glucan endo-1,6-beta-glucosidase (EC 3.2.1.75) (Beta-1,6-glucanase B) (Endo-1,6-beta-D-glucanase B) (Endo-1,6-beta-glucanase B); Sphaerosporella brunnea; 1.055e-55 A0A397HJG6; glucan endo-1,6-beta-glucosidase (EC 3.2.1.75) (Beta-1,6-glucanase B) (Endo-1,6-beta-D-glucanase B) (Endo-1,6-beta-glucanase B); Aspergillus thermomutatus; 1.742e-52
XANPAGTX0501_005824-T1 cl63 GH5 Non-DGE 0.9 92.80199 418 IPR001547 Glycoside hydrolase, family 5;IPR017853 Glycoside hydrolase superfamily GH5 NA Antimicrobial 4M82; The structure of E292S glycosynthase variant of exo-1,3-beta-glucanase from Candida albicans complexed with p-nitrophenyl-gentiobioside (product) at 1.6A resolution; 1.877e-49 2PC8; E292Q mutant of EXO-B-(1,3)-Glucanase from Candida Albicans in complex with two separately bound glucopyranoside units at 1.8 A; 5.568e-49 A0A559M7G4; glucan 1,3-beta-glucosidase (EC 3.2.1.58); Lachnellula willkommii; 7.832e-58 A0A420IS96; glucan 1,3-beta-glucosidase (EC 3.2.1.58); Golovinomyces cichoracearum; 2.427e-56
XANPAGTX0501_009065-T1 cl63 GH5 Non-DGE 0.9 92.81578 419 IPR001547 Glycoside hydrolase, family 5;IPR017853 Glycoside hydrolase superfamily;IPR018087 Glycoside hydrolase, family 5, conserved site GH5 NA Antimicrobial 1EQP; EXO-B-(1,3)-GLUCANASE FROM CANDIDA ALBICANS; 3.583e-49 2PC8; E292Q mutant of EXO-B-(1,3)-Glucanase from Candida Albicans in complex with two separately bound glucopyranoside units at 1.8 A; 1.207e-48 A0A178AJ34; Glycoside hydrolase; Stagonospora sp. SRC1lsM3a; 1.595e-55 K5X1J2; glucan 1,3-beta-glucosidase (EC 3.2.1.58); Phanerochaete carnosa (strain HHB-10118-sp) (White-rot fungus) (Peniophora carnosa); 1.233e-45
XANPAGTX0501_002331-T1 cl64 GH5 Upregulated in lichen 0.64 70.62403 573 IPR001547 Glycoside hydrolase, family 5;IPR017853 Glycoside hydrolase superfamily;IPR018087 Glycoside hydrolase, family 5, conserved site GH5 NA Antimicrobial 3QR3; Crystal Structure of Cel5A (EG2) from Hypocrea jecorina (Trichoderma reesei); 4.629e-49 5D8Z; Structrue of a lucidum protein; 1.253e-45 A0A1B8CR24; cellulase (EC 3.2.1.4); Pseudogymnoascus sp. WSF 3629; 3.403e-46 A0A094H9E2; cellulase (EC 3.2.1.4); Pseudogymnoascus sp. VKM F-4520 (FW-2644); 7.692e-46
XANPAGTX0501_007383-T1 cl64 GH5 Non-DGE 0.88 90.37385 405 IPR001547 Glycoside hydrolase, family 5;IPR017853 Glycoside hydrolase superfamily GH5 NA Non-antimicrobial 3ZIZ; Crystal structure of Podospora anserina GH5 beta-(1,4)-mannanase; 3.625e-43 3WFL; Crtstal structure of glycoside hydrolase family 5 beta-mannanase from Talaromyces trachyspermus; 2.356e-42 A0A162LAP6; mannan endo-1,4-beta-mannosidase (EC 3.2.1.78); Niveomyces insectorum RCEF 264; 4.197e-44 A0A4V5NGM5; mannan endo-1,4-beta-mannosidase (EC 3.2.1.78); Cryomyces minteri; 6.802e-44
XANPAGTX0501_001051-T1 cl65 GH72 Upregulated in culture 0.7 76.37445 416 IPR017853 Glycoside hydrolase superfamily GH17 NA Non-antimicrobial 8AKP; Crystal structure of the catalytic domain of G7048 from Penicillium sumatraense; 2.194e-15 4WTS; Active-site mutant of Rhizomucor miehei beta-1,3-glucanosyltransferase in complex with laminaritriose; 5.135e-14 A0A395SU71; Probable beta-glucosidase btgE (Beta-D-glucoside glucohydrolase btgE) (Cellobiase btgE) (Gentiobiase btgE); Fusarium longipes; 9.187e-34 A0A2T4C9H5; Probable beta-glucosidase btgE (Beta-D-glucoside glucohydrolase btgE) (Cellobiase btgE) (Gentiobiase btgE); Trichoderma longibrachiatum ATCC 18648; 2.681e-33
XANPAGTX0501_001599-T1 cl65 GH72 Non-DGE 0.83 86.79342 456 IPR004886 Glucanosyltransferase;IPR017853 Glycoside hydrolase superfamily GH72 NA Non-antimicrobial 5O9Y; Crystal structure of ScGas2 in complex with compound 11; 4.595e-37 5O9O; Crystal structure of ScGas2 in complex with compound 7.; 1.36e-36 A0A1W5D808; 1,3-beta-glucanosyltransferase (EC 2.4.1.-); Lasallia pustulata; 3.523e-65 A0A420J2Q4; 1,3-beta-glucanosyltransferase (EC 2.4.1.-); Golovinomyces cichoracearum; 2.868e-62
XANPAGTX0501_003500-T1 cl65 GH72 Non-DGE 0.67 80.84327 388 IPR000490 Glycoside hydrolase family 17;IPR017853 Glycoside hydrolase superfamily GH17 NA Non-antimicrobial 4WTS; Active-site mutant of Rhizomucor miehei beta-1,3-glucanosyltransferase in complex with laminaritriose; 2.36e-16 4WTP; Crystal structure of glycoside hydrolase family 17 beta-1,3-glucanosyltransferase from Rhizomucor miehei; 9.217e-16 A0A0F4GCX7; Cell wall glucanase like protein; Zymoseptoria brevis; 1.213e-36 A0A1X7S612; Methyltransferase small domain-containing protein; Zymoseptoria tritici ST99CH_3D7; 1.2e-35
XANPAGTX0501_003503-T1 cl65 GH72 Non-DGE 0.85 87.99634 538 IPR004886 Glucanosyltransferase;IPR012946 X8 domain;IPR017853 Glycoside hydrolase superfamily GH72 NA Non-antimicrobial 2W61; Saccharomyces cerevisiae Gas2p apostructure (E176Q mutant); 1.777e-52 5OA2; Crystal structure of ScGas2 in complex with compound 8; 2e-52 A0A3M7ML87; 1,3-beta-glucanosyltransferase (EC 2.4.1.-); Chaetothyriales sp. CBS 132003; 2.491e-68 A0A074VCF9; 1,3-beta-glucanosyltransferase (EC 2.4.1.-); Aureobasidium melanogenum CBS 110374; 1.029e-65
XANPAGTX0501_004305-T1 cl65 GH72 Non-DGE 0.86 87.30977 481 IPR004886 Glucanosyltransferase;IPR017853 Glycoside hydrolase superfamily GH72 NA Non-antimicrobial 5OA2; Crystal structure of ScGas2 in complex with compound 8; 8.071e-34 5FIH; SACCHAROMYCES CEREVISIAE GAS2P (E176Q MUTANT) IN COMPLEX WITH LAMINARITETRAOSE AND LAMINARIPENTAOSE; 2.427e-33 A0A6A6QJZ1; 1,3-beta-glucanosyltransferase (EC 2.4.1.-); Lophium mytilinum; 2.102e-68 A0A6A6V308; 1,3-beta-glucanosyltransferase (EC 2.4.1.-); Sporormia fimetaria CBS 119925; 1.374e-65
XANPAGTX0501_004466-T1 cl65 GH72 Non-DGE 0.56 80.16331 601 IPR000490 Glycoside hydrolase family 17;IPR017853 Glycoside hydrolase superfamily;IPR018620 Ubiquitin 3 binding protein But2, C-terminal NA NA Antimicrobial 8AKP; Crystal structure of the catalytic domain of G7048 from Penicillium sumatraense; 6.144e-38 4WTP; Crystal structure of glycoside hydrolase family 17 beta-1,3-glucanosyltransferase from Rhizomucor miehei; 5.218e-17 N4VAI7; deleted; ; 1.886e-44 A0A3N2Q222; Probable glucan endo-1,3-beta-glucosidase eglC (EC 3.2.1.39) (Endo-1,3-beta-glucanase eglC) (Laminarinase eglC); Sodiomyces alkalinus F11; 9.08e-44
XANPAGTX0501_006257-T1 cl65 GH72 Upregulated in lichen 0.89 94.78313 291 IPR000490 Glycoside hydrolase family 17;IPR017853 Glycoside hydrolase superfamily NA NA Antimicrobial 8AKP; Crystal structure of the catalytic domain of G7048 from Penicillium sumatraense; 1.983e-32 4WTS; Active-site mutant of Rhizomucor miehei beta-1,3-glucanosyltransferase in complex with laminaritriose; 3.139e-22 A0A2I0SA18; deleted; ; 1.918e-41 A0A178CKP3; deleted; ; 6.839e-40
XANPAGTX0501_007287-T1 cl65 GH72 Non-DGE 0.82 85.42341 434 IPR004886 Glucanosyltransferase;IPR017853 Glycoside hydrolase superfamily GH72 NA Non-antimicrobial 5OA6; Crystal structure of ScGas2 in complex with compound 12; 1.396e-34 5O9Q; Crystal structure of ScGas2 in complex with compound 6; 1.396e-34 A0A6A6TZ55; 1,3-beta-glucanosyltransferase (EC 2.4.1.-); Microthyrium microscopicum; 4.63e-54 A0A0D1XJS0; 1,3-beta-glucanosyltransferase (EC 2.4.1.-); Verruconis gallopava; 2.182e-53
XANPAGTX0501_006694-T1 cl66 No annotation Upregulated in culture 0.85 90.17522 341 NA NA NA Non-antimicrobial NA NA A0A4S8T8Y1; Apple domain-containing protein; Aureobasidium pullulans (Black yeast) (Pullularia pullulans); 3.811e-41 A0A074Y7S9; Apple domain-containing protein; Aureobasidium subglaciale (strain EXF-2481) (Aureobasidium pullulans var. subglaciale); 1.565e-39
XANPAGTX0501_009026-T1 cl66 No annotation Upregulated in lichen 0.65 67.83616 177 NA NA NA Non-antimicrobial NA NA NA NA
XANPAGTX0501_001458-T1 cl67 Kremen-like Upregulated in lichen 0.64 78.90771 532 IPR002889 Carbohydrate-binding WSC;IPR018535 Domain of unknown function DUF1996 NA NA Antimicrobial 7PZ2; Structure of the mechanosensor domain of Wsc1 from Saccharomyces cerevisiae; 4.487e-06 6SNW; Structure of Coxsackievirus A10 complexed with its receptor KREMEN1; 9.741e-06 A0A1Y2AVJ5; WSC domain-containing protein; Naematelia encephala; 3.032e-38 A0A1Y2B2Z9; WSC domain-containing protein; Naematelia encephala; 1.358e-34
XANPAGTX0501_002771-T1 cl67 Kremen-like Non-DGE 0.61 75.45871 178 IPR002889 Carbohydrate-binding WSC AA2, AA5 NA Non-antimicrobial 5FWW; Wnt modulator Kremen in complex with DKK1 (CRD2) and LRP6 (PE3PE4); 1.086e-07 6SNW; Structure of Coxsackievirus A10 complexed with its receptor KREMEN1; 3.365e-07 A0A072PVC9; WSC domain-containing protein; Exophiala aquamarina CBS 119918; 2.666e-12 A0A6A6P5T9; Heme peroxidase; Lineolata rhizophorae; 2.83e-12
XANPAGTX0501_003112-T1 cl67 Kremen-like Non-DGE 0.9 93.07371 665 IPR002889 Carbohydrate-binding WSC;IPR009880 Glyoxal oxidase, N-terminal;IPR011043 Galactose oxidase/kelch, beta-propeller;IPR013783 Immunoglobulin-like fold;IPR014756 Immunoglobulin E-set;IPR015202 Galactose oxidase-like, Early set domain;IPR037293 Galactose oxidase, central domain superfamily AA2, AA5 NA Antimicrobial 6STX; Copper oxidase from Colletotrichum graminicola; 4.114e-31 5LXZ; W288A mutant of GlxA from Streptomyces lividans: Cu-bound form; 4.81e-30 A0A4V1XWP0; WSC domain-containing protein; Monosporascus sp. 5C6A; 5.601e-99 A0A1Y2VRL5; Putative glyoxal oxidase; Hypoxylon sp. CI-4A; 3.044e-97
XANPAGTX0501_004685-T1 cl67 Kremen-like Non-DGE 0.78 88.96366 913 IPR002889 Carbohydrate-binding WSC;IPR009880 Glyoxal oxidase, N-terminal;IPR011043 Galactose oxidase/kelch, beta-propeller;IPR013783 Immunoglobulin-like fold;IPR014756 Immunoglobulin E-set;IPR015202 Galactose oxidase-like, Early set domain;IPR037293 Galactose oxidase, central domain superfamily AA2, AA5 NA Non-antimicrobial 6STX; Copper oxidase from Colletotrichum graminicola; 2.141e-33 6RYX; Copper oxidase from Colletotrichum graminicola; 4.446e-31 A0A6G1JP04; Copper radical oxidase; Lentithecium fluviatile CBS 122367; 0 A0A6A6RTD7; Galactose oxidase; Massarina eburnea CBS 473.64; 0
XANPAGTX0501_004854-T1 cl67 Kremen-like Non-DGE 0.63 79.35459 181 IPR002889 Carbohydrate-binding WSC AA2, AA5 NA Non-antimicrobial 5FWW; Wnt modulator Kremen in complex with DKK1 (CRD2) and LRP6 (PE3PE4); 3.968e-07 5FWU; Wnt modulator Kremen crystal form II at 2.8A; 7.84e-07 A0A165GMI8; WSC-domain-containing protein; Xylona heveae (strain CBS 132557 / TC161); 6.159e-15 A0A3D8RVQ0; WSC domain-containing protein; Coleophoma crateriformis; 6.159e-15
XANPAGTX0501_005800-T1 cl67 Kremen-like Non-DGE 0.67 78.73468 1514 IPR002889 Carbohydrate-binding WSC;IPR013783 Immunoglobulin-like fold AA2, AA5 NA Non-antimicrobial 7SQC; Ciliary C1 central pair apparatus isolated from Chlamydomonas reinhardtii; 5.29e-17 7PZ2; Structure of the mechanosensor domain of Wsc1 from Saccharomyces cerevisiae; 4.85e-05 R8BN75; Putative wsc domain-containing protein; Phaeoacremonium minimum (strain UCR-PA7) (Esca disease fungus) (Togninia minima); 0 A0A437AGZ5; WSC domain-containing protein; Arthrobotrys flagrans; 0
XANPAGTX0501_009572-T1 cl67 Kremen-like Non-DGE 0.7 85.71615 794 IPR002016 Haem peroxidase;IPR002889 Carbohydrate-binding WSC;IPR010255 Haem peroxidase superfamily AA2, AA5 NA Antimicrobial 8FF7; Cytosolic ascorbate peroxidase mutant from Panicum virgatum- ascorbate complex; 1.377e-08 3ZCY; Ascorbate peroxidase W41A-H42Y mutant; 1.615e-08 A0A6A6P5T9; Heme peroxidase; Lineolata rhizophorae; 3.304e-90 A0A370TW43; Heme peroxidase; Venustampulla echinocandica; 7.554e-86
XANPAGTX0501_010118-T1 cl67 Kremen-like Non-DGE 0.52 74.70309 2081 IPR002889 Carbohydrate-binding WSC;IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily AA2, AA5 NA Non-antimicrobial 7SQC; Ciliary C1 central pair apparatus isolated from Chlamydomonas reinhardtii; 8.1e-15 7SQC; Ciliary C1 central pair apparatus isolated from Chlamydomonas reinhardtii; 3.215e-13 H0EM97; Putative fungistatic metabolite; Glarea lozoyensis (strain ATCC 74030 / MF5533); 9.154e-99 A0A4T0C0S1; WSC-domain-containing protein; Aureobasidium pullulans (Black yeast) (Pullularia pullulans); 9.171e-72
XANPAGTX0501_000163-T1 cl68 Ferritin-like Upregulated in lichen 0.86 91.00356 315 IPR009078 Ferritin-like superfamily NA NA Non-antimicrobial NA NA A0A094BZK6; Ferritin-like diiron domain-containing protein; Pseudogymnoascus sp. VKM F-4513 (FW-928); 5.765e-39 A0A0B7KBV2; Ferritin/DPS protein domain-containing protein; Bionectria ochroleuca (Gliocladium roseum); 3.362e-38
XANPAGTX0501_002552-T1 cl68 Ferritin-like Non-DGE 0.87 89.67626 478 NA NA NA Antimicrobial NA NA A0A5N6T127; Ferritin-like domain-containing protein; Aspergillus pseudotamarii; 2.84e-71 A0A5M8PU89; Protein rds1; Lasallia pustulata; 1.359e-56
XANPAGTX0501_000923-T1 cl69 Purple acid phosphatase-like Upregulated in lichen 0.92 92.24466 618 IPR008963 Purple acid phosphatase-like, N-terminal;IPR018946 PhoD-like phosphatase, metallophosphatase domain;IPR032093 Phospholipase D, N-terminal;IPR038607 PhoD-like superfamily NA NA Non-antimicrobial 2YEQ; Structure of PhoD; 1.934e-48 NA A0A2C5ZCQ5; C2 domain-containing protein; Ophiocordyceps camponoti-rufipedis; 1.341e-92 A0A4Q4UE84; PhoD-like phosphatase metallophosphatase domain-containing protein; Monosporascus sp. MC13-8B; 6.986e-90
XANPAGTX0501_006265-T1 cl69 Purple acid phosphatase-like Non-DGE 0.91 90.39639 634 IPR008963 Purple acid phosphatase-like, N-terminal;IPR018946 PhoD-like phosphatase, metallophosphatase domain;IPR032093 Phospholipase D, N-terminal;IPR038607 PhoD-like superfamily NA NA Antimicrobial 2YEQ; Structure of PhoD; 3.102e-53 6GJ9; PURPLE ACID PHYTASE FROM WHEAT ISOFORM B2 - REGENERATION COMPLEX; 2.269e-19 A0A074VYT3; Phosphodiesterase/alkaline phosphatase D; Aureobasidium melanogenum CBS 110374; 0 N4VQ28; deleted; ; 0
XANPAGTX0501_004252-T1 cl70 AA9 Non-DGE 0.74 81.70142 466 IPR001002 Chitin-binding, type 1;IPR005103 Auxiliary Activity family 9;IPR013087 Zinc finger C2H2-type;IPR018371 Chitin-binding, type 1, conserved site;IPR036861 Endochitinase-like superfamily AA9 NA Antimicrobial 5NLT; CvAA9A; 8.281e-22 6RS9; X-ray crystal structure of LsAA9B (xylotetraose soak); 2.967e-19 A0A1W5D0F1; Multifunctional fusion protein [Includes: Endo-beta-1,4-glucanase D (Endoglucanase D) (EC 3.2.1.4) (Carboxymethylcellulase D) (Cellulase D); Histone H4]; Lasallia pustulata; 1.356e-49 A0A397IHD3; Endo-beta-1,4-glucanase D (Endoglucanase D) (EC 3.2.1.4) (Carboxymethylcellulase D) (Cellulase D); Aspergillus turcosus; 4.083e-48
XANPAGTX0501_010366-T1 cl70 AA9 Upregulated in lichen 0.59 71.09143 441 IPR005103 Auxiliary Activity family 9 AA9 NA Antimicrobial 7A8V; Crystal structure of Polysaccharide monooxygenase from P.verruculosum; 3.565e-40 6H1Z; AFGH61B WILD-TYPE; 4.501e-37 A0A093YIK5; Endo-beta-1,4-glucanase D (Endoglucanase D) (EC 3.2.1.4) (Carboxymethylcellulase D) (Cellulase D); Pseudogymnoascus sp. VKM F-3808; 8.832e-40 A0A094A1Y7; Endo-beta-1,4-glucanase D (Endoglucanase D) (EC 3.2.1.4) (Carboxymethylcellulase D) (Cellulase D); Pseudogymnoascus sp. VKM F-4281 (FW-2241); 3.025e-39
XANPAGTX0501_000361-T1 cl71 Chitin-binding. matching by small part Non-DGE 0.61 83.70659 211 IPR001002 Chitin-binding, type 1;IPR036861 Endochitinase-like superfamily CBM18, CE4 NA Antimicrobial 9WGA; 2.2 ANGSTROMS RESOLUTION STRUCTURE ANALYSIS OF TWO REFINED N-ACETYLNEURAMINYLLACTOSE-WHEAT GERM AGGLUTININ ISOLECTIN COMPLEXES; 4.497e-09 4AML; CRYSTAL STRUCTURE OF WHEAT GERM AGGLUTININ ISOLECTIN 1 IN COMPLEX WITH GLYCOSYLURETHAN; 6.024e-08 A0A3M7MIS9; Chitin binding; Pyrenophora seminiperda CCB06; 6.297e-29 A0A6A5YEJ0; Carbohydrate-binding module family 18 protein; Saccharata proteae CBS 121410; 2.714e-25
XANPAGTX0501_001885-T1 cl71 Chitin-binding. matching by small part Non-DGE 0.81 91.10910 577 IPR001002 Chitin-binding, type 1;IPR006094 FAD linked oxidase, N-terminal;IPR012951 Berberine/berberine-like;IPR016166 FAD-binding domain, PCMH-type;IPR016167 FAD-binding, type PCMH, subdomain 1;IPR016169 FAD-binding, type PCMH, subdomain 2;IPR036318 FAD-binding, type PCMH-like superfamily;IPR036861 Endochitinase-like superfamily AA7 NA Antimicrobial 6YJO; Structure of FgChi7B; 3.163e-48 6Y0R; Chitooligosaccharide oxidase; 2.435e-47 A0A6A6J9Y6; FAD-binding domain-containing protein; Westerdykella ornata; 1.209e-73 A0A6P8AR07; Uncharacterized protein; Pyricularia grisea (Crabgrass-specific blast fungus) (Magnaporthe grisea); 9.974e-72
XANPAGTX0501_002353-T1 cl71 Chitin-binding. matching by small part Non-DGE 0.77 83.01192 828 IPR001002 Chitin-binding, type 1;IPR009880 Glyoxal oxidase, N-terminal;IPR011043 Galactose oxidase/kelch, beta-propeller;IPR013783 Immunoglobulin-like fold;IPR014756 Immunoglobulin E-set;IPR015202 Galactose oxidase-like, Early set domain;IPR036861 Endochitinase-like superfamily;IPR037293 Galactose oxidase, central domain superfamily AA2, AA5 NA Antimicrobial 2EIC; Crystal Structure of Galactose Oxidase mutant W290F; 3.114e-28 6RYX; Copper oxidase from Colletotrichum graminicola; 6.243e-28 A0A6A5YBN8; Carbohydrate-binding module family 18; Aaosphaeria arxii CBS 175.79; 0 A0A6A5S2H8; Carbohydrate-binding module family 18; Didymella exigua CBS 183.55; 0
XANPAGTX0501_007748-T1 cl71 Chitin-binding. matching by small part Non-DGE 0.59 79.13302 557 IPR001002 Chitin-binding, type 1;IPR002509 NodB homology domain;IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel;IPR018371 Chitin-binding, type 1, conserved site;IPR036861 Endochitinase-like superfamily CBM18, CE4 NA Antimicrobial 2IW0; Structure of the chitin deacetylase from the fungal pathogen Colletotrichum lindemuthianum; 9.071e-24 7BLY; Structure of the chitin deacetylase AngCDA from Aspergillus niger; 7.847e-21 A0A2T7A6C8; Glycoside hydrolase/deacetylase; Tuber borchii (White truffle); 1.912e-53 A0A1W5D7M5; Uncharacterized domain YCR061W, C-terminal; Lasallia pustulata; 2.188e-42
XANPAGTX0501_009511-T1 cl71 Chitin-binding. matching by small part Upregulated in lichen 0.72 79.12778 405 IPR000757 Glycoside hydrolase family 16;IPR001002 Chitin-binding, type 1;IPR013320 Concanavalin A-like lectin/glucanase domain superfamily;IPR036861 Endochitinase-like superfamily GH16 NA Antimicrobial 3AXD; The truncated Fibrobacter succinogenes 1,3-1,4-beta-D-glucanase V18Y/W203Y in apo-form; 1.371e-09 3HR9; The truncated Fibrobacter succinogenes 1,3-1,4-beta-D-glucanase F40I mutant; 2.009e-09 A0A4U0U2S3; GH16 domain-containing protein; Salinomyces thailandica; 4.012e-23 A0A066VPL4; GH16 domain-containing protein; Rhizoctonia solani AG-8 WAC10335; 6.797e-21
XANPAGTX0501_001516-T1 cl72 Phosphatidylethanolamine-binding protein Non-DGE 0.71 77.76382 272 IPR008914 Phosphatidylethanolamine-binding protein;IPR035810 Phosphatidylethanolamine-binding protein, eukaryotic;IPR036610 PEBP-like superfamily NA NA Non-antimicrobial 1WKP; Flowering locus t (ft) from arabidopsis thaliana; 3.856e-09 6IGJ; Crystal structure of FT condition 4; 1.152e-08 A0A6A6CBM2; PEBP-like protein; Zasmidium cellare ATCC 36951; 1.859e-15 A0A0S6XKH3; Uncharacterized protein; Fungal sp. (strain No.11243); 3.042e-15
XANPAGTX0501_008387-T1 cl72 Phosphatidylethanolamine-binding protein Non-DGE 0.73 71.57141 283 IPR008914 Phosphatidylethanolamine-binding protein;IPR035810 Phosphatidylethanolamine-binding protein, eukaryotic;IPR036610 PEBP-like superfamily NA I51 Non-antimicrobial 5TVD; Crystal structure of Tm16; 3.122e-14 6IGJ; Crystal structure of FT condition 4; 5.386e-14 A0A3D8SPB3; PEBP-like protein; Coleophoma cylindrospora; 6.497e-22 A0A2T7A9B5; Phosphatidylethanolamine-binding protein; Tuber borchii (White truffle); 1.518e-21
XANPAGTX0501_000801-T1 cl73 No annotation Non-DGE 0.69 77.33250 224 NA NA NA Non-antimicrobial NA NA A0A4U0XF57; Copper transport protein; Cryomyces minteri; 2.217e-18 A0A0D2C558; Copper acquisition factor BIM1-like domain-containing protein; Exophiala oligosperma; 3.814e-17
XANPAGTX0501_004004-T1 cl73 No annotation Non-DGE 0.74 83.51603 239 NA NA NA Non-antimicrobial NA NA A0A0S7E3P3; Copper acquisition factor BIM1-like domain-containing protein; Aspergillus lentulus; 1.753e-28 A0A0U1LWF8; Copper acquisition factor BIM1-like domain-containing protein; Talaromyces islandicus (Penicillium islandicum); 1.956e-28
XANPAGTX0501_006291-T1 cl74 No annotation Upregulated in lichen 0.54 65.71913 160 NA NA NA Antimicrobial NA NA NA NA
XANPAGTX0501_010442-T1 cl74 No annotation Upregulated in culture 0.57 65.98594 160 NA NA NA Antimicrobial 3PDG; Structures of Clostridium thermocellum CbhA fibronectin(III)-like modules; 0.0005652 NA NA NA
XANPAGTX0501_003237-T1 cl75 Endonuclease/exonuclease/phosphatase Non-DGE 0.86 90.48891 531 IPR036691 Endonuclease/exonuclease/phosphatase superfamily NA NA Non-antimicrobial NA NA A0A1V8V0E0; Endonuclease/exonuclease/phosphatase domain-containing protein; Rachicladosporium sp. CCFEE 5018; 3.478e-69 A0A0N1H0H2; Endonuclease/exonuclease/phosphatase domain-containing protein; Phialophora attinorum; 6.712e-58
XANPAGTX0501_006312-T1 cl75 Endonuclease/exonuclease/phosphatase Non-DGE 0.92 95.35402 617 IPR036691 Endonuclease/exonuclease/phosphatase superfamily NA NA Antimicrobial 3MPR; Crystal Structure of endonuclease/exonuclease/phosphatase family protein from Bacteroides thetaiotaomicron, Northeast Structural Genomics Consortium Target BtR318A; 2.66e-12 5J3Z; Crystal structure of m2hTDP2-CAT in complex with a small molecule inhibitor; 1.604e-10 A0A2W1HX62; deleted; ; 5.723e-77 A0A513ZSD8; Endonuclease/exonuclease/phosphatase family protein; Cordyceps militaris (Caterpillar fungus) (Clavaria militaris); 2.75e-62
XANPAGTX0501_006272-T1 cl76 Aminopeptidase M28 Non-DGE 0.91 93.62283 374 IPR007484 Peptidase M28 NA M28E Non-antimicrobial 6ICA; The crystal structure of Legionella pneumophila LapA aminopeptidase; 1.829e-25 6ICA; The crystal structure of Legionella pneumophila LapA aminopeptidase; 3.471e-25 A0A0B7K3C1; Peptide hydrolase (EC 3.4.-.-); Bionectria ochroleuca (Gliocladium roseum); 3.858e-43 A0A0F4Z9C9; Peptide hydrolase (EC 3.4.-.-); Thielaviopsis punctulata; 5.039e-43
XANPAGTX0501_006687-T1 cl76 Aminopeptidase M28 Non-DGE 0.89 92.02210 386 IPR007484 Peptidase M28 NA M28E Non-antimicrobial 6ICA; The crystal structure of Legionella pneumophila LapA aminopeptidase; 1.184e-28 6ICA; The crystal structure of Legionella pneumophila LapA aminopeptidase; 2.371e-28 A0A094DR96; Peptide hydrolase (EC 3.4.-.-); Pseudogymnoascus sp. VKM F-4515 (FW-2607); 4.826e-60 A0A6G1JZI7; Peptide hydrolase (EC 3.4.-.-); Pleomassaria siparia CBS 279.74; 6.444e-60
XANPAGTX0501_006220-T1 cl77 Patulin synthase Non-DGE 0.83 84.85463 367 IPR000172 Glucose-methanol-choline oxidoreductase, N-terminal;IPR036188 FAD/NAD(P)-binding domain superfamily AA3 NA Non-antimicrobial 8BXL; Patulin Synthase from Penicillium expansum; 2.047e-30 6YRX; Low-dose crystal structure of FAP at room temperature; 5.39e-19 A0A0N1HAN7; Versicolorin B synthase; Phialophora attinorum; 2.268e-35 A0A0U1LYJ0; Versicolorin B synthase; Talaromyces islandicus (Penicillium islandicum); 4.409e-35
XANPAGTX0501_009862-T1 cl77 Patulin synthase Non-DGE 0.84 84.50499 391 IPR000172 Glucose-methanol-choline oxidoreductase, N-terminal;IPR036188 FAD/NAD(P)-binding domain superfamily AA3 NA Non-antimicrobial 8BXL; Patulin Synthase from Penicillium expansum; 2.617e-36 5OC1; Crystal structure of aryl-alcohol oxidase from Pleurotus eryngii in complex with p-anisic acid; 3.111e-25 A0A6A6I6J7; GMC oxidoreductase; Trematosphaeria pertusa; 6.552e-45 A0A5M8PRZ8; Versicolorin b synthase; Lasallia pustulata; 3.558e-44
XANPAGTX0501_001675-T1 cl78 Cholin/aryl-alcohol oxidase Non-DGE 0.92 92.20677 619 IPR000172 Glucose-methanol-choline oxidoreductase, N-terminal;IPR007867 Glucose-methanol-choline oxidoreductase, C-terminal;IPR012132 Glucose-methanol-choline oxidoreductase;IPR036188 FAD/NAD(P)-binding domain superfamily AA3 NA Antimicrobial 3FIM; Crystal structure of aryl-alcohol-oxidase from Pleurotus eryingii; 1.624e-51 7R33; Difference-refined structure of fatty acid photodecarboxylase 20 ps following 400-nm laser irradiation of the dark-state determined by SFX; 2.145e-46 A0A6A7ARW9; GMC oxidoreductase; Plenodomus tracheiphilus IPT5; 2.523e-91 A0A6A4HEV5; Alcohol oxidase; Gymnopus androsaceus JB14; 1.386e-74
XANPAGTX0501_002462-T1 cl78 Cholin/aryl-alcohol oxidase Non-DGE 0.92 93.55743 612 IPR000172 Glucose-methanol-choline oxidoreductase, N-terminal;IPR007867 Glucose-methanol-choline oxidoreductase, C-terminal;IPR012132 Glucose-methanol-choline oxidoreductase;IPR036188 FAD/NAD(P)-binding domain superfamily AA3 NA Non-antimicrobial 7R33; Difference-refined structure of fatty acid photodecarboxylase 20 ps following 400-nm laser irradiation of the dark-state determined by SFX; 3.686e-53 6YS1; Crystal structure of FAP R451K mutant in the dark at 100K; 1.239e-51 A0A4Z1J5Y0; Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein; Botrytis elliptica; 3.656e-98 A0A6A6RAV7; Alcohol oxidase; Lophium mytilinum; 1.776e-87
XANPAGTX0501_002692-T1 cl78 Cholin/aryl-alcohol oxidase Non-DGE 0.92 91.25600 635 IPR000172 Glucose-methanol-choline oxidoreductase, N-terminal;IPR007867 Glucose-methanol-choline oxidoreductase, C-terminal;IPR012132 Glucose-methanol-choline oxidoreductase;IPR036188 FAD/NAD(P)-binding domain superfamily AA3 NA Non-antimicrobial 3LJP; Crystal structure of choline oxidase V464A mutant; 2.471e-52 2JBV; Crystal structure of choline oxidase reveals insights into the catalytic mechanism; 2.162e-51 A0A1S8B712; Choline dehydrogenase; Diplodia seriata; 5.274e-90 R1FVG2; Putative gmc oxidoreductase protein; Botryosphaeria parva (strain UCR-NP2) (Grapevine canker fungus) (Neofusicoccum parvum); 3.386e-89
XANPAGTX0501_002963-T1 cl78 Cholin/aryl-alcohol oxidase Non-DGE 0.61 64.93838 1156 IPR000172 Glucose-methanol-choline oxidoreductase, N-terminal;IPR007867 Glucose-methanol-choline oxidoreductase, C-terminal;IPR036188 FAD/NAD(P)-binding domain superfamily AA3 NA Below pLDDT threshold 6O9N; Structural insights on a new fungal aryl-alcohol oxidase; 4.054e-58 7VKD; Reduced enzyme of FAD-dpendent Glucose Dehydrogenase at pH6.5; 4.231e-57 A0A5M8PKB2; Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein; Lasallia pustulata; 0 A0A1W5CT22; Glucose-methanol-choline oxidoreductase, N-terminal; Lasallia pustulata; 0
XANPAGTX0501_003140-T1 cl78 Cholin/aryl-alcohol oxidase Upregulated in culture 0.87 87.53881 695 IPR000172 Glucose-methanol-choline oxidoreductase, N-terminal;IPR007867 Glucose-methanol-choline oxidoreductase, C-terminal;IPR012132 Glucose-methanol-choline oxidoreductase;IPR036188 FAD/NAD(P)-binding domain superfamily AA3 NA Non-antimicrobial 8BXL; Patulin Synthase from Penicillium expansum; 3.439e-88 5OC1; Crystal structure of aryl-alcohol oxidase from Pleurotus eryngii in complex with p-anisic acid; 1.932e-53 A0A6V8H8J1; Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein; Talaromyces pinophilus (Penicillium pinophilum); 1.158e-102 A0A420RG73; Versicolorin B synthase; Fusarium oxysporum (Fusarium vascular wilt); 6.15e-86
XANPAGTX0501_005244-T1 cl78 Cholin/aryl-alcohol oxidase Upregulated in culture 0.92 93.05731 629 IPR000172 Glucose-methanol-choline oxidoreductase, N-terminal;IPR007867 Glucose-methanol-choline oxidoreductase, C-terminal;IPR012132 Glucose-methanol-choline oxidoreductase;IPR036188 FAD/NAD(P)-binding domain superfamily AA3 NA Non-antimicrobial 4YNT; Crystal structure of Aspergillus flavus FAD glucose dehydrogenase; 1.274e-54 5OC1; Crystal structure of aryl-alcohol oxidase from Pleurotus eryngii in complex with p-anisic acid; 2.585e-53 A0A084RWW1; deleted; ; 5.607e-75 A0A2S6BXM5; Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein; Cercospora berteroae; 3.165e-69
XANPAGTX0501_009758-T1 cl78 Cholin/aryl-alcohol oxidase Non-DGE 0.9 89.26037 595 IPR000172 Glucose-methanol-choline oxidoreductase, N-terminal;IPR007867 Glucose-methanol-choline oxidoreductase, C-terminal;IPR012132 Glucose-methanol-choline oxidoreductase;IPR036188 FAD/NAD(P)-binding domain superfamily AA3 NA Antimicrobial 5OC1; Crystal structure of aryl-alcohol oxidase from Pleurotus eryngii in complex with p-anisic acid; 2.842e-51 3FIM; Crystal structure of aryl-alcohol-oxidase from Pleurotus eryingii; 5.959e-49 A0A317VTY9; Alcohol oxidase; Aspergillus sclerotioniger CBS 115572; 3.092e-71 A0A6V8H8J1; Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein; Talaromyces pinophilus (Penicillium pinophilum); 1.757e-69
XANPAGTX0501_007624-T1 cl79 No annotation Non-DGE 0.6 62.86249 289 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_008290-T1 cl79 No annotation Non-DGE 0.73 74.65504 236 NA NA NA Antimicrobial NA NA A0A136J8L8; Cyanovirin-N domain-containing protein; Microdochium bolleyi; 0.0002174 D4AMW3; Uncharacterized secreted protein ARB_05566; Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes); 0.0009542
XANPAGTX0501_009606-T1 cl80 Gamma-crystallin-like Upregulated in lichen 0.6 79.86218 142 NA NA NA Non-antimicrobial 1HDF; Evolution of the eye lens beta-gamma-crystallin domain fold; 1.302e-05 3SNZ; Crystal structure of a mutant W39D of a betagamma-crystallin domain from Clostridium beijerinckii; 0.0001275 A0A1B8G710; Uncharacterized protein; Pseudogymnoascus verrucosus; 2.272e-10 A0A4T0W2D3; Uncharacterized protein; Colletotrichum higginsianum; 8.437e-10
XANPAGTX0501_009649-T1 cl80 Gamma-crystallin-like Non-DGE 0.73 84.10992 125 NA NA NA Non-antimicrobial NA NA A0A1L9T545; Uncharacterized protein; Aspergillus sydowii CBS 593.65; 1.401e-08 A0A1Y2W4B1; Uncharacterized protein; Hypoxylon sp. CI-4A; 2.365e-06
XANPAGTX0501_000740-T1 cl81 Aspartic peptidase Non-DGE 0.7 68.28128 592 IPR001461 Aspartic peptidase A1 family;IPR021109 Aspartic peptidase domain superfamily;IPR033121 Peptidase family A1 domain;IPR033876 Secreted aspartic endopeptidase NA A01A Antimicrobial 7AGB; Protease Sapp1p from Candida parapsilosis in complex with KB70; 2.331e-34 1J71; Structure of the extracellular aspartic proteinase from Candida tropicalis yeast.; 4.586e-34 A0A0D2APD0; Peptidase A1 domain-containing protein; Verruconis gallopava; 5.708e-42 A0A842Z296; deleted; ; 4.08e-36
XANPAGTX0501_000747-T1 cl81 Aspartic peptidase Non-DGE 0.83 80.26111 468 IPR001461 Aspartic peptidase A1 family;IPR001969 Aspartic peptidase, active site;IPR021109 Aspartic peptidase domain superfamily;IPR033121 Peptidase family A1 domain;IPR033876 Secreted aspartic endopeptidase NA A01A Antimicrobial 1J71; Structure of the extracellular aspartic proteinase from Candida tropicalis yeast.; 2.402e-36 2QZW; Secreted aspartic proteinase (Sap) 1 from Candida albicans; 7.453e-36 A0A2G7FL77; Aspartic-type endopeptidase opsB; Aspergillus arachidicola; 5.992e-42 A0A225APP5; Putative aspartic-type endopeptidase opsB; Talaromyces atroroseus; 1.968e-41
XANPAGTX0501_003097-T1 cl81 Aspartic peptidase Non-DGE 0.81 78.76526 392 IPR001461 Aspartic peptidase A1 family;IPR021109 Aspartic peptidase domain superfamily;IPR033121 Peptidase family A1 domain NA A01A Antimicrobial 6RSV; Endothiapepsin in complex with 017; 1.597e-27 4YCY; Endothiapepsin in complex with fragment 218; 2.192e-26 A0A0D1XMT6; Peptidase A1 domain-containing protein; Verruconis gallopava; 4.332e-27 A0A2B7YGS7; Peptidase A1 domain-containing protein; Polytolypa hystricis UAMH7299; 9.718e-26
XANPAGTX0501_003124-T1 cl81 Aspartic peptidase Upregulated in lichen 0.84 83.03405 440 IPR001461 Aspartic peptidase A1 family;IPR001969 Aspartic peptidase, active site;IPR021109 Aspartic peptidase domain superfamily;IPR033121 Peptidase family A1 domain;IPR034164 Pepsin-like domain NA A01A Non-antimicrobial 1UH8; Crystal structure of rhizopuspepsin at pH 8.0; 2.348e-23 5APR; STRUCTURES OF COMPLEXES OF RHIZOPUSPEPSIN WITH PEPSTATIN AND OTHER STATINE-CONTAINING INHIBITORS; 5.573e-23 A0A0G2EMW1; Putative aspartic-type; Phaeomoniella chlamydospora; 3.931e-42 A0A4S8ZDK6; Acid protease; Aureobasidium pullulans (Black yeast) (Pullularia pullulans); 1.222e-41
XANPAGTX0501_003693-T1 cl81 Aspartic peptidase Non-DGE 0.84 83.69188 399 IPR001461 Aspartic peptidase A1 family;IPR001969 Aspartic peptidase, active site;IPR021109 Aspartic peptidase domain superfamily;IPR033121 Peptidase family A1 domain NA A01A Antimicrobial 1FMX; STRUCTURE OF NATIVE PROTEINASE A IN THE SPACE GROUP P21; 8.943e-50 1FMU; STRUCTURE OF NATIVE PROTEINASE A IN P3221 SPACE GROUP.; 8.586e-49 A0A232M6J5; Peptidase A1 domain-containing protein; Elaphomyces granulatus; 2.51e-56 F8MUL2; Aspartic proteinase, pepstatin-sensitive; Neurospora tetrasperma (strain FGSC 2508 / ATCC MYA-4615 / P0657); 5.627e-55
XANPAGTX0501_004043-T1 cl81 Aspartic peptidase Non-DGE 0.82 82.46504 425 IPR001461 Aspartic peptidase A1 family;IPR001969 Aspartic peptidase, active site;IPR021109 Aspartic peptidase domain superfamily;IPR033121 Peptidase family A1 domain;IPR034163 Aspergillopepsin-like catalytic domain NA A01A Non-antimicrobial 2WEC; ACID PROTEINASE (PENICILLOPEPSIN) (E.C.3.4.23.20) COMPLEX WITH PHOSPHONATE INHIBITOR: METHYL(2S)-[1-(((N-(1-NAPHTHALENEACETYL))-L-VALYL)AMINOMETHYL)HYDROXY PHOSPHINYLOXY]-3-PHENYLPROPANOATE, SODIUM SALT; 6.328e-42 4YCT; Endothiapepsin in complex with fragment 216; 2.059e-41 A0A507AUA0; Peptidase A1 domain-containing protein; Thyridium curvatum; 9.039e-46 A0A165HBS6; Putative extracellular aspartic endopeptidase; Xylona heveae (strain CBS 132557 / TC161); 2.099e-45
XANPAGTX0501_007515-T1 cl81 Aspartic peptidase Upregulated in lichen 0.82 86.80152 396 IPR001461 Aspartic peptidase A1 family;IPR001969 Aspartic peptidase, active site;IPR021109 Aspartic peptidase domain superfamily;IPR033121 Peptidase family A1 domain;IPR034163 Aspergillopepsin-like catalytic domain NA A01A Antimicrobial 4Y48; Endothiapepsin in complex with fragment B50; 1.001e-47 6RSV; Endothiapepsin in complex with 017; 1.001e-47 A0A1Q8RB75; Endothiapepsin; Colletotrichum chlorophyti; 3.9e-53 A0A4S9M350; Peptidase A1 domain-containing protein; Aureobasidium pullulans (Black yeast) (Pullularia pullulans); 1.653e-52
XANPAGTX0501_008754-T1 cl81 Aspartic peptidase Non-DGE 0.8 78.96484 483 IPR001461 Aspartic peptidase A1 family;IPR001969 Aspartic peptidase, active site;IPR021109 Aspartic peptidase domain superfamily;IPR033121 Peptidase family A1 domain;IPR033876 Secreted aspartic endopeptidase NA A01A Antimicrobial 7AGB; Protease Sapp1p from Candida parapsilosis in complex with KB70; 1.616e-35 3FV3; Secreted aspartic protease 1 from Candida parapsilosis in complex with pepstatin A; 7.405e-34 A0A1J9QJZ9; Aspartic-type endopeptidase; Diplodia corticola; 1.179e-47 A1C4K0; Yapsin; Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107); 2.616e-44
XANPAGTX0501_005657-T1 cl82 No annotation Non-DGE 0.57 57.60056 482 NA NA NA Below pLDDT threshold NA NA A0A5M8Q482; Uncharacterized protein; Lasallia pustulata; 2.576e-22 A0A2K9YE87; Uncharacterized protein; Cladonia uncialis subsp. uncialis; 2.496e-20
XANPAGTX0501_006967-T1 cl82 No annotation Upregulated in lichen 0.6 63.78815 504 NA NA NA Below pLDDT threshold NA NA A0A2K9YE87; Uncharacterized protein; Cladonia uncialis subsp. uncialis; 4.59e-24 A0A5M8Q482; Uncharacterized protein; Lasallia pustulata; 1.422e-23
XANPAGTX0501_007280-T1 cl82 No annotation Upregulated in lichen 0.63 59.71566 401 NA NA NA Below pLDDT threshold NA NA A0A2K9YE87; Uncharacterized protein; Cladonia uncialis subsp. uncialis; 5.734e-18 A0A5M8Q482; Uncharacterized protein; Lasallia pustulata; 2.469e-17
XANPAGTX0501_000106-T1 cl83 Papain inbitor Non-DGE 0.72 67.79074 202 IPR036908 RlpA-like domain superfamily NA NA Non-antimicrobial 3X2L; X-ray structure of PcCel45A apo form at 95K.; 2.454e-09 3X2H; X-ray structure of PcCel45A N92D with cellopentaose at 95K.; 5.375e-09 A0A0E0F0C5; Expansin; Oryza meridionalis; 0.0005526 A0A6P6U5N5; Expansin-like B1 isoform X2; Coffea arabica (Arabian coffee); 0.0005526
XANPAGTX0501_001015-T1 cl83 Papain inbitor Upregulated in lichen 0.79 88.99895 143 IPR036908 RlpA-like domain superfamily NA NA Non-antimicrobial 5NTB; Streptomyces papain inhibitor (SPI); 1.228e-09 4AVR; Crystal structure of the hypothetical protein Pa4485 from Pseudomonas aeruginosa; 5.917e-07 S3CYI0; Barwin-like endoglucanase; Glarea lozoyensis (strain ATCC 20868 / MF5171); 4.104e-19 A0A0C3H1Y4; RlpA-like protein double-psi beta-barrel domain-containing protein; Oidiodendron maius (strain Zn); 1.522e-18
XANPAGTX0501_005809-T1 cl83 Papain inbitor Non-DGE 0.81 90.24906 128 IPR001153 Barwin domain;IPR036908 RlpA-like domain superfamily NA NA Antimicrobial 5NTB; Streptomyces papain inhibitor (SPI); 3.868e-10 7WVR; Crystal structure of Talaromyces leycettanus JCM12802 expansin; 5.306e-07 A0A6G1HT02; RlpA-like protein double-psi beta-barrel domain-containing protein; Trichodelitschia bisporula; 1.825e-13 A0A367J2H3; RlpA-like protein double-psi beta-barrel domain-containing protein; Rhizopus stolonifer (Rhizopus nigricans); 7.186e-12
XANPAGTX0501_006194-T1 cl83 Papain inbitor Upregulated in lichen 0.79 88.48266 154 IPR036908 RlpA-like domain superfamily NA NA Antimicrobial 3X2P; Neutron and X-ray joint refined structure of PcCel45A with cellopentaose at 298K.; 1.055e-10 3X2H; X-ray structure of PcCel45A N92D with cellopentaose at 95K.; 1.122e-10 A0A4U0URI0; CBM1 domain-containing protein; Friedmanniomyces endolithicus; 4.21e-14 A0A3M7AHM8; CBM1 domain-containing protein; Hortaea werneckii; 1.959e-13
XANPAGTX0501_009885-T1 cl83 Papain inbitor Non-DGE 0.69 80.85400 190 IPR009009 RlpA-like protein, double-psi beta-barrel domain;IPR036908 RlpA-like domain superfamily NA NA Non-antimicrobial 5NTB; Streptomyces papain inhibitor (SPI); 4.147e-10 7WVR; Crystal structure of Talaromyces leycettanus JCM12802 expansin; 7.484e-09 A0A1D1VXJ0; Expansin-like EG45 domain-containing protein; Ramazzottius varieornatus (Water bear) (Tardigrade); 6.686e-14 A0A1R1Y825; Papain inhibitor; Smittium culicis; 1.948e-13
XANPAGTX0501_000099-T1 not in cluster NA Non-DGE 0.88 90.33257 385 IPR009486 Purine nucleoside permease NA NA Non-antimicrobial 3EEI; Crystal structure of 5’-methylthioadenosine/S-adenosylhomocysteine nucleosidase from neisseria meningitidis in complex with methylthio-immucillin-A; 1.541e-12 1Z5O; Crystal structure of MTA/AdoHcy nucleosidase Asp197Asn mutant complexed with 5’-methylthioadenosine; 1.638e-12 A0A094HNX8; Helicase ATP-binding domain-containing protein; Pseudogymnoascus sp. VKM F-4519 (FW-2642); 2.911e-55 A0A1V6QYV1; Purine nucleoside permease; Penicillium solitum; 2.707e-53
XANPAGTX0501_000467-T1 not in cluster NA Upregulated in lichen 0.52 52.38919 161 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_000626-T1 not in cluster NA Non-DGE 0.5 64.90024 328 IPR008972 Cupredoxin NA NA Below pLDDT threshold 3BQV; Crystal Structure of the double mutant D44A D45A Plastocyanin from Phormidium laminosum; 6.543e-08 4R0O; Crystal structure of PEGylated plastocyanin at 4.2 A resolution; 8.918e-08 A0A2T3AXE3; Phytocyanin domain-containing protein; Amorphotheca resinae ATCC 22711; 3.987e-22 A0A6A6GXA8; Phytocyanin domain-containing protein; Viridothelium virens; 6.475e-21
XANPAGTX0501_000633-T1 not in cluster NA Non-DGE 0.68 70.34727 326 IPR001223 Glycoside hydrolase family 18, catalytic domain;IPR011583 Chitinase II;IPR017853 Glycoside hydrolase superfamily GH18 NA Non-antimicrobial 1E6N; Chitinase B from Serratia marcescens inactive mutant E144Q in complex with N-acetylglucosamine-pentamer; 5.632e-13 4Z2H; Serratia marcescens Chitinase B complexed with macrolide inhibitor 29; 7.292e-13 A0A6A6VMZ0; chitinase (EC 3.2.1.14); Sporormia fimetaria CBS 119925; 2.347e-28 A0A1W2TM45; chitinase (EC 3.2.1.14); Rosellinia necatrix (White root-rot fungus); 1.341e-27
XANPAGTX0501_000833-T1 not in cluster NA Non-DGE 0.81 85.55586 244 IPR012349 FMN-binding split barrel NA NA Non-antimicrobial 1XHN; The crystal structure of Cellular Repressor of E1A-stimulated Genes (CREG); 8.145e-11 2HQ9; Crystal structure of a fad-binding protein (mll6688) from mesorhizobium loti at 1.95 A resolution; 9.275e-06 A0A7C8IBI1; Pyridoxamine 5’-phosphate oxidase-domain-containing protein; Massariosphaeria phaeospora; 7.769e-29 A0A545A0I8; deleted; ; 6.809e-27
XANPAGTX0501_001028-T1 not in cluster NA Non-DGE 0.63 66.45818 556 IPR000172 Glucose-methanol-choline oxidoreductase, N-terminal;IPR036188 FAD/NAD(P)-binding domain superfamily AA3 NA Antimicrobial 1KDG; Crystal structure of the flavin domain of cellobiose dehydrogenase; 3.678e-33 4QI7; Cellobiose dehydrogenase from Neurospora crassa, NcCDH; 4.108e-32 L8G156; Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein; Pseudogymnoascus destructans (strain ATCC MYA-4855 / 20631-21) (Bat white-nose syndrome fungus) (Geomyces destructans); 2.656e-43 M3D149; FAD/NAD(P)-binding domain-containing protein; Sphaerulina musiva (strain SO2202) (Poplar stem canker fungus) (Septoria musiva); 7.147e-43
XANPAGTX0501_001083-T1 not in cluster NA Non-DGE 0.64 70.77810 601 IPR007266 Endoplasmic reticulum oxidoreductin 1;IPR037192 ERO1-like superfamily NA NA Non-antimicrobial 1RQ1; Structure of Ero1p, Source of Disulfide Bonds for Oxidative Protein Folding in the Cell; 2.83e-18 3M31; Structure of the C150A/C295A mutant of S. cerevisiae Ero1p; 3.257e-18 A0A4S8MEM9; Endoplasmic oxidoreductin; Dendrothele bispora (strain CBS 962.96); 7.411e-25 A0A1Y1VH03; Endoplasmic oxidoreductin; Piromyces finnis; 9.816e-25
XANPAGTX0501_001094-T1 not in cluster NA Non-DGE 0.51 72.94346 463 IPR013766 Thioredoxin domain;IPR017937 Thioredoxin, conserved site;IPR036249 Thioredoxin-like superfamily NA NA Non-antimicrobial 3ED3; Crystal Structure of the Yeast Dithiol/Disulfide Oxidoreductase Mpd1p; 5.614e-22 5GU6; Crystal structure of Human ERp44 form I; 3.746e-16 A0A1W5DAQ3; Disulfide isomerase; Lasallia pustulata; 4.161e-49 A0A1R3RS37; Thioredoxin domain-containing protein; Aspergillus carbonarius (strain ITEM 5010); 7.582e-47
XANPAGTX0501_001104-T1 not in cluster NA Non-DGE 0.72 76.57498 466 IPR018805 Cell wall protein YJL171C/Tos1, C-terminal;IPR018807 Cell wall protein YJL171C/Tos1, N-terminal NA NA Antimicrobial NA NA A0A0G2I0T9; glucan endo-1,3-beta-D-glucosidase (EC 3.2.1.39); Emmonsia crescens UAMH 3008; 7.324e-44 W9YCH4; glucan endo-1,3-beta-D-glucosidase (EC 3.2.1.39); Capronia epimyces CBS 606.96; 1.256e-41
XANPAGTX0501_001259-T1 not in cluster NA Non-DGE 0.81 82.29719 352 IPR022751 Alpha-mannosyltransferase;IPR029044 Nucleotide-diphospho-sugar transferases GT71 NA Antimicrobial 4UEG; Crystal structure of human glycogenin-2 catalytic domain; 0.0008143 NA A0A0D8JT77; Alpha-1,3-mannosyltransferase; Coccidioides immitis (strain RS) (Valley fever fungus); 2.444e-32 A0A072PC86; Alpha-1,3-mannosyltransferase; Exophiala aquamarina CBS 119918; 4.853e-32
XANPAGTX0501_001264-T1 not in cluster NA Non-DGE 0.9 91.90525 577 IPR001362 Glycoside hydrolase, family 32;IPR013148 Glycosyl hydrolase family 32, N-terminal;IPR013189 Glycosyl hydrolase family 32, C-terminal;IPR013320 Concanavalin A-like lectin/glucanase domain superfamily;IPR018053 Glycoside hydrolase, family 32, active site;IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain superfamily GH32 NA Non-antimicrobial 8BEQ; Structure of fructofuranosidase from Rhodotorula dairenensis; 6.094e-67 8BEU; Structure of D188A-fructofuranosidase from Rhodotorula dairenensis in complex with raffinose; 2.911e-66 A0A067TBQ3; Glycosyl hydrolase family 32 N-terminal domain-containing protein; Galerina marginata (strain CBS 339.88); 8.249e-79 A0A4T0B7E3; Glycosyl hydrolase family 32 N-terminal domain-containing protein; Aureobasidium pullulans (Black yeast) (Pullularia pullulans); 8.913e-76
XANPAGTX0501_001663-T1 not in cluster NA Non-DGE 0.66 66.74461 271 IPR000111 Glycoside hydrolase family 27/36, conserved site;IPR002241 Glycoside hydrolase, family 27;IPR013785 Aldolase-type TIM barrel;IPR017853 Glycoside hydrolase superfamily NA NA Non-antimicrobial 3A5V; Crystal structure of alpha-galactosidase I from Mortierella vinacea; 2.572e-24 3LXC; Interconversion of Human Lysosomal Enzyme Specificities; 4.085e-20 A0A0F7STC2; Alpha-galactosidase (EC 3.2.1.22) (Melibiase); Phaffia rhodozyma (Yeast) (Xanthophyllomyces dendrorhous); 2.926e-23 A0A2N5US34; Alpha-galactosidase (EC 3.2.1.22) (Melibiase); Puccinia coronata f. sp. avenae; 7.35e-23
XANPAGTX0501_001758-T1 not in cluster NA Non-DGE 0.82 86.77719 327 IPR002472 Palmitoyl protein thioesterase;IPR029058 Alpha/Beta hydrolase fold NA NA Non-antimicrobial 3GRO; Human palmitoyl-protein thioesterase 1; 1.497e-32 1EXW; CRYSTAL STRUCTURE OF PALMITOYL PROTEIN THIOESTERASE 1 COMPLEXED WITH HEXADECYLSULFONYL FLUORIDE; 4.429e-32 A0A3D8RZZ4; Palmitoyl-protein thioesterase 1 (EC 3.1.2.22) (Palmitoyl-protein hydrolase 1); Coleophoma cylindrospora; 1.619e-47 A0A136IMG9; Palmitoyl-protein thioesterase 1 (EC 3.1.2.22) (Palmitoyl-protein hydrolase 1); Microdochium bolleyi; 1.828e-46
XANPAGTX0501_001815-T1 not in cluster NA Non-DGE 0.85 85.35372 457 IPR003961 Fibronectin type III;IPR007484 Peptidase M28;IPR036116 Fibronectin type III superfamily NA M28E Non-antimicrobial 3B3C; Crystal structure of the M180A mutant of the aminopeptidase from Vibrio proteolyticus in complex with leucine phosphonic acid; 2.769e-15 2ANP; Functional Glutamate 151 to Histidine mutant of the aminopeptidase from Aeromonas Proteolytica.; 2.769e-15 A0A5C3Q954; Peptide hydrolase (EC 3.4.-.-); Pterula gracilis; 3.334e-60 A0A0C9VRY9; Peptide hydrolase (EC 3.4.-.-); Sphaerobolus stellatus (strain SS14); 2.84e-59
XANPAGTX0501_002007-T1 not in cluster NA Non-DGE 0.61 71.28474 817 NA NA NA Non-antimicrobial 8IC1; endo-alpha-D-arabinanase EndoMA1 D51N mutant from Microbacterium arabinogalactanolyticum in complex with arabinooligosaccharides; 3.989e-10 NA A0A1W5CV57; Apple domain-containing protein; Lasallia pustulata; 8.633e-83 U1GB34; Apple domain-containing protein; Endocarpon pusillum (strain Z07020 / HMAS-L-300199) (Lichen-forming fungus); 8.167e-66
XANPAGTX0501_002144-T1 not in cluster NA Non-DGE 0.94 93.64874 886 IPR001764 Glycoside hydrolase, family 3, N-terminal;IPR002772 Glycoside hydrolase family 3 C-terminal domain;IPR013783 Immunoglobulin-like fold;IPR017853 Glycoside hydrolase superfamily;IPR019800 Glycoside hydrolase, family 3, active site;IPR026891 Fibronectin type III-like domain;IPR036881 Glycoside hydrolase family 3 C-terminal domain superfamily;IPR036962 Glycoside hydrolase, family 3, N-terminal domain superfamily GH3 NA Antimicrobial 5FJJ; Three-dimensional structures of two heavily N-glycosylated Aspergillus sp. Family GH3 beta-D-glucosidases; 0 4IIH; Crystal structure of beta-glucosidase 1 from Aspergillus aculeatus in complex with thiocellobiose; 0 A0A5N5CY28; beta-glucosidase (EC 3.2.1.21); Lasiodiplodia theobromae; 0 Q0CTD7; Probable beta-glucosidase A (EC 3.2.1.21) (Beta-D-glucoside glucohydrolase A) (Cellobiase A) (Gentiobiase A); Aspergillus terreus (strain NIH 2624 / FGSC A1156); 0
XANPAGTX0501_002316-T1 not in cluster NA Non-DGE 0.66 70.70526 538 NA NA NA Non-antimicrobial 4QRK; Crystal structure of a putative cell adhesion protein (CLOSPO_03726) from Clostridium sporogenes ATCC 15579 at 1.95 A resolution; 9.468e-06 NA A0A6A6Y9H6; Adhesin domain-containing protein; Mytilinidion resinicola; 6.364e-23 A0A4Z1NZS1; Adhesin domain-containing protein; Venturia nashicola; 7.993e-22
XANPAGTX0501_002376-T1 not in cluster NA Non-DGE 0.91 91.82710 822 IPR014870 Domain of unknown function DUF1793;IPR032514 Domain of unknown function DUF4965;IPR033433 Domain of unknown function DUF5127 NA NA Non-antimicrobial 5O0S; Crystal structure of txGH116 (beta-glucosidase from Thermoanaerobacterium xylolyticum) in complex with unreacted beta Cyclophellitol Cyclosulfate probe ME711; 8.68e-22 5FJS; Bacterial beta-glucosidase reveals the structural and functional basis of genetic defects in human glucocerebrosidase 2 (GBA2); 8.42e-19 A0A6A6GM90; Glutaminase A; Elsinoe ampelina; 0 A0A0U1LR85; UPF0202 protein; Talaromyces islandicus (Penicillium islandicum); 0
XANPAGTX0501_002396-T1 not in cluster NA Non-DGE 0.88 90.18261 440 IPR000834 Peptidase M14, carboxypeptidase A;IPR003146 Carboxypeptidase, activation peptide;IPR036990 Metallocarboxypeptidase-like, propeptide NA M14A Non-antimicrobial 4UF4; NA; 5.797e-45 5OM9; Crystal structure of the human CARBOXYPEPTIDASE A1 in complex with a thiirane mechanism-based inhibitor; 1.045e-44 A0A0M9VUM1; Metallocarboxypeptidase A; Escovopsis weberi; 1.996e-58 A0A430LPP9; Peptidase M14 carboxypeptidase A domain-containing protein; Fusarium euwallaceae; 4.187e-52
XANPAGTX0501_002406-T2 not in cluster NA Non-DGE 0.89 89.56079 819 IPR011050 Pectin lyase fold/virulence factor;IPR012334 Pectin lyase fold;IPR024535 Pectate lyase superfamily protein GH55 NA Non-antimicrobial 3EQN; Crystal structure of beta-1,3-glucanase from Phanerochaete chrysosporium (Lam55A); 2.544e-51 5M5Z; Chaetomium thermophilum beta-1-3-glucanase; 1.217e-50 A0A135LHY7; Pectin lyase fold/virulence factor; Penicillium patulum (Penicillium griseofulvum); 2.282e-81 A0A1V6PF20; Pectate lyase superfamily protein domain-containing protein; Penicillium decumbens; 5.583e-81
XANPAGTX0501_002409-T1 not in cluster NA Upregulated in lichen 0.5 67.14336 110 IPR001338 Hydrophobin NA NA Non-antimicrobial NA NA Q96VD0; Hydrophobin H1; Xanthoria parietina; 7.874e-10 B9DR15; Hydrophobin; Xanthoria sp. 1653(143.2); 1.102e-08
XANPAGTX0501_002636-T1 not in cluster NA Non-DGE 0.88 86.39282 639 IPR002642 Lysophospholipase, catalytic domain;IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase NA NA Non-antimicrobial 5IZ5; Human GIVD cytosolic phospholipase A2; 2.78e-16 5IZ5; Human GIVD cytosolic phospholipase A2; 2.31e-15 A0A229XYZ1; deleted; ; 1.222e-73 G3Y902; Lysophospholipase (EC 3.1.1.5); Aspergillus niger (strain ATCC 1015 / CBS 113.46 / FGSC A1144 / LSHB Ac4 / NCTC 3858a / NRRL 328 / USDA 3528.7); 4.446e-72
XANPAGTX0501_003126-T1 not in cluster NA Non-DGE 0.89 89.33528 428 IPR021047 Mannosyltransferase 1, CMT1 GT69 NA Antimicrobial NA NA C1GWU2; Polysaccharide export protein (CAP59); Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides brasiliensis); 6.287e-51 A0A6A6S4M6; Glycosyltransferase family 69 protein; Massarina eburnea CBS 473.64; 8.481e-49
XANPAGTX0501_003130-T1 not in cluster NA Non-DGE 0.71 88.51188 489 IPR000209 Peptidase S8/S53 domain;IPR010259 Peptidase S8 propeptide/proteinase inhibitor I9;IPR015500 Peptidase S8, subtilisin-related;IPR022398 Peptidase S8, subtilisin, His-active site;IPR023828 Peptidase S8, subtilisin, Ser-active site;IPR034193 Proteinase K-like catalytic domain;IPR036852 Peptidase S8/S53 domain superfamily;IPR037045 Peptidase S8 propeptide/proteinase inhibitor I9 superfamily NA S08A Non-antimicrobial 7A9F; Co-substituted Keggin silicotungstate with covalent bond to proteinase K; 3.576e-35 3F7M; Crystal structure of apo Cuticle-Degrading Protease (ver112) from Verticillium psalliotae; 4.509e-35 W9YTV7; Cerevisin; Capronia epimyces CBS 606.96; 2.537e-74 A0A0D2BNZ3; Subtilisin-like protease; Exophiala spinifera; 2.688e-74
XANPAGTX0501_003186-T1 not in cluster NA Upregulated in lichen 0.79 86.69064 188 NA NA NA Non-antimicrobial NA NA A0A3D8RZY1; Uncharacterized protein; Coleophoma cylindrospora; 2.059e-11 A0A094GHG2; AB hydrolase-1 domain-containing protein; Pseudogymnoascus sp. VKM F-4518 (FW-2643); 9.153e-10
XANPAGTX0501_003307-T1 not in cluster NA Non-DGE 0.68 80.35710 145 IPR036514 SGNH hydrolase superfamily NA NA Non-antimicrobial NA NA A0A6A6IIT9; SGNH hydrolase; Trematosphaeria pertusa; 1.693e-08 A0A478EAD9; SGNH hydrolase-type esterase domain-containing protein; Talaromyces pinophilus (Penicillium pinophilum); 4.656e-08
XANPAGTX0501_003434-T1 not in cluster NA Non-DGE 0.9 94.06456 283 IPR003154 S1/P1 nuclease;IPR008947 Phospholipase C/P1 nuclease domain superfamily NA NA Non-antimicrobial 5FBF; S1 nuclease from Aspergillus oryzae in complex with two molecules of 2’-deoxycytidine-5’-monophosphate; 7.177e-22 1AK0; P1 NUCLEASE IN COMPLEX WITH A SUBSTRATE ANALOG; 2.691e-21 A0A0C3Q6Y7; Uncharacterized protein; Tulasnella calospora MUT 4182; 1.914e-23 A0A2D3V2J1; Related to nuclease S1; Ramularia collo-cygni; 3.019e-23
XANPAGTX0501_003448-T1 not in cluster NA Upregulated in lichen 0.73 78.49583 187 NA NA NA Non-antimicrobial NA NA NA NA
XANPAGTX0501_003490-T1 not in cluster NA Non-DGE 0.72 85.74232 538 IPR001623 DnaJ domain;IPR011990 Tetratricopeptide-like helical domain superfamily;IPR013026 None;IPR019734 Tetratricopeptide repeat;IPR036869 Chaperone J-domain superfamily NA NA Antimicrobial NA NA A0A3M7I0K9; J domain-containing protein; Hortaea werneckii; 9.659e-38 A0A3M6XUH3; J domain-containing protein; Hortaea werneckii; 1.363e-37
XANPAGTX0501_003643-T1 not in cluster NA Non-DGE 0.51 64.64147 469 NA NA NA Below pLDDT threshold NA NA A0A1E1LJD6; Related to AGA1 A-agglutinin anchor subunit; Rhynchosporium agropyri; 9.086e-33 A0A0C3D8D2; Ribosomal protein s17; Oidiodendron maius (strain Zn); 4.987e-32
XANPAGTX0501_003851-T1 not in cluster NA Non-DGE 0.54 81.14339 304 NA NA NA Non-antimicrobial 1R0S; Crystal structure of ADP-ribosyl cyclase Glu179Ala mutant; 0.0001116 4XJT; Human CD38 complexed with inhibitor 2 [4-[(2,6-dimethylbenzyl)amino]-2-methylquinoline-8-carboxamide]; 0.000683 T0F6N0; Intein C-terminal splicing domain protein; Leptospira broomii serovar Hurstbridge str. 5399; 1.235e-07 A0A2D3W406; DUF637 domain-containing protein; Sulfurospirillum sp. UBA11407; 1.884e-07
XANPAGTX0501_003873-T1 not in cluster NA Upregulated in lichen 0.8 85.71939 245 IPR002053 Glycoside hydrolase, family 25;IPR017853 Glycoside hydrolase superfamily;IPR018077 Glycoside hydrolase, family 25 subgroup GH25 NA Non-antimicrobial 6ZMV; Structure of muramidase from Trichobolus zukalii; 5.817e-32 2X8R; The structure of a family GH25 lysozyme from Aspergillus fumigatus; 2.217e-28 A0A6I5H8T3; Hydrolase; Streptomyces sp. SID486; 3.001e-24 A0A6B1PIJ5; deleted; ; 5.997e-24
XANPAGTX0501_004034-T1 not in cluster NA Non-DGE 0.57 80.69364 143 NA NA NA Non-antimicrobial 8B2G; SH3-like domain from Penicillium virgatum muramidase; 0.0001431 NA B6QI84; MBL2-like secreted peptide, putative; Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333) (Penicillium marneffei); 1.238e-10 A0A094A8R6; Uncharacterized protein; Pseudogymnoascus sp. VKM F-3808; 2.517e-10
XANPAGTX0501_004329-T1 not in cluster NA Upregulated in lichen 0.73 82.24983 176 IPR020915 Uncharacterised protein family UPF0311 NA NA Non-antimicrobial 3G7G; Crystal structure of the protein with unknown function from Clostridium acetobutylicum ATCC 824; 1.897e-08 3G7G; Crystal structure of the protein with unknown function from Clostridium acetobutylicum ATCC 824; 3.326e-08 A0A6A5YFR6; Secreted protein NIS1; Lophiotrema nucula; 6.873e-14 A0A0D2EUD7; Dirigent protein; Exophiala xenobiotica; 8.375e-13
XANPAGTX0501_004437-T1 not in cluster NA Non-DGE 0.89 90.68023 304 NA NA NA Non-antimicrobial NA NA A0A364KRR8; Uncharacterized protein; Talaromyces amestolkiae; 5.796e-35 A0A6A6RRD5; Uncharacterized protein; Massarina eburnea CBS 473.64; 3.692e-33
XANPAGTX0501_004920-T1 not in cluster NA Non-DGE 0.8 78.62424 516 IPR019236 Phosphatidate phosphatase APP1, catalytic domain NA NA Non-antimicrobial NA NA A0A178CYH7; Phosphatidate phosphatase APP1 catalytic domain-containing protein; Fonsecaea nubica; 2.457e-67 A0A517LQY5; Phosphatidate phosphatase APP1 catalytic domain-containing protein; Venturia effusa; 2.939e-67
XANPAGTX0501_005061-T1 not in cluster NA Upregulated in lichen 0.77 82.27010 197 NA NA NA Non-antimicrobial NA NA A0A5N6L4G7; Late sexual development protein; Carpinus fangiana; 9.341e-11 J3SFR0; Later sexual development protein; Cordyceps militaris (Caterpillar fungus) (Clavaria militaris); 5.096e-10
XANPAGTX0501_005118-T1 not in cluster NA Upregulated in culture 0.81 90.23024 206 NA NA NA Antimicrobial 4BK7; Crystal Structure of a variant of the Major Birch Pollen Allergen Bet v 1; 2.475e-05 2NS9; Crystal structure of protein APE2225 from Aeropyrum pernix K1, Pfam COXG; 0.000252 A0A2T3A6X0; Uncharacterized protein; Coniella lustricola; 6.598e-21 A0A4Z0Y6Z7; Uncharacterized protein; Xylaria hypoxylon; 6.014e-20
XANPAGTX0501_005540-T1 not in cluster NA Non-DGE 0.81 81.65689 601 IPR021102 Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase A NA NA Non-antimicrobial NA NA A0A1W5D9F6; Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase A; Lasallia pustulata; 1.304e-68 W9CIP8; Putative Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase A; Sclerotinia borealis (strain F-4128); 6.013e-65
XANPAGTX0501_005629-T1 not in cluster NA Upregulated in lichen 0.87 91.80710 420 IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily;IPR030395 Glycerophosphodiester phosphodiesterase domain NA NA Antimicrobial 1YDY; Crystal structure of periplasmic glycerophosphodiester phosphodiesterase from Escherichia coli; 6.608e-17 3L12; Crystal structure of Putative glycerophosphoryl diester phosphodiesterase (YP_165505.1) from Silicibacter pomeroyi DSS-3 at 1.60 A resolution; 3.272e-13 A0A0B8P194; glycerophosphodiester phosphodiesterase (EC 3.1.4.46); Vibrio ishigakensis; 5.68e-55 A0A6T9Y4D2; glycerophosphodiester phosphodiesterase (EC 3.1.4.46); Alteromonas macleodii (Pseudoalteromonas macleodii); 9.083e-55
XANPAGTX0501_005656-T1 not in cluster NA Non-DGE 0.78 85.19818 231 IPR025331 Tuberculosis necrotizing toxin NA NA Non-antimicrobial 8PMR; NADase from Aspergillus fumigatus with mutated calcium binding motif (D219A/E220A); 1.141e-25 6YGF; NADase from Aspergillus fumigatus with trapped reaction products; 7.19e-25 A0A1J7J3X2; TNT domain-containing protein; Coniochaeta ligniaria NRRL 30616; 2.685e-28 S3C0L4; TNT domain-containing protein; Ophiostoma piceae (strain UAMH 11346) (Sap stain fungus); 3.73e-28
XANPAGTX0501_005892-T1 not in cluster NA Non-DGE 0.75 87.75533 182 IPR017850 Alkaline-phosphatase-like, core domain superfamily NA NA Non-antimicrobial NA NA A0A1V1TF11; Uncharacterized protein; Xylariales sp. No.14919; 1.838e-22 A0A439CRK1; alkaline phosphatase (EC 3.1.3.1); Xylaria grammica; 1.939e-20
XANPAGTX0501_006290-T1 not in cluster NA Non-DGE 0.81 90.83000 155 NA NA NA Non-antimicrobial NA NA W9YLS9; Uncharacterized protein; Capronia coronata CBS 617.96; 4.986e-21 A0A194VTQ5; Uncharacterized protein; Valsa mali; 1.01e-19
XANPAGTX0501_006382-T1 not in cluster NA Upregulated in lichen 0.89 90.74412 413 NA NA NA Antimicrobial 6FWG; Structure of an E333Q variant of the GH99 endo-alpha-mannanase from Bacteroides xylanisolvens in complex with tetramannoside yeast mannan fragment; 8.222e-17 6FWM; Structure of the GH99 endo-alpha-mannanase from Bacteroides xylanisolvens in complex with alpha-Glc-1,3-1,2-anhydro-mannose hydrolyzed by enzyme; 9.306e-17 A0A6A6SUE6; Uncharacterized protein; Lophiostoma macrostomum CBS 122681; 2.142e-59 A0A2P6MTX4; Xylosidase/arabinosidase; Planoprotostelium fungivorum; 1.281e-41
XANPAGTX0501_006534-T1 not in cluster NA Non-DGE 0.75 78.95544 417 IPR000782 FAS1 domain;IPR036378 FAS1 domain superfamily NA NA Non-antimicrobial 5NV6; Structure of human transforming growth factor beta-induced protein (TGFBIp).; 1.457e-17 7AS7; Crystal structure of the GCD-associated TGFBIp mutant R124H; 4.57e-17 A0A1W5D899; FAS1 domain; Lasallia pustulata; 1.098e-46 A0A165FZY9; FAS1 domain-containing protein; Xylona heveae (strain CBS 132557 / TC161); 1.199e-44
XANPAGTX0501_006631-T1 not in cluster NA Non-DGE 0.54 74.07682 258 IPR008659 Yeast cell wall synthesis Kre9/Knh1, C-terminal;IPR018466 Yeast cell wall synthesis Kre9/Knh1-like, N-terminal NA NA Non-antimicrobial NA NA A0A2I0S4R5; deleted; ; 4.603e-24 A0A0F4GR13; Uncharacterized protein; Zymoseptoria brevis; 2.21e-23
XANPAGTX0501_006635-T1 not in cluster NA Non-DGE 0.65 70.70920 213 NA NA NA Non-antimicrobial NA NA A0A5M8PRM9; Uncharacterized protein; Lasallia pustulata; 2.628e-15 A0A1W5D8P3; Uncharacterized protein; Lasallia pustulata; 8.396e-13
XANPAGTX0501_006937-T1 not in cluster NA Non-DGE 0.64 60.82756 356 NA NA NA Below pLDDT threshold NA NA A0A4S8QVN8; Uncharacterized protein; Botrytis galanthina; 2.439e-10 W9CAJ0; Uncharacterized protein; Sclerotinia borealis (strain F-4128); 3.978e-09
XANPAGTX0501_006958-T1 not in cluster NA Non-DGE 0.82 85.80254 535 IPR003137 PA domain;IPR007484 Peptidase M28;IPR041756 Peptidase M28, SGAP-like NA M28A Antimicrobial 8AC9; Structure of Pseudomonas aeruginosa aminopeptidase, PaAP_T; 5.269e-51 8ACG; Structure of Pseudomonas aeruginosa aminopeptidase, PaAP_T E340A mutant; 1.883e-49 A0A6A6S275; Peptide hydrolase (EC 3.4.-.-); Massarina eburnea CBS 473.64; 4.081e-70 A0A6A6PEK6; Peptide hydrolase (EC 3.4.-.-); Lineolata rhizophorae; 2.051e-66
XANPAGTX0501_007039-T1 not in cluster NA Non-DGE 0.51 70.60086 278 NA NA NA Non-antimicrobial 6X4T; Crystal structure of ICOS-L in complex with Prezalumab and VNAR domain; 0.0001918 NA A0A3M0WE15; Uncharacterized protein; Chaetothyriales sp. CBS 134920; 6.04e-23 A0A3M7MWN4; Uncharacterized protein; Chaetothyriales sp. CBS 132003; 6.399e-23
XANPAGTX0501_007093-T2 not in cluster NA Non-DGE 0.84 85.95366 369 IPR013126 Heat shock protein 70 family NA NA Non-antimicrobial 5OBV; Mycoplasma genitalium DnaK deletion mutant lacking SBDalpha in complex with ADP and Pi.; 1.644e-12 6CZ1; Crystal structure of ATPase domain of Human GRP78 bound to Ver155008; 1.644e-12 C5FXE3; Uncharacterized protein; Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis); 2.668e-33 A0A395HEJ5; Aminoglycoside phosphotransferase domain-containing protein; Aspergillus ibericus CBS 121593; 3.088e-27
XANPAGTX0501_007316-T1 not in cluster NA Non-DGE 0.91 94.15843 388 IPR008183 Aldose 1-/Glucose-6-phosphate 1-epimerase;IPR011013 Galactose mutarotase-like domain superfamily;IPR014718 Glycoside hydrolase-type carbohydrate-binding NA NA Non-antimicrobial 1LUR; Crystal Structure of the GalM/aldose Epimerase Homologue from C. elegans, Northeast Structural Genomics Target WR66; 5.745e-31 1SO0; Crystal structure of human galactose mutarotase complexed with galactose; 1.329e-30 A0A1W5D5J2; Aldose 1-epimerase; Lasallia pustulata; 7.406e-65 A0A150V8R4; Aldose 1-epimerase; Acidomyces richmondensis BFW; 1.806e-58
XANPAGTX0501_007388-T1 not in cluster NA Upregulated in culture 0.89 88.42941 563 IPR002372 Pyrrolo-quinoline quinone repeat;IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily;IPR015943 WD40/YVTN repeat-like-containing domain superfamily;IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat NA NA Antimicrobial 7CDL; holo-methanol dehydrogenase (MDH) with Cys131-Cys132 reduced from Methylococcus capsulatus (Bath); 3.738e-20 2D0V; Crystal structure of methanol dehydrogenase from Hyphomicrobium denitrificans; 2.31e-19 T0KY48; PQQ enzyme repeat protein; Colletotrichum gloeosporioides (strain Cg-14) (Anthracnose fungus) (Glomerella cingulata); 5.883e-64 A0A1Y1ZWW9; Quinon protein alcohol dehydrogenase-like superfamily; Clohesyomyces aquaticus; 2.844e-48
XANPAGTX0501_007437-T1 not in cluster NA Non-DGE 0.55 63.38476 292 NA NA NA Below pLDDT threshold NA NA A0A7C8IH86; Uncharacterized protein; Massariosphaeria phaeospora; 1.818e-13 E3RDR6; Uncharacterized protein; Pyrenophora teres f. teres (strain 0-1) (Barley net blotch fungus) (Drechslera teres f. teres); 8.054e-13
XANPAGTX0501_007655-T1 not in cluster NA Upregulated in lichen 0.71 73.85991 466 IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily NA NA Non-antimicrobial 2ISD; PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C-DELTA1 FROM RAT; 0.00091 NA A0A3E2H320; PLC-like phosphodiesterase; Scytalidium lignicola (Hyphomycete); 1.563e-51 A0A420HWP5; Putative secreted protein; Golovinomyces cichoracearum; 2.911e-51
XANPAGTX0501_007769-T1 not in cluster NA Non-DGE 0.75 79.42492 626 IPR020067 Frizzled domain;IPR024338 Stretch-activated cation channel Mid1/Calcium influx-promoting protein Ehs1 NA NA Antimicrobial NA NA A0A5M8PTI9; Calcium channel MID1; Lasallia pustulata; 1.168e-57 A0A2S4PQ51; FZ domain-containing protein; Erysiphe pulchra; 2.473e-53
XANPAGTX0501_008252-T1 not in cluster NA Non-DGE 0.82 86.45067 404 IPR032675 Leucine-rich repeat domain superfamily NA NA Non-antimicrobial NA NA C5FEL3; Ecm33; Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis); 5.036e-25 F0U581; GPI-anchored cell wall organization protein; Ajellomyces capsulatus (strain H88) (Darling’s disease fungus) (Histoplasma capsulatum); 1.644e-22
XANPAGTX0501_008270-T1 not in cluster NA Upregulated in lichen 0.74 77.95650 200 NA NA NA Non-antimicrobial NA NA A0A318ZGC2; Uncharacterized protein; Aspergillus saccharolyticus JOP 1030-1; 1.402e-09 A0A2K9YDH4; Uncharacterized protein; Cladonia uncialis subsp. uncialis; 1.744e-09
XANPAGTX0501_008637-T1 not in cluster NA Non-DGE 0.61 68.18693 476 NA NA NA Non-antimicrobial NA NA C4JJA1; Uncharacterized protein; Uncinocarpus reesii (strain UAMH 1704); 2.814e-36 S8B6S8; Uncharacterized protein; Penicillium oxalicum (strain 114-2 / CGMCC 5302) (Penicillium decumbens); 4.968e-36
XANPAGTX0501_008763-T1 not in cluster NA Non-DGE 0.86 88.38733 389 IPR036278 Sialidase superfamily GH93 NA Non-antimicrobial 2W5N; Native structure of the GH93 alpha-L-arabinofuranosidase of Fusarium graminearum; 2.388e-14 3A71; High resolution structure of Penicillium chrysogenum alpha-L-arabinanase; 2.909e-14 A0A139I7Q9; Sialidase domain-containing protein; Pseudocercospora musae; 3.798e-37 Q2HC91; Sialidase domain-containing protein; Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus); 8.043e-29
XANPAGTX0501_008858-T1 not in cluster NA Non-DGE 0.9 92.51140 572 IPR000101 Gamma-glutamyltranspeptidase;IPR029055 Nucleophile aminohydrolases, N-terminal;IPR043137 Gamma-glutamyltranspeptidase, small subunit;IPR043138 Gamma-glutamyltranspeptidase, large subunit, C-terminal domain NA T03 Non-antimicrobial 2E0W; T391A precursor mutant protein of gamma-Glutamyltranspeptidase from Escherichia coli; 1.118e-43 4Y23; Crystal structure of T399A precursor mutant protein of gamma-glutamyl transpeptidase from Bacillus licheniformis; 2.683e-41 A0A0F4YDN3; Glutathione hydrolase (EC 2.3.2.2) (EC 3.4.19.13) (Gamma-glutamyltransferase) (Gamma-glutamyltranspeptidase); Rasamsonia emersonii CBS 393.64; 6.968e-83 A0A2I2GMW9; Zn(2)-C6 fungal-type domain-containing protein; Aspergillus steynii IBT 23096; 4.193e-81
XANPAGTX0501_009170-T1 not in cluster NA Upregulated in culture 0.72 81.22039 282 IPR000334 Glycoside hydrolase, family 45;IPR036908 RlpA-like domain superfamily GH45 NA Antimicrobial 4ENG; STRUCTURE OF ENDOGLUCANASE V CELLOHEXAOSE COMPLEX; 3.143e-29 6MVI; Apo Cel45A from Neurospora crassa OR74A; 1.277e-28 A0A2B7YD39; Cellulase (EC 3.2.1.4); Helicocarpus griseus UAMH5409; 1.565e-31 A0A074VM44; Cellulase (EC 3.2.1.4); Aureobasidium melanogenum CBS 110374; 1.565e-31
XANPAGTX0501_009211-T1 not in cluster NA Non-DGE 0.91 92.80117 707 IPR003137 PA domain;IPR007365 Transferrin receptor-like, dimerisation domain;IPR007484 Peptidase M28;IPR036757 Transferrin receptor-like, dimerisation domain superfamily NA M28B Non-antimicrobial 4P44; X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with a phosphoramidate inhibitor JRB-4-81; 1.814e-68 4P4D; X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with a phosphoramidate inhibitor MP1C; 2.417e-68 A0A7C8MSS2; Heterokaryon incompatibility domain-containing protein; Xylaria multiplex; 0 A0A135UQD7; PA domain-containing protein; Colletotrichum nymphaeae SA-01; 0
XANPAGTX0501_009293-T1 not in cluster NA Non-DGE 0.69 84.51065 107 NA NA NA Antimicrobial NA NA A0A1L9RFQ7; Uncharacterized protein; Aspergillus wentii DTO 134E9; 2.072e-08 A0A017S360; Uncharacterized protein; Aspergillus ruber (strain CBS 135680); 4.85e-08
XANPAGTX0501_009521-T1 not in cluster NA Non-DGE 0.92 93.58860 979 IPR000322 Glycoside hydrolase family 31;IPR011013 Galactose mutarotase-like domain superfamily;IPR013780 Glycosyl hydrolase, all-beta;IPR017853 Glycoside hydrolase superfamily;IPR025887 Glycoside hydrolase family 31, N-terminal domain;IPR030458 Glycosyl hydrolases family 31, active site;IPR033403 Domain of unknown function DUF5110 GH31 NA Non-antimicrobial 5DL0; Crystal structure of glucosidase II alpha subunit (Glc1Man2-bound from); 0 5DKX; Crystal structure of glucosidase II alpha subunit (Tris-bound from); 0 A0A4P6XXT6; Glucosidase II subunit alpha; Metschnikowia aff. pulcherrima; 0 A2DBB0; Glucosidase II subunit alpha; Trichomonas vaginalis (strain ATCC PRA-98 / G3); 6.364e-101
XANPAGTX0501_009694-T1 not in cluster NA Non-DGE 0.73 74.51758 702 IPR017853 Glycoside hydrolase superfamily;IPR039514 Endo-beta-1,6-galactanase-like GH30 NA Antimicrobial 7N6O; The crystal structure of the GH30 subfamily 10 enzyme, AcXbh30A from Acetivibrio clariflavus in complex with xylobiose; 3.122e-31 5CXP; X-ray crystallographic protein structure of the glycoside hydrolase family 30 subfamily 8 xylanase, Xyn30A, from Clostridium acetobutylicum; 1.856e-24 A0A6J3MFN7; Glycoside hydrolase family 30 protein; Dissoconium aciculare CBS 342.82; 1.804e-62 B0DQ00; Glycoside hydrolase family 5 protein; Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686) (Bicoloured deceiver) (Laccaria laccata var. bicolor); 1.794e-61
XANPAGTX0501_009729-T1 not in cluster NA Non-DGE 0.77 82.65681 191 NA GH134 NA Non-antimicrobial 5JTS; Structure of a beta-1,4-mannanase, SsGH134.; 3.307e-09 5XUL; Complex structure (RmMan134A-M6).; 1.15e-08 A0A1L9SZB2; Uncharacterized protein; Aspergillus sydowii CBS 593.65; 1.913e-09 A0A1B8GLK5; Uncharacterized protein; Pseudogymnoascus verrucosus; 5.906e-09
XANPAGTX0501_009761-T1 not in cluster NA Upregulated in culture 0.73 84.12986 211 IPR001283 Cysteine-rich secretory protein-related;IPR014044 CAP domain;IPR018244 Allergen V5/Tpx-1-related, conserved site;IPR034120 None;IPR035940 CAP superfamily NA NA Non-antimicrobial 5JYS; Pry1 CAP domain; 2.82e-16 1SMB; Crystal Structure of Golgi-Associated PR-1 protein; 4.65e-13 A0A1B8GSL1; SCP domain-containing protein; Pseudogymnoascus verrucosus; 2.459e-23 A0A436ZUH8; SCP domain-containing protein; Arthrobotrys flagrans; 8.976e-21
XANPAGTX0501_009880-T1 not in cluster NA Non-DGE 0.69 75.76424 229 NA NA NA Antimicrobial NA NA U4L2B3; Uncharacterized protein; Pyronema omphalodes (strain CBS 100304) (Pyronema confluens); 1.082e-19 A0A1Y2LYF1; SRCR domain-containing protein; Epicoccum nigrum (Soil fungus) (Epicoccum purpurascens); 3.713e-17
XANPAGTX0501_009902-T1 not in cluster NA Upregulated in culture 0.81 82.82577 291 IPR001148 Alpha carbonic anhydrase domain;IPR036398 Alpha carbonic anhydrase domain superfamily;IPR041891 Carbonic anhydrase, prokaryotic-like NA NA Non-antimicrobial 3F7U; Crystal Structure of soluble domain of CA4 in complex with small molecule.; 1.063e-15 7POM; Three dimensional structure of human carbonic anhydrase IX in complex with sulfonamide; 1.13e-15 R7YXY8; Alpha-carbonic anhydrase domain-containing protein; Coniosporium apollinis (strain CBS 100218) (Rock-inhabiting black yeast); 3.485e-38 A0A3M2SB97; Alpha-carbonic anhydrase domain-containing protein; Fusarium kuroshium; 1.106e-37
XANPAGTX0501_009945-T1 not in cluster NA Non-DGE 0.64 64.67120 259 NA NA NA Below pLDDT threshold NA NA Q2GRQ4; Uncharacterized protein; Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus); 7.202e-05 NA
XANPAGTX0501_009972-T1 not in cluster NA Upregulated in lichen 0.85 89.22651 656 IPR000209 Peptidase S8/S53 domain;IPR015366 Peptidase S53, activation domain;IPR030400 Sedolisin domain;IPR036852 Peptidase S8/S53 domain superfamily NA S53 Antimicrobial 3EE6; Crystal Structure Analysis of Tripeptidyl peptidase -I; 1.051e-44 3EDY; Crystal Structure of the Precursor Form of Human Tripeptidyl-Peptidase 1; 1.486e-44 A0A5C3NB46; Subtilisin-like protein; Heliocybe sulcata; 2.6e-89 S8EJ40; Peptidase S53 domain-containing protein; Fomitopsis schrenkii (Brown rot fungus); 1.85e-72
XANPAGTX0501_010027-T1 not in cluster NA Upregulated in lichen 0.54 56.30980 250 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_010044-T1 not in cluster NA Upregulated in lichen 0.67 84.62511 229 IPR002937 Amine oxidase;IPR036188 FAD/NAD(P)-binding domain superfamily NA NA Non-antimicrobial 3KU9; X-ray structure of the mutant lys300met of polyamine oxidase from zea mays in complex with spermine; 2.898e-08 1YY5; Crystal structure of Fms1, a polyamine oxidase from Yeast; 9.663e-05 A0A1Y1ZCU9; Amine oxidase domain-containing protein; Clohesyomyces aquaticus; 2.895e-23 A0A6A6IC26; Amine oxidase (EC 1.4.3.-); Trematosphaeria pertusa; 1.23e-20
XANPAGTX0501_010179-T1 not in cluster NA Non-DGE 0.7 88.40682 773 IPR002509 NodB homology domain;IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel CE4 NA Antimicrobial 7BLY; Structure of the chitin deacetylase AngCDA from Aspergillus niger; 5.956e-15 2Y8U; A. nidulans chitin deacetylase; 5.66e-14 A0A395IMC3; NodB homology domain-containing protein; Monilinia fructigena; 1.698e-64 A0A7H8RGX4; RNA helicase (EC 3.6.4.13); Talaromyces rugulosus; 8.317e-51
XANPAGTX0501_010191-T1 not in cluster NA Upregulated in culture 0.81 88.59765 221 IPR000675 Cutinase/acetylxylan esterase;IPR011150 Cutinase, monofunctional;IPR029058 Alpha/Beta hydrolase fold CE5 NA Antimicrobial 4PSD; Structure of Trichoderma reesei cutinase native form.; 1.768e-17 3DEA; Glomerella cingulata PETFP-cutinase complex; 8.199e-13 A0A6A6U7K6; Cutinase (EC 3.1.1.74); Microthyrium microscopicum; 4.921e-20 A0A3M7EGU2; Cutinase (EC 3.1.1.74); Hortaea werneckii; 7.466e-18
XANPAGTX0501_010250-T1 not in cluster NA Upregulated in lichen 0.78 81.44745 141 NA NA NA Non-antimicrobial NA NA A0A395I706; Ig-like domain-containing protein; Aspergillus homomorphus (strain CBS 101889); 5.921e-15 A0A6A5RM64; Ig-like domain-containing protein; Didymella exigua CBS 183.55; 1.416e-14
XANPAGTX0501_010326-T1 not in cluster NA Non-DGE 0.64 82.37849 146 IPR000172 Glucose-methanol-choline oxidoreductase, N-terminal;IPR036188 FAD/NAD(P)-binding domain superfamily NA NA Non-antimicrobial 8BXL; Patulin Synthase from Penicillium expansum; 3.518e-11 4H7U; Crystal structure of pyranose dehydrogenase from Agaricus meleagris, wildtype; 1.628e-08 C9SEJ0; Choline dehydrogenase; Verticillium alfalfae (strain VaMs.102 / ATCC MYA-4576 / FGSC 10136) (Verticillium wilt of alfalfa) (Verticillium albo-atrum); 3.414e-14 A0A0C4EB00; Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein; Magnaporthiopsis poae (strain ATCC 64411 / 73-15) (Kentucky bluegrass fungus) (Magnaporthe poae); 7.537e-14
XANPAGTX0501_010370-T1 not in cluster NA Upregulated in lichen 0.53 63.13854 308 IPR003609 PAN/Apple domain NA NA Below pLDDT threshold NA NA A0A2T2NYB4; Apple domain-containing protein; Corynespora cassiicola Philippines; 2.64e-21 A0A6A6Y414; Apple domain-containing protein; Mytilinidion resinicola; 2.453e-20
XANPAGTX0501_010426-T1 not in cluster NA Non-DGE 0.87 89.27199 337 IPR018170 Aldo/keto reductase, conserved site;IPR020471 Aldo-keto reductase;IPR023210 NADP-dependent oxidoreductase domain;IPR036812 NADP-dependent oxidoreductase domain superfamily NA NA Non-antimicrobial 5HNT; Crystal Structure of AKR1C3 complexed with CAPE; 2.98e-30 4FAL; Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 in complex with 3-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-methylbenzamide (80); 1.409e-28 A0A2V1E8K6; Aldo/keto reductase; Periconia macrospinosa; 1.788e-43 A0A6A5TPB9; Aldo/keto reductase; Byssothecium circinans; 3.235e-43
XANPAGTX0501_010590-T1 not in cluster NA Non-DGE 0.63 86.96828 406 IPR001568 Ribonuclease T2-like;IPR018188 Ribonuclease T2, His active site 1;IPR033130 Ribonuclease T2, His active site 2;IPR033697 Ribonuclease T2, eukaryotic;IPR036430 Ribonuclease T2-like superfamily NA NA Antimicrobial 3TBJ; The 1.7A crystal structure of Actibind a T2 ribonucleases as antitumorigenic agents; 8.715e-30 1BOL; THE CRYSTAL STRUCTURE OF RIBONUCLEASE RH FROM RHIZOPUS NIVEUS AT 2.0 A RESOLUTION; 1.534e-22 A0A1E1KC66; Related to ribonucleases; Rhynchosporium agropyri; 6.326e-52 A0A179TXI2; deleted; ; 2.654e-48
XANPAGTX0501_010682-T1 not in cluster NA Upregulated in lichen 0.5 56.12104 251 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_000013-T1 pTM below threshold NA Non-DGE 0.38 61.66691 256 NA NA NA Below pLDDT threshold NA NA C1GWS1; Extracellular membrane protein CFEM domain-containing protein; Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides brasiliensis); 1.568e-08 A0A1J9QV12; Extracellular membrane protein CFEM domain-containing protein; Blastomyces percursus; 2.619e-08
XANPAGTX0501_000052-T1 pTM below threshold NA Non-DGE 0.38 42.72020 205 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_000098-T1 pTM below threshold NA Non-DGE 0.28 35.07247 170 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_000162-T1 pTM below threshold NA Upregulated in lichen 0.14 48.05267 105 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_000212-T1 pTM below threshold NA Non-DGE 0.22 34.04358 265 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_000271-T1 pTM below threshold NA Non-DGE 0.22 35.77524 368 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_000324-T1 pTM below threshold NA Non-DGE 0.43 47.81232 298 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_000327-T1 pTM below threshold NA Non-DGE 0.32 34.56706 194 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_000401-T1 pTM below threshold NA Upregulated in culture 0.32 40.85944 216 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_000434-T1 pTM below threshold NA Upregulated in lichen 0.25 29.38005 588 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_000470-T1 pTM below threshold NA Non-DGE 0.13 45.71574 216 IPR031452 Protein Kre1 NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_000606-T1 pTM below threshold NA Upregulated in lichen 0.19 29.36423 267 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_000609-T1 pTM below threshold NA Upregulated in lichen 0.35 44.32490 149 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_000630-T1 pTM below threshold NA Non-DGE 0.38 58.03000 175 IPR008427 Extracellular membrane protein, CFEM domain NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_000639-T1 pTM below threshold NA Non-DGE 0.29 59.62101 119 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_000655-T1 pTM below threshold NA Upregulated in lichen 0.43 40.92976 210 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_000697-T1 pTM below threshold NA Upregulated in lichen 0.23 40.31839 224 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_000700-T1 pTM below threshold NA Non-DGE 0.48 53.36772 346 IPR036908 RlpA-like domain superfamily NA NA Below pLDDT threshold NA NA A0A4S9S5J9; Expansin-like EG45 domain-containing protein; Aureobasidium pullulans (Black yeast) (Pullularia pullulans); 1.557e-08 A0A178CMY3; deleted; ; 1.304e-07
XANPAGTX0501_000737-T1 pTM below threshold NA Upregulated in lichen 0.24 32.97850 341 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_000813-T1 pTM below threshold NA Non-DGE 0.38 45.56127 197 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_000953-T1 pTM below threshold NA Non-DGE 0.18 28.39448 201 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_001001-T1 pTM below threshold NA Non-DGE 0.2 57.35556 99 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_001042-T1 pTM below threshold NA Non-DGE 0.31 42.27669 142 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_001063-T1 pTM below threshold NA Upregulated in lichen 0.19 56.66084 131 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_001103-T1 pTM below threshold NA Non-DGE 0.16 51.99290 107 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_001136-T1 pTM below threshold NA Non-DGE 0.38 48.69567 1002 IPR002889 Carbohydrate-binding WSC AA2, AA5 NA Below pLDDT threshold 5FWW; Wnt modulator Kremen in complex with DKK1 (CRD2) and LRP6 (PE3PE4); 1.155e-06 6SNW; Structure of Coxsackievirus A10 complexed with its receptor KREMEN1; 1.572e-06 A0A1J9R4V4; Wsc-domain-containing protein; Diplodia corticola; 2.932e-19 A0A3M7A6V9; WSC domain-containing protein; Hortaea werneckii; 1.006e-18
XANPAGTX0501_001183-T1 pTM below threshold NA Upregulated in lichen 0.44 47.35611 126 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_001304-T1 pTM below threshold NA Upregulated in lichen 0.39 66.09179 78 NA NA NA Non-antimicrobial NA NA NA NA
XANPAGTX0501_001461-T1 pTM below threshold NA Non-DGE 0.28 36.83783 157 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_001550-T1 pTM below threshold NA Non-DGE 0.44 59.11496 276 IPR002889 Carbohydrate-binding WSC AA2, AA5 NA Below pLDDT threshold 6SNW; Structure of Coxsackievirus A10 complexed with its receptor KREMEN1; 2.564e-08 5FWU; Wnt modulator Kremen crystal form II at 2.8A; 3.73e-08 A0A2J6PEI4; Copper radical oxidase; Hyaloscypha hepaticicola; 4.812e-10 A0A072PVC9; WSC domain-containing protein; Exophiala aquamarina CBS 119918; 5.804e-10
XANPAGTX0501_001708-T1 pTM below threshold NA Upregulated in lichen 0.32 35.93536 222 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_001709-T1 pTM below threshold NA Non-DGE 0.31 37.15931 216 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_001849-T1 pTM below threshold NA Non-DGE 0.39 41.61976 207 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_001919-T1 pTM below threshold NA Upregulated in lichen 0.26 35.33512 203 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_001935-T1 pTM below threshold NA Upregulated in lichen 0.15 47.83888 170 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_002013-T1 pTM below threshold NA Non-DGE 0.16 49.99292 171 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_002041-T1 pTM below threshold NA Upregulated in lichen 0.32 38.90838 111 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_002086-T1 pTM below threshold NA Non-DGE 0.39 58.80412 204 IPR008427 Extracellular membrane protein, CFEM domain NA NA Below pLDDT threshold NA NA A0A2V1B9P3; Extracellular membrane protein CFEM domain-containing protein; Cadophora sp. DSE1049; 4.966e-06 A0A3D8QQ47; Extracellular membrane protein CFEM domain-containing protein; Coleophoma crateriformis; 3.307e-05
XANPAGTX0501_002121-T1 pTM below threshold NA Non-DGE 0.21 30.50148 244 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_002186-T1 pTM below threshold NA Upregulated in lichen 0.17 44.08050 397 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_002220-T1 pTM below threshold NA Non-DGE 0.43 50.26500 1168 IPR001223 Glycoside hydrolase family 18, catalytic domain;IPR001579 Glycosyl hydrolases family 18 (GH18) active site;IPR017853 Glycoside hydrolase superfamily GH18 NA Below pLDDT threshold 4TX6; AfChiA1 in complex with compound 1; 3.579e-40 2XUC; Natural product-guided discovery of a fungal chitinase inhibitor; 9.1e-36 A0A5M8PFI4; chitinase (EC 3.2.1.14); Lasallia pustulata; 2.869e-51 A0A2I0RWZ2; deleted; ; 2.694e-41
XANPAGTX0501_002264-T1 pTM below threshold NA Non-DGE 0.45 54.44478 182 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_002336-T1 pTM below threshold NA Non-DGE 0.24 48.11919 236 IPR000420 Yeast PIR protein repeat NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_002412-T1 pTM below threshold NA Upregulated in lichen 0.47 46.08050 440 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_002412-T2 pTM below threshold NA Upregulated in lichen 0.49 47.55088 431 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_002423-T1 pTM below threshold NA Non-DGE 0.45 67.76805 77 NA NA NA Non-antimicrobial NA NA NA NA
XANPAGTX0501_002446-T1 pTM below threshold NA Upregulated in lichen 0.28 52.93857 189 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_002482-T1 pTM below threshold NA Non-DGE 0.26 30.07165 248 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_002502-T1 pTM below threshold NA Non-DGE 0.45 44.87958 286 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_002514-T1 pTM below threshold NA Upregulated in lichen 0.2 56.13142 106 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_002565-T1 pTM below threshold NA Upregulated in lichen 0.29 48.51197 147 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_002660-T1 pTM below threshold NA Non-DGE 0.32 50.18997 309 IPR000420 Yeast PIR protein repeat NA NA Below pLDDT threshold NA NA A0A2K0WBY6; Uncharacterized protein; Gibberella nygamai (Bean root rot disease fungus) (Fusarium nygamai); 2.916e-05 A0A0F2MMU3; Uncharacterized protein; Sporothrix schenckii 1099-18; 4.904e-05
XANPAGTX0501_002665-T1 pTM below threshold NA Upregulated in lichen 0.35 40.79893 280 IPR024079 Metallopeptidase, catalytic domain superfamily NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_002697-T1 pTM below threshold NA Non-DGE 0.38 54.53519 154 NA GH128 NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_002844-T1 pTM below threshold NA Non-DGE 0.42 60.30492 177 IPR008427 Extracellular membrane protein, CFEM domain NA NA Below pLDDT threshold NA NA A0A6A6WBS8; Extracellular membrane protein CFEM domain-containing protein; Pseudovirgaria hyperparasitica; 7.371e-05 A0A4S8UDR1; WSC domain-containing protein; Aureobasidium pullulans (Black yeast) (Pullularia pullulans); 0.0002121
XANPAGTX0501_003040-T1 pTM below threshold NA Non-DGE 0.35 55.21358 296 IPR008427 Extracellular membrane protein, CFEM domain NA NA Below pLDDT threshold NA NA A0A178CLW4; Extracellular membrane protein CFEM domain-containing protein; Fonsecaea nubica; 2.395e-05 A0A0D2AVK1; Extracellular membrane protein CFEM domain-containing protein; Exophiala spinifera; 0.0001056
XANPAGTX0501_003231-T1 pTM below threshold NA Non-DGE 0.37 46.96308 211 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_003232-T1 pTM below threshold NA Non-DGE 0.19 42.98057 105 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_003233-T1 pTM below threshold NA Non-DGE 0.37 47.58521 192 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_003270-T1 pTM below threshold NA Upregulated in lichen 0.23 36.12173 231 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_003314-T1 pTM below threshold NA Non-DGE 0.27 48.61361 97 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_003361-T1 pTM below threshold NA Upregulated in lichen 0.44 51.78166 500 NA NA NA Below pLDDT threshold NA NA A0A6H0XNU9; Uncharacterized protein; Peltaster fructicola; 1.513e-18 J3KK77; Uncharacterized protein; Coccidioides immitis (strain RS) (Valley fever fungus); 2.67e-18
XANPAGTX0501_003362-T1 pTM below threshold NA Non-DGE 0.19 31.78513 955 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_003435-T1 pTM below threshold NA Non-DGE 0.32 47.97649 606 NA NA NA Below pLDDT threshold NA NA A0A1W5DE84; glutathione transferase (EC 2.5.1.18); Lasallia pustulata; 3.128e-09 U4LRI5; Carbohydrate-binding module family 19 domain-containing protein; Pyronema omphalodes (strain CBS 100304) (Pyronema confluens); 1.09e-07
XANPAGTX0501_003436-T1 pTM below threshold NA Non-DGE 0.48 74.36984 190 NA NA NA Antimicrobial NA NA A0A1B8D8I3; Biotrophy-associated secreted protein 2; Pseudogymnoascus sp. 24MN13; 2.363e-19 A0A094CVI4; Biotrophy-associated secreted protein 2; Pseudogymnoascus sp. VKM F-4515 (FW-2607); 2.429e-18
XANPAGTX0501_003606-T1 pTM below threshold NA Upregulated in lichen 0.29 34.10482 197 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_003677-T1 pTM below threshold NA Non-DGE 0.27 30.55640 197 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_003679-T1 pTM below threshold NA Non-DGE 0.46 49.80288 560 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_003725-T1 pTM below threshold NA Non-DGE 0.25 48.07547 1001 NA NA NA Below pLDDT threshold NA NA A0A093ZSQ2; F-box domain-containing protein; Pseudogymnoascus sp. VKM F-3775; 9.192e-06 A0A6A5K0Q4; Uncharacterized protein; Decorospora gaudefroyi; 5.299e-05
XANPAGTX0501_003765-T1 pTM below threshold NA Upregulated in lichen 0.17 36.25006 350 IPR000420 Yeast PIR protein repeat NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_003766-T1 pTM below threshold NA Upregulated in lichen 0.35 47.00045 177 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_003769-T1 pTM below threshold NA Non-DGE 0.38 84.30392 51 NA NA NA Non-antimicrobial NA NA NA NA
XANPAGTX0501_003850-T1 pTM below threshold NA Upregulated in culture 0.29 38.25145 304 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_003863-T2 pTM below threshold NA Upregulated in culture 0.39 50.59582 340 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_003865-T1 pTM below threshold NA Non-DGE 0.24 32.08215 247 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_003880-T1 pTM below threshold NA Non-DGE 0.41 54.98441 281 NA NA NA Below pLDDT threshold NA NA A0A6A6HBS6; AA1-like domain-containing protein; Viridothelium virens; 0.000714 NA
XANPAGTX0501_003978-T1 pTM below threshold NA Non-DGE 0.16 46.38479 240 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_003988-T1 pTM below threshold NA Non-DGE 0.48 52.03327 844 IPR008427 Extracellular membrane protein, CFEM domain NA NA Below pLDDT threshold NA NA A0A6A6HF69; Extracellular membrane protein CFEM domain-containing protein; Viridothelium virens; 4.525e-25 A0A0A1TKI7; Putative Beta-1,3-endoglucanase; [Torrubiella] hemipterigena; 4.406e-23
XANPAGTX0501_004023-T1 pTM below threshold NA Non-DGE 0.23 40.82680 222 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_004085-T1 pTM below threshold NA Non-DGE 0.27 34.75723 697 IPR000420 Yeast PIR protein repeat NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_004226-T1 pTM below threshold NA Non-DGE 0.33 48.76878 1218 NA NA NA Below pLDDT threshold NA NA A0A0F7U4N9; Uncharacterized protein; Penicillium brasilianum; 1.716e-15 A0A4Z0Z4R1; Uncharacterized protein; Xylaria hypoxylon; 2.608e-10
XANPAGTX0501_004309-T1 pTM below threshold NA Upregulated in lichen 0.28 55.95350 80 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_004507-T1 pTM below threshold NA Non-DGE 0.49 60.31919 295 IPR008427 Extracellular membrane protein, CFEM domain NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_004636-T1 pTM below threshold NA Non-DGE 0.26 41.79605 693 NA NA NA Below pLDDT threshold NA NA A0A6G1HAL2; Apple domain-containing protein; Aulographum hederae CBS 113979; 8.048e-07 A0A4V4K3D9; feruloyl esterase (EC 3.1.1.73); Aureobasidium pullulans (Black yeast) (Pullularia pullulans); 1.935e-06
XANPAGTX0501_004671-T1 pTM below threshold NA Non-DGE 0.33 40.73679 187 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_004880-T1 pTM below threshold NA Upregulated in lichen 0.2 46.83578 199 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_004881-T1 pTM below threshold NA Upregulated in lichen 0.17 31.09336 447 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_004930-T1 pTM below threshold NA Upregulated in lichen 0.19 42.19248 137 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_004931-T1 pTM below threshold NA Non-DGE 0.25 56.26977 214 NA NA NA Below pLDDT threshold NA NA M3D3T5; Uncharacterized protein; Sphaerulina musiva (strain SO2202) (Poplar stem canker fungus) (Septoria musiva); 0.0001561 A0A1P8YXY7; Uncharacterized protein; Passalora fulva (Tomato leaf mold) (Cladosporium fulvum); 0.0002854
XANPAGTX0501_004978-T1 pTM below threshold NA Upregulated in lichen 0.18 38.53014 212 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_005046-T1 pTM below threshold NA Non-DGE 0.3 33.33182 231 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_005093-T1 pTM below threshold NA Non-DGE 0.43 73.20231 117 IPR011024 Gamma-crystallin-like NA NA Non-antimicrobial NA NA A0A135TVW9; Uncharacterized protein; Colletotrichum nymphaeae SA-01; 4.513e-05 A0A2T2PBH5; Beta/gamma crystallin ‘Greek key’ domain-containing protein; Corynespora cassiicola Philippines; 0.0001914
XANPAGTX0501_005317-T1 pTM below threshold NA Upregulated in lichen 0.29 35.48320 334 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_005338-T1 pTM below threshold NA Non-DGE 0.3 42.89314 299 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_005364-T1 pTM below threshold NA Upregulated in lichen 0.35 59.45167 102 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_005536-T1 pTM below threshold NA Non-DGE 0.11 43.11011 180 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_005573-T1 pTM below threshold NA Upregulated in lichen 0.27 41.92369 244 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_005653-T1 pTM below threshold NA Non-DGE 0.27 35.34574 289 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_005717-T1 pTM below threshold NA Upregulated in lichen 0.35 35.15150 213 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_005718-T1 pTM below threshold NA Non-DGE 0.2 33.49452 292 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_005733-T1 pTM below threshold NA Upregulated in lichen 0.2 28.61554 350 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_005759-T1 pTM below threshold NA Upregulated in culture 0.37 60.31197 218 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_005792-T1 pTM below threshold NA Non-DGE 0.32 75.71431 534 IPR018392 LysM domain;IPR036779 LysM domain superfamily CBM50 NA Antimicrobial 4B9H; Cladosporium fulvum LysM effector Ecp6 in complex with a beta-1,4- linked N-acetyl-D-glucosamine tetramer: I3C heavy atom derivative; 7.082e-05 NA A0A0C2IKZ1; LysM domain-containing protein; Sporothrix brasiliensis 5110; 1.409e-38 U7PMK7; LysM domain-containing protein; Sporothrix schenckii (strain ATCC 58251 / de Perez 2211183) (Rose-picker’s disease fungus); 8.377e-38
XANPAGTX0501_005813-T1 pTM below threshold NA Non-DGE 0.43 62.54160 288 IPR018466 Yeast cell wall synthesis Kre9/Knh1-like, N-terminal NA NA Below pLDDT threshold NA NA A0A443I375; GPI anchored serine-threonine rich protein; Byssochlamys spectabilis (Paecilomyces variotii); 1.373e-13 A0A2T2NIQ0; Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein; Corynespora cassiicola Philippines; 8.064e-13
XANPAGTX0501_005845-T1 pTM below threshold NA Non-DGE 0.3 55.95631 931 IPR002889 Carbohydrate-binding WSC AA2, AA5 NA Below pLDDT threshold 5I25; human recombinant coagulation FXI in complex with a peptide derived from human high molecular weight kininogen (HKP); 5.622e-10 5EOK; Human Plasma Coagulation Factor XI in complex with peptide P39; 7.873e-10 A0A6A6YV25; Apple domain-containing protein; Mytilinidion resinicola; 1.527e-20 A0A0D2CZ88; Apple domain-containing protein; Exophiala xenobiotica; 7.741e-18
XANPAGTX0501_005926-T1 pTM below threshold NA Non-DGE 0.31 36.87731 212 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_006010-T1 pTM below threshold NA Non-DGE 0.26 41.65388 224 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_006091-T1 pTM below threshold NA Upregulated in culture 0.37 59.93578 296 NA NA NA Below pLDDT threshold NA NA A0A0D2G7D5; Extracellular membrane protein CFEM domain-containing protein; Fonsecaea pedrosoi CBS 271.37; 6.802e-05 A0A0D2CC38; Extracellular membrane protein CFEM domain-containing protein; Cladophialophora immunda; 0.0001483
XANPAGTX0501_006135-T1 pTM below threshold NA Non-DGE 0.21 44.10064 344 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_006144-T1 pTM below threshold NA Non-DGE 0.29 29.79741 355 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_006188-T1 pTM below threshold NA Non-DGE 0.4 45.56256 641 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_006200-T1 pTM below threshold NA Non-DGE 0.22 38.86053 375 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_006216-T1 pTM below threshold NA Non-DGE 0.45 74.14030 164 NA NA NA Antimicrobial NA NA A0A6A6RAX6; EGF-like domain-containing protein; Lophium mytilinum; 9.832e-07 NA
XANPAGTX0501_006245-T1 pTM below threshold NA Upregulated in lichen 0.38 40.98643 224 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_006269-T1 pTM below threshold NA Non-DGE 0.35 36.31963 217 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_006277-T1 pTM below threshold NA Non-DGE 0.22 34.49871 202 IPR004212 GTF2I-like repeat NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_006282-T1 pTM below threshold NA Upregulated in lichen 0.29 37.07552 212 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_006327-T1 pTM below threshold NA Upregulated in lichen 0.39 52.12547 311 IPR018466 Yeast cell wall synthesis Kre9/Knh1-like, N-terminal NA NA Below pLDDT threshold NA NA A0A0D1ZSJ7; Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein; Exophiala mesophila (Black yeast); 5.571e-07 A0A0F8V2U6; Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein; Aspergillus ochraceoroseus; 3.566e-06
XANPAGTX0501_006345-T1 pTM below threshold NA Non-DGE 0.26 41.90220 141 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_006386-T1 pTM below threshold NA Upregulated in culture 0.39 47.84989 445 NA NA NA Below pLDDT threshold NA NA A0A1B9G3W8; Uncharacterized protein; Kwoniella bestiolae CBS 10118; 1.331e-07 A0A1A6AB64; Uncharacterized protein; Kwoniella dejecticola CBS 10117; 1.91e-07
XANPAGTX0501_006396-T1 pTM below threshold NA Non-DGE 0.28 38.38777 247 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_006430-T1 pTM below threshold NA Non-DGE 0.4 58.62042 526 NA NA NA Below pLDDT threshold NA NA C9SCF8; Predicted protein; Verticillium alfalfae (strain VaMs.102 / ATCC MYA-4576 / FGSC 10136) (Verticillium wilt of alfalfa) (Verticillium albo-atrum); 3.233e-15 A0A507BM56; Uncharacterized protein; Thyridium curvatum; 6.992e-15
XANPAGTX0501_006469-T1 pTM below threshold NA Non-DGE 0.43 42.74056 214 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_006612-T1 pTM below threshold NA Non-DGE 0.33 41.95192 291 IPR036779 LysM domain superfamily NA NA Below pLDDT threshold NA NA A0A0J8RMW3; LysM domain-containing protein; Coccidioides immitis H538.4; 5.611e-08 E9DDV5; LysM domain-containing protein; Coccidioides posadasii (strain RMSCC 757 / Silveira) (Valley fever fungus); 1.291e-07
XANPAGTX0501_006642-T1 pTM below threshold NA Non-DGE 0.23 50.69881 210 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_006751-T1 pTM below threshold NA Upregulated in lichen 0.25 29.51219 237 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_006771-T1 pTM below threshold NA Non-DGE 0.25 45.20033 122 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_006846-T1 pTM below threshold NA Upregulated in lichen 0.39 60.82377 106 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_006848-T1 pTM below threshold NA Upregulated in culture 0.18 56.75794 107 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_006860-T1 pTM below threshold NA Upregulated in lichen 0.49 60.95872 321 IPR008979 Galactose-binding-like domain superfamily NA NA Below pLDDT threshold 5W6H; Crystal structure of Bacteriophage CBA120 tailspike protein 4 enzymatically active domain (TSP4dN, orf213); 2.258e-06 5X7S; Crystal structure of Paenibacillus sp. 598K alpha-1,6-glucosyltransferase, terbium derivative; 2.023e-05 A0A6A6YIM7; CBM-cenC domain-containing protein; Mytilinidion resinicola; 8.037e-07 A0A5E4KIN1; Uncharacterized protein; Uncultured archaeon; 3.342e-06
XANPAGTX0501_006870-T1 pTM below threshold NA Non-DGE 0.25 49.69147 347 IPR018909 Endo-1,3(4)-beta-glucanase 1, carbohydrate binding CBM52 NA Below pLDDT threshold NA NA R7YMC8; Endo-1,3(4)-beta-glucanase 1 carbohydrate binding domain-containing protein; Coniosporium apollinis (strain CBS 100218) (Rock-inhabiting black yeast); 1.193e-05 A0A1S9RPI8; Endo-1,3(4)-beta-glucanase 1 carbohydrate binding domain-containing protein; Penicillium brasilianum; 2.619e-05
XANPAGTX0501_006878-T1 pTM below threshold NA Non-DGE 0.48 55.66750 184 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_006927-T1 pTM below threshold NA Non-DGE 0.29 39.10967 182 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_007125-T1 pTM below threshold NA Non-DGE 0.31 37.96095 315 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_007184-T1 pTM below threshold NA Non-DGE 0.27 35.92510 204 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_007194-T1 pTM below threshold NA Non-DGE 0.4 52.33116 147 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_007362-T1 pTM below threshold NA Upregulated in lichen 0.27 33.91120 392 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_007451-T1 pTM below threshold NA Non-DGE 0.35 45.09716 155 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_007556-T1 pTM below threshold NA Non-DGE 0.32 42.12523 128 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_007596-T1 pTM below threshold NA Non-DGE 0.32 52.98769 471 NA NA NA Below pLDDT threshold NA NA A0A0D8JU73; GPI anchored protein; Coccidioides immitis (strain RS) (Valley fever fungus); 1.668e-13 A0A117NP65; Uncharacterized protein; Penicillium freii; 9.925e-13
XANPAGTX0501_007662-T1 pTM below threshold NA Non-DGE 0.41 67.45495 303 IPR036908 RlpA-like domain superfamily NA NA Non-antimicrobial 5NTB; Streptomyces papain inhibitor (SPI); 6.385e-12 4L48; Crystal structure of d78n mutant clavibacter michiganensis expansin in complex with cellohexaose; 3.418e-06 A0A094D7Z3; RlpA-like protein double-psi beta-barrel domain-containing protein; Pseudogymnoascus sp. VKM F-4515 (FW-2607); 1.021e-16 K1XV49; Riboflavin aldehyde-forming enzyme; Marssonina brunnea f. sp. multigermtubi (strain MB_m1) (Marssonina leaf spot fungus); 5.927e-16
XANPAGTX0501_007855-T1 pTM below threshold NA Non-DGE 0.44 55.95904 114 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_007865-T1 pTM below threshold NA Upregulated in lichen 0.2 34.63703 209 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_007939-T1 pTM below threshold NA Upregulated in lichen 0.39 38.59798 258 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_007940-T1 pTM below threshold NA Non-DGE 0.35 41.71245 220 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_008019-T1 pTM below threshold NA Upregulated in lichen 0.43 46.04617 227 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_008041-T1 pTM below threshold NA Upregulated in lichen 0.27 33.06829 287 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_008135-T1 pTM below threshold NA Non-DGE 0.29 48.80956 228 NA NA NA Below pLDDT threshold NA NA A0A167V6T8; Uncharacterized protein; Ascosphaera apis ARSEF 7405; 0.0008161 NA
XANPAGTX0501_008148-T1 pTM below threshold NA Non-DGE 0.25 36.09338 717 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_008162-T1 pTM below threshold NA Non-DGE 0.2 35.30811 286 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_008182-T1 pTM below threshold NA Non-DGE 0.35 47.60920 125 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_008186-T1 pTM below threshold NA Non-DGE 0.46 58.11869 374 IPR008972 Cupredoxin NA NA Below pLDDT threshold 3CVD; Regulation of Protein Function: Crystal Packing Interfaces and Conformational Dimerization; 9.21e-06 2W88; Plastocyanin variant with N-terminal Methionine - open structure; 9.776e-06 C4JT37; Phytocyanin domain-containing protein; Uncinocarpus reesii (strain UAMH 1704); 2.287e-22 A0A0C3HWR8; Phytocyanin domain-containing protein; Oidiodendron maius (strain Zn); 3.911e-22
XANPAGTX0501_008218-T1 pTM below threshold NA Non-DGE 0.46 46.12536 418 IPR024079 Metallopeptidase, catalytic domain superfamily NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_008219-T1 pTM below threshold NA Non-DGE 0.49 59.06300 290 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_008281-T1 pTM below threshold NA Non-DGE 0.32 44.73137 161 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_008351-T1 pTM below threshold NA Non-DGE 0.47 73.50206 559 NA NA NA Antimicrobial NA NA A0A094A2F5; Uncharacterized protein; Pseudogymnoascus sp. VKM F-4281 (FW-2241); 3.078e-37 A0A284RFH5; Related to cell wall mannoprotein; Armillaria ostoyae (Armillaria root rot fungus); 3.704e-33
XANPAGTX0501_008400-T1 pTM below threshold NA Non-DGE 0.44 63.87267 262 IPR018466 Yeast cell wall synthesis Kre9/Knh1-like, N-terminal NA NA Below pLDDT threshold NA NA A0A6G1HP33; Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein; Trichodelitschia bisporula; 5.099e-11 A0A6C1LWC6; deleted; ; 5.704e-11
XANPAGTX0501_008424-T1 pTM below threshold NA Non-DGE 0.47 67.70070 229 IPR018466 Yeast cell wall synthesis Kre9/Knh1-like, N-terminal NA NA Non-antimicrobial 7XT6; Structure of a membrane protein M3; 0.0008373 NA R7YRL3; Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein; Coniosporium apollinis (strain CBS 100218) (Rock-inhabiting black yeast); 8.236e-12 A0A6G1H9J1; Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein; Aulographum hederae CBS 113979; 8.236e-12
XANPAGTX0501_008443-T1 pTM below threshold NA Non-DGE 0.42 65.45769 744 IPR002889 Carbohydrate-binding WSC AA2, AA5 NA Antimicrobial 5FWW; Wnt modulator Kremen in complex with DKK1 (CRD2) and LRP6 (PE3PE4); 3.046e-06 7PZ2; Structure of the mechanosensor domain of Wsc1 from Saccharomyces cerevisiae; 0.0001756 A0A1Q8RZZ8; WSC domain-containing protein-like protein 4; Colletotrichum chlorophyti; 2.882e-49 G0RCZ5; N-terminal WSC domain-containing protein; Hypocrea jecorina (strain QM6a) (Trichoderma reesei); 2.272e-38
XANPAGTX0501_008477-T1 pTM below threshold NA Non-DGE 0.34 38.65885 183 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_008519-T1 pTM below threshold NA Non-DGE 0.42 50.80404 1065 NA NA NA Below pLDDT threshold NA NA A0A139H0H7; Chitin-binding type-1 domain-containing protein; Pseudocercospora eumusae; 2.429e-16 M3AJY5; Apple domain-containing protein; Pseudocercospora fijiensis (strain CIRAD86) (Black leaf streak disease fungus) (Mycosphaerella fijiensis); 5.071e-15
XANPAGTX0501_008553-T1 pTM below threshold NA Non-DGE 0.21 35.48684 779 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_008622-T1 pTM below threshold NA Upregulated in lichen 0.27 36.45940 184 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_008694-T1 pTM below threshold NA Non-DGE 0.22 40.74125 265 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_008809-T1 pTM below threshold NA Non-DGE 0.31 45.66059 488 NA NA NA Below pLDDT threshold NA NA A0A4S8SXU7; feruloyl esterase (EC 3.1.1.73); Aureobasidium pullulans (Black yeast) (Pullularia pullulans); 2.438e-06 A0A4S9HI98; feruloyl esterase (EC 3.1.1.73); Aureobasidium pullulans (Black yeast) (Pullularia pullulans); 3.099e-06
XANPAGTX0501_008872-T1 pTM below threshold NA Non-DGE 0.35 34.38388 201 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_008875-T1 pTM below threshold NA Upregulated in lichen 0.25 36.22508 128 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_008931-T1 pTM below threshold NA Non-DGE 0.19 44.85339 221 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_008948-T1 pTM below threshold NA Non-DGE 0.17 38.85130 231 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_008971-T1 pTM below threshold NA Non-DGE 0.41 44.89566 316 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_008978-T1 pTM below threshold NA Upregulated in lichen 0.27 39.13834 193 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_008987-T1 pTM below threshold NA Non-DGE 0.28 39.11374 171 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_009011-T1 pTM below threshold NA Upregulated in lichen 0.2 56.92495 99 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_009191-T1 pTM below threshold NA Non-DGE 0.48 59.44738 122 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_009292-T1 pTM below threshold NA Non-DGE 0.49 45.18802 333 NA NA NA Below pLDDT threshold NA NA A0A4Q4R4H3; deleted; ; 2.317e-07 A0A7U2F0M6; Uncharacterized protein; Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Parastagonospora nodorum); 2.943e-06
XANPAGTX0501_009295-T1 pTM below threshold NA Non-DGE 0.47 52.70230 721 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_009312-T1 pTM below threshold NA Non-DGE 0.45 48.78964 966 IPR000757 Glycoside hydrolase family 16;IPR013320 Concanavalin A-like lectin/glucanase domain superfamily GH16 NA Below pLDDT threshold 6IBW; Crh5 transglycosylase in complex with NAG; 7.599e-33 6IBU; Apo Crh5 transglycosylase; 1.787e-32 A0A0S6XEC7; GH16 domain-containing protein; Fungal sp. (strain No.11243); 1.298e-33 A0A4V3UP95; Glycosidase (EC 3.2.-.-); Aspergillus tanneri; 7.181e-33
XANPAGTX0501_009324-T1 pTM below threshold NA Non-DGE 0.18 55.03943 87 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_009430-T1 pTM below threshold NA Non-DGE 0.29 51.23665 251 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_009502-T1 pTM below threshold NA Non-DGE 0.14 51.21467 150 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_009607-T1 pTM below threshold NA Upregulated in lichen 0.32 33.84773 309 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_009615-T1 pTM below threshold NA Upregulated in lichen 0.32 65.99257 113 IPR035940 CAP superfamily NA NA Non-antimicrobial NA NA NA NA
XANPAGTX0501_009668-T1 pTM below threshold NA Upregulated in lichen 0.24 62.61028 212 NA NA NA Below pLDDT threshold NA NA H6C1Q2; Uncharacterized protein; Exophiala dermatitidis (strain ATCC 34100 / CBS 525.76 / NIH/UT8656) (Black yeast) (Wangiella dermatitidis); 3.367e-07 A0A366S4S1; Uncharacterized protein; Fusarium coffeatum; 2.219e-06
XANPAGTX0501_009682-T1 pTM below threshold NA Non-DGE 0.39 39.61619 236 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_009683-T1 pTM below threshold NA Upregulated in lichen 0.24 30.44388 428 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_009688-T1 pTM below threshold NA Upregulated in lichen 0.24 49.57690 290 IPR000254 Cellulose-binding domain, fungal;IPR035971 Cellulose-binding domain superfamily;IPR036908 RlpA-like domain superfamily NA NA Below pLDDT threshold 4QI4; Dehydrogenase domain of Myriococcum thermophilum cellobiose dehydrogenase, MtDH; 0.0006969 NA N4X993; Endo-beta-1,4-glucanase D (Endoglucanase D) (EC 3.2.1.4) (Carboxymethylcellulase D) (Cellulase D); Cochliobolus heterostrophus (strain C4 / ATCC 48331 / race T) (Southern corn leaf blight fungus) (Bipolaris maydis); 0.0007107 NA
XANPAGTX0501_009689-T1 pTM below threshold NA Upregulated in lichen 0.31 41.64505 222 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_009692-T1 pTM below threshold NA Non-DGE 0.3 42.07158 215 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_009726-T1 pTM below threshold NA Non-DGE 0.23 48.70371 124 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_009730-T1 pTM below threshold NA Upregulated in lichen 0.28 47.45514 255 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_009793-T1 pTM below threshold NA Non-DGE 0.21 35.83401 207 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_009844-T1 pTM below threshold NA Non-DGE 0.38 37.60851 241 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_009857-T1 pTM below threshold NA Non-DGE 0.49 52.14888 179 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_009886-T1 pTM below threshold NA Upregulated in lichen 0.2 40.27393 112 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_009899-T1 pTM below threshold NA Non-DGE 0.19 35.46123 203 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_009901-T1 pTM below threshold NA Non-DGE 0.23 32.99650 180 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_009962-T1 pTM below threshold NA Upregulated in culture 0.45 57.73133 294 NA NA NA Below pLDDT threshold NA NA A0A2T4A4W1; Apple domain-containing protein; Trichoderma harzianum CBS 226.95; 0.0007207 NA
XANPAGTX0501_010021-T1 pTM below threshold NA Upregulated in lichen 0.15 39.63054 224 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_010022-T1 pTM below threshold NA Upregulated in lichen 0.2 40.20379 116 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_010026-T1 pTM below threshold NA Upregulated in lichen 0.36 50.82466 371 IPR018392 LysM domain;IPR036779 LysM domain superfamily NA NA Below pLDDT threshold NA NA A0A6G1ML62; Uncharacterized protein; Orbilia oligospora (Nematode-trapping fungus) (Arthrobotrys oligospora); 4.647e-09 A0A7C8K1K9; LysM domain-containing protein; Orbilia oligospora (Nematode-trapping fungus) (Arthrobotrys oligospora); 1.75e-08
XANPAGTX0501_010040-T1 pTM below threshold NA Upregulated in lichen 0.42 52.91466 290 NA NA NA Below pLDDT threshold NA NA A0A1B8AR82; Uncharacterized protein; Fusarium poae; 5.417e-07 A0A136ISV8; Uncharacterized protein; Microdochium bolleyi; 1.31e-06
XANPAGTX0501_010086-T1 pTM below threshold NA Non-DGE 0.17 55.87331 151 IPR000420 Yeast PIR protein repeat NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_010088-T1 pTM below threshold NA Non-DGE 0.45 59.31449 312 NA NA NA Below pLDDT threshold NA NA Q2HDI8; Uncharacterized protein; Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus); 1.063e-13 A0A0D1XIR7; Uncharacterized protein; Verruconis gallopava; 2.728e-13
XANPAGTX0501_010096-T1 pTM below threshold NA Non-DGE 0.25 41.67990 292 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_010127-T1 pTM below threshold NA Non-DGE 0.43 67.28046 87 NA NA NA Non-antimicrobial NA NA NA NA
XANPAGTX0501_010138-T1 pTM below threshold NA Non-DGE 0.11 41.18544 204 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_010307-T1 pTM below threshold NA Upregulated in culture 0.26 29.37579 356 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_010329-T1 pTM below threshold NA Non-DGE 0.23 55.70355 107 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_010382-T1 pTM below threshold NA Non-DGE 0.3 37.89519 833 NA NA NA Below pLDDT threshold NA NA A0A066X6J5; Putative alpha-1,3-glucanase; Colletotrichum sublineola (Sorghum anthracnose fungus); 5.117e-11 A0A4S9I1D4; Uncharacterized protein; Aureobasidium pullulans (Black yeast) (Pullularia pullulans); 1.349e-10
XANPAGTX0501_010393-T1 pTM below threshold NA Upregulated in culture 0.36 68.70766 209 NA NA NA Non-antimicrobial NA NA NA NA
XANPAGTX0501_010394-T1 pTM below threshold NA Non-DGE 0.29 42.73618 173 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_010595-T1 pTM below threshold NA Non-DGE 0.25 31.68788 170 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_010636-T1 pTM below threshold NA Non-DGE 0.2 30.96896 279 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_010737-T1 pTM below threshold NA Non-DGE 0.49 47.04299 354 NA NA NA Below pLDDT threshold NA NA NA NA
XANPAGTX0501_010738-T1 pTM below threshold NA Non-DGE 0.48 50.86233 356 NA NA NA Below pLDDT threshold NA NA NA NA

6. Visualize

library(RColorBrewer)

#define palette
get_11_colors<-function(color){ # a function for each color gives 11 shades from dark to light as a dataframe with one row
  colfunc1 <- colorRampPalette(c("black", color))
  colfunc2 <- colorRampPalette(c(color,"white"))
  darks<-colfunc1(10)[7:10]
  lights<-colfunc2(10)[2:8]
  return(c(darks,lights))
}
l<-lapply(brewer.pal(8,"Dark2"),get_11_colors)
color_table<-do.call(rbind,l)
color_table<-data.frame(color_table)
color_table$hue<-brewer.pal(8,"Dark2")
color_list<-color_table %>% pivot_longer(-hue,names_to="shade",values_to = "color") %>%
  mutate(shade2 = case_when(shade=="X10"~"XX10",shade=="X11"~"XX11",T~shade)) %>% arrange(shade2) %>% select(color)

#add pallet to the cluster list
cluster_info_col<-cbind(cluster_info,color_list[1:84,])

#get common ancestors for all clades
itol_tree<-makeNodeLabel(lddt)
write.tree(itol_tree,"../analysis_and_temp_files/05_cluster_structures/lddt_tree_itol.nwk")
get_clade_node<-function(cluster,tree="itol_tree"){
  tips<-clusters_df$tip[clusters_df$cluster_id==cluster]
  mrsa_node<-findMRCA(itol_tree,tips,type="node")
  node<-itol_tree$node.label[mrsa_node - length(itol_tree$tip.label)]
  return(node)
}

cluster_info_col$node<-sapply(cluster_info_col$cluster_id,get_clade_node) 
#had to manually assign the node for cl42 (the one that has 1 protein only)
cluster_info_col$node[cluster_info_col$cluster_id=="cl42"]<-clusters_df$tip[clusters_df$cluster_id=="cl42"]
cluster_info_col$node<-unlist(cluster_info_col$node)
write.table(cluster_info_col,"../analysis_and_temp_files/05_cluster_structures/cluster_col.txt",sep=",",quote = F, row.names = F, col.names=T)

#prepare the dataset
cat("DATASET_RANGE\nSEPARATOR COMMA\nDATASET_LABEL,Cluster\nRANGE_COVER,clade\nDATA\n", file="../analysis_and_temp_files/05_cluster_structures/itol_clusters.txt")

itol_data<-cluster_info_col %>% mutate(node2=node) %>%
  select(node,node2,color) 

write.table(itol_data,"../analysis_and_temp_files/05_cluster_structures/itol_clusters.txt",append=TRUE,sep=",",quote = F, row.names = F, col.names=F)
knitr::include_graphics("../results/cluster_tree/clusters.png")

dge <- ann %>% mutate(ProteinID=str_replace(TranscriptID,"XANPAGTX0501","FUN")) %>% filter(ProteinID %in% lddt$tip.label) %>% 
  mutate(symbol1 = case_when(DGE=="Upregulated in lichen" ~ 1, T ~ -1),
         symbol2 = case_when(DGE=="Upregulated in culture" ~ 1,T ~ -1)) %>%
  select(ProteinID,symbol1,symbol2)

#prepare the dataset
cat("DATASET_BINARY\nSEPARATOR COMMA\nDATASET_LABEL,Differentially Expressed\nCOLOR,#ff0000\nFIELD_LABELS,Upregulated in lichen,Upregulated in culture\nFIELD_SHAPES,4,5\nFIELD_COLORS,#F8766D,#00B6EB\nDATA\n", file="../analysis_and_temp_files/05_cluster_structures/itol_dge.txt")

write.table(dge,"../analysis_and_temp_files/05_cluster_structures/itol_dge.txt",append=TRUE,sep=",",quote = F, row.names = F, col.names=F)
knitr::include_graphics("../results/cluster_tree/clusters_dge.png")

cazy_cluster_list<-combined %>%
  mutate(cazy_binary=ifelse(is.na(CAZyme_new),"noncazy","cazy")) %>%
  group_by(ClusterID,cazy_binary) %>% summarize(n=n()) %>%
  pivot_wider(names_from = cazy_binary,values_from = n,values_fill=0)  %>%
  mutate(cazy_perc=cazy/(cazy+noncazy)) %>% filter(cazy_perc>0.5) 
## `summarise()` has grouped output by 'ClusterID'. You can override using the
## `.groups` argument.
cluster_info_col_cazy <- cluster_info_col %>% 
  filter(cluster_id %in% cazy_cluster_list$ClusterID) %>%
  mutate(node2=node) %>% select(node,node2,color) 

#add 'range' for CAZymes not in the clusters above
ind_cazy_list<-combined %>% filter(!is.na(CAZyme_new),
                                   !(ClusterID %in% cazy_cluster_list$ClusterID),
                                   ClusterID!="pTM below threshold") %>%
  mutate(node=str_replace(ProteinID,"XANPAGTX0501","FUN"),node2=str_replace(ProteinID,"XANPAGTX0501","FUN")) %>% select(node,node2)
#define colors as shades of light grey
colfunc <- colorRampPalette(c("#d4d4d4", "#a8a8a8"))
ind_cazy_list$color<-colfunc(nrow(ind_cazy_list))

#prepare the dataset
cat("DATASET_RANGE\nSEPARATOR COMMA\nDATASET_LABEL,CAZymes\nRANGE_COVER,clade\nDATA\n", file="../analysis_and_temp_files/05_cluster_structures/itol_cazy.txt")

write.table(rbind(cluster_info_col_cazy,ind_cazy_list),"../analysis_and_temp_files/05_cluster_structures/itol_cazy.txt",append=TRUE,sep=",",quote = F, row.names = F, col.names=F)
knitr::include_graphics("../results/cluster_tree/cazy_dge.png")

protease_cluster_list<-combined %>%
  mutate(protease_binary=ifelse(is.na(Protease_new),"nonprotease","protease")) %>%
  group_by(ClusterID,protease_binary) %>% summarize(n=n()) %>%
  pivot_wider(names_from = protease_binary,values_from = n,values_fill=0)  %>%
  mutate(protease_perc=protease/(protease+nonprotease)) %>% filter(protease_perc>0.5) 
## `summarise()` has grouped output by 'ClusterID'. You can override using the
## `.groups` argument.
cluster_info_col_protease <- cluster_info_col %>% 
  filter(cluster_id %in% c(protease_cluster_list$ClusterID,"cl32","cl83")) %>%
  mutate(node2=node) %>% select(node,node2,color) 

#add 'range' for proteases not in the clusters above
ind_protease_list<-combined %>% filter(!(ClusterID %in% c(protease_cluster_list$ClusterID,"cl32","cl83")),ClusterID!="pTM below threshold") %>%
  filter(!is.na(Protease_new) | grepl("eptidase",InterPro) |
           grepl("rotease",InterPro)) %>%
  mutate(node=str_replace(ProteinID,"XANPAGTX0501","FUN"),node2=str_replace(ProteinID,"XANPAGTX0501","FUN")) %>% select(node,node2)
#define colors as shades of light grey
colfunc <- colorRampPalette(c("#d4d4d4", "#a8a8a8"))
ind_protease_list$color<-colfunc(nrow(ind_protease_list))

#prepare the dataset
cat("DATASET_RANGE\nSEPARATOR COMMA\nDATASET_LABEL,Protease\nRANGE_COVER,clade\nDATA\n", file="../analysis_and_temp_files/05_cluster_structures/itol_protease.txt")

write.table(rbind(cluster_info_col_protease,ind_protease_list),"../analysis_and_temp_files/05_cluster_structures/itol_protease.txt",append=TRUE,sep=",",quote = F, row.names = F, col.names=F)
knitr::include_graphics("../results/cluster_tree/protease_dge.png")

int_cluster_list <- c("cl04","cl16","cl18","cl19","cl20","cl21","cl22","cl23",
                      "cl24","cl24a","cl37","cl38","cl40","cl41","cl42","cl80",
                      "cl29","cl34")
  
cluster_info_col_int <- cluster_info_col %>% 
  filter(cluster_id %in% int_cluster_list) %>%
  mutate(node2=node) %>% select(node,node2,color) 

#prepare the dataset
cat("DATASET_RANGE\nSEPARATOR COMMA\nDATASET_LABEL,Putative Effectors\nRANGE_COVER,clade\nDATA\n", file="../analysis_and_temp_files/05_cluster_structures/itol_interest.txt")

write.table(rbind(cluster_info_col_int),"../analysis_and_temp_files/05_cluster_structures/itol_interest.txt",append=TRUE,sep=",",quote = F, row.names = F, col.names=F)
knitr::include_graphics("../results/cluster_tree/interest_dge.png")

effp<-read.delim2("../analysis_and_temp_files/01_predicting_effectors/effectorp_GTX0501.out")
effp$prot<-gsub( " .*$", "", effp$X..Identifier)
effp$prot<-str_replace(effp$prot,"FUN","XANPAGTX0501")
deep1<-read.csv2("../analysis_and_temp_files/01_predicting_effectors/deepredeef_prediction_1.csv",sep=",")
deep2<-read.csv2("../analysis_and_temp_files/01_predicting_effectors/deepredeef_prediction_2.csv",sep=",")
deep<-rbind(deep1,deep2)
deep$prot<-gsub( " .*$", "", deep$name)
deep$prot<-str_replace(deep$prot,"FUN","XANPAGTX0501")

effp %>% filter(prot %in% clusters_df$TranscriptID[clusters_df$cluster_id=="cl04"]) %>% select(prot,Prediction,Non.effector)
##                     prot   Prediction Non.effector
## 1 XANPAGTX0501_000516-T1 Non-effector     Y (0.79)
## 2 XANPAGTX0501_002012-T1 Non-effector    Y (0.921)
## 3 XANPAGTX0501_002315-T2 Non-effector     Y (0.96)
## 4 XANPAGTX0501_003678-T1 Non-effector    Y (0.736)
## 5 XANPAGTX0501_005039-T1 Non-effector    Y (0.853)
## 6 XANPAGTX0501_005768-T1 Non-effector    Y (0.819)
## 7 XANPAGTX0501_009148-T1 Non-effector    Y (0.962)
## 8 XANPAGTX0501_010247-T1 Non-effector    Y (0.933)
deep %>% filter(prot %in% clusters_df$TranscriptID[clusters_df$cluster_id=="cl04"]) %>% select(prot,prediction,s_score)
##                         prot   prediction            s_score
## 533   XANPAGTX0501_000516-T1     effector  0.970979988574982
## 2088  XANPAGTX0501_002012-T1 non-effector  0.341907918453217
## 2401  XANPAGTX0501_002315-T2     effector  0.587720155715942
## 3831  XANPAGTX0501_003678-T1     effector  0.964024305343628
## 25210 XANPAGTX0501_005039-T1     effector  0.841638267040253
## 9971  XANPAGTX0501_005768-T1     effector  0.958712518215179
## 44871 XANPAGTX0501_009148-T1 non-effector  0.424879431724548
## 5617  XANPAGTX0501_010247-T1 non-effector 0.0446633771061897
hyd_cluster_list<-c(protease_cluster_list$ClusterID,cazy_cluster_list$ClusterID,
                    "cl05","cl07","cl11","cl12","cl58","cl32","cl83") 

cluster_info_col_hyd <- cluster_info_col %>% 
  filter(cluster_id %in% hyd_cluster_list) %>%
  mutate(node2=node) %>% select(node,node2,color) 

#prepare the dataset
cat("DATASET_RANGE\nSEPARATOR COMMA\nDATASET_LABEL,Hydrolase\nRANGE_COVER,clade\nDATA\n", file="../analysis_and_temp_files/05_cluster_structures/itol_hydrolase.txt")

write.table(cluster_info_col_hyd,"../analysis_and_temp_files/05_cluster_structures/itol_hydrolase.txt",append=TRUE,sep=",",quote = F, row.names = F, col.names=F)
hyd_cluster_list<-c(protease_cluster_list$ClusterID,cazy_cluster_list$ClusterID,
                    "cl05","cl07","cl11","cl12","cl58","cl32","cl83") 

cluster_info_col_hyd <- cluster_info_col %>% 
  filter(cluster_id %in% hyd_cluster_list) %>%
  mutate(node2=node) %>% select(node,node2,color) 

#prepare the dataset
cat("DATASET_RANGE\nSEPARATOR COMMA\nDATASET_LABEL,Hydrolase\nRANGE_COVER,clade\nDATA\n", file="../analysis_and_temp_files/05_cluster_structures/itol_hydrolase.txt")

write.table(cluster_info_col_hyd,"../analysis_and_temp_files/05_cluster_structures/itol_hydrolase.txt",append=TRUE,sep=",",quote = F, row.names = F, col.names=F)